Top Supporting Studies To Our Work

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➡️ Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA  https://www.nature.com/articles/s41598-017-08392-1

➡️ Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2  https://pmc.ncbi.nlm.nih.gov/articles/PMC6182158/

➡️ Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review
https://pubmed.ncbi.nlm.nih.gov/35211738/

➡️ Fluoroquinolone antibiotics show genotoxic effect through DNA-binding and oxidative damage. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
https://pubmed.ncbi.nlm.nih.gov/31756649/

 ➥   For additional studies, please see our large library compilation of scientific studies, in addition to what is on this page:

Chemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity
https://chemrxiv.org/engage/chemrxiv/article-details/67165e8712ff75c3a1142bb7

Multifocal dystonia induced by levofloxacin
https://doi.org/10.31024/ajpp.2018.4.1.16

The effects of ciprofloxacin on male rabbits: Biochemical and histopathological study
https://uobasrah.edu.iq/research/sciresearch/10123

Chromosomal aberrations in human lymphocytes exposed in vitro to enrofloxacin and ciprofloxacin
https://pubmed.ncbi.nlm.nih.gov/10048748/

Cytotoxic and genotoxic effects induced by enrofloxacin-based antibiotic formulation Floxagen® in two experimental models of bovine cells in vitro: peripheral lymphocytes and cumulus cells
https://pubmed.ncbi.nlm.nih.gov/30506381/

Fluoroquinolones are a potent form of chemotherapy
https://pubmed.ncbi.nlm.nih.gov/32484262/

Adverse drug reactions related to the use of fluoroquinolone antimicrobials: An analysis of spontaneous reports and fluoroquinolone consumption data from three Italian regions
https://link.springer.com/article/10.2165/00002018-200326020-00004

Fluoroquinolone-induced serious, persistent, multisymptom adverse effects
https://pmc.ncbi.nlm.nih.gov/articles/PMC4600819/

4-Quinolone drugs affect cell cycle progression and function of human lymphocytes in vitro
https://pmc.ncbi.nlm.nih.gov/articles/PMC174830/

A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods
https://pubmed.ncbi.nlm.nih.gov/20049419/

Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity: Studies with gemifloxacin, moxifloxacin and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages
https://pubmed.ncbi.nlm.nih.gov/21764262/

Nonantibiotic effects of fluoroquinolones in mammalian cells
https://pmc.ncbi.nlm.nih.gov/articles/PMC4571980/

Pharmacokinetic prediction of levofloxacin accumulation in tissue and its association to tendinopathy
https://www.scirp.org/journal/paperinformation?paperid=27531

Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells
https://pmc.ncbi.nlm.nih.gov/articles/PMC3760005/

Delayed cytotoxicity and cleavage of mitochondrial DNA in ciprofloxacin-treated mammalian cells
https://pubmed.ncbi.nlm.nih.gov/8913349/

Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective
https://www.sciencedirect.com/science/article/pii/S0300483X08004204

High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells
https://pubmed.ncbi.nlm.nih.gov/20625181/

Role of mitochondria in ciprofloxacin-induced apoptosis in murine sperm cells
https://pubmed.ncbi.nlm.nih.gov/23420823/

Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro
https://pubmed.ncbi.nlm.nih.gov/20334059/

Exploration of the neurotoxicity of ciprofloxacin or gatifloxacin single dose in rat cortex and hippocampus
https://academicjournals.org/journal/AJPP/article-full-text/4BCF40A50432

Risk of hepatotoxicity associated with fluoroquinolones: A national case-control safety study
https://pubmed.ncbi.nlm.nih.gov/24352180/

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