Top Supporting Studies To Our Work
1. Németh et al. Aug 15, 2017. Scientific Reports. Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. https://www.nature.com/articles/s41598-017-08392-1.pdf
Németh, Orgovan, Sódar, Osteikoetxea, Pálóczi, Szabó-Taylor, Vukman, Kittel, Turiák, Wiener, Tóth, Drahos, Vékey, Horvath & Buzás
2. Hangas et al. Oct 12, 2018. Nucleic Acids Research, Volume 46, Issue 18.
Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182158/
Hangas, Aasumets, Kekäläinen, Paloheinä, Pohjoismäki, Gerhold & Goffar
3. Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review
All scientific publications since the 1980’s related to the following Fluoroquinolone side effects have been largely ignored by the authorities: DNA damage; mitochondrial damage; accumulation of Fluoroquinolones in cells; nervous system damage; psychiatric disorders; reproductive defects; chromosomal abnormality, collagen destruction; aneurysms; HIF degradation; multi organ failure due to UGT, SULT and MRP 2 mutations; cytotoxicity; genotoxicity; diabetes; muscle atrophy; P450/CYP 2E1 dysfunction. Please see our compilation of scientific studies related to the above, in addition to what is on this page:
Multifocal dystonia induced by levofloxacin
https://www.researchgate.net/publication/323218012_Multifocal_dystonia_induced_by_levofloxacin
The effects of ciprofloxacin on male rabbits: Biochemical and histopathological study
https://www.iasj.net/iasj?func=fulltext&aId=112481
Chromosomal aberrations in human lymphocytes exposed in vitro to enrofloxacin and ciprofloxacin
https://pubmed.ncbi.nlm.nih.gov/10048748/
Cytotoxic and genotoxic effects induced by enrofloxacin-based antibiotic formulation Floxagen ® in two experimental models of bovine cells in vitro: peripheral lymphocytes and cumulus cells
https://pubmed.ncbi.nlm.nih.gov/30506381/
Fluoroquinolones are a potent form of chemotherapy
Adverse drug reactions related to the use of fluorquinolone antimicrobials https://www.academia.edu/3597216/Adverse_drug_reactions_related_to_the_use_of_fluoroquinolone_antimicrobials?email_work_card=title
Fluoroquinolone-induced serious, persistent, multisymptom adverse effects
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600819/
4-Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes In Vitro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf
A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods https://www.researchgate.net/publication/40848285
Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity: studies with gemifloxacin, moxifloxacin and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages https://www.ncbi.nlm.nih.gov/pubmed/21764262
Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf
Pharmacokinetic prediction of levofloxacin accumulation in tissue and its association to tendinopathy
https://www.researchgate.net/publication/261759355
Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/pdf/nihms-509241.pdf
Delayed cytotoxicity and cleavage of mitochondrial DNA in ciprofloxacin-treated mammalian cells https://www.ncbi.nlm.nih.gov/pubmed/8913349
Genotoxicity of topoisomerase II inhibitors: an anti-infective perspective
https://www.ncbi.nlm.nih.gov/pubmed/18840496
High-content screening for compounds that affect mtDNA-encoded protein levels in eukaryotic cells
https://www.ncbi.nlm.nih.gov/pubmed/20625181
Role of Mitochondria in Ciprofloxacin-Induced Apoptosis in Murine Sperm Cells
http://eprints.umsu.ac.ir/786/1/1933719113477482.pdf
Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro
http://nmcth.edu/images/gallery/Editorial/xRZVmps_ambulkar.pdf
Exploration of the neurotoxicity of ciprofloxcin or gatifloxacin single dose in rat cortex and hippocampus
http://www.academicjournals.org/article/article1423846203_Arafa%20et%20al.pdf
Risk of hepatotoxicity associated with fluoroquinolones: A national case–control safety study
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