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Fluoroquinolone Toxicity Study, NFP

The Most Important Studies

Regeneration difficulties in patients with FQAD can limit the use of iPSc-based cell therapy

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-02886-0?fbclid=IwAR1k1sKTMNXQ7VU4BcBFXJy7SINvDIAtcuUUpo5IICtv4f7RQCvhbrQ8xTc#Sec2


Relationship of cellular topoisomerase II an inhibition to cytotoxicity

https://www.sciencedirect.com/science/article/pii/S0009279713000057


Fluoroquinolones induced suicidal ideation

http://www.sciencedirect.com/science/article/pii/S0163834309000486?via%3Dihub


Fluoroquinolones cause changes in extracellular matrix, signalling proteins

https://www.ncbi.nlm.nih.gov/pubmed/15890441


Evaluation of photodegradation, phototoxicity and photogenotoxicity

https://www.ncbi.nlm.nih.gov/pubmed/25728226

https://www.sciencedirect.com/science/article/pii/S101113441500041X


Evaluation of ameliorative potential of supranutritional selenium on

https://www.ncbi.nlm.nih.gov/pubmed/27083143


Fluoroquinolone-induced serious, persistent, multi-symptom adverse effects

http://www.dougbremner.com/FQ_Golomb.pdf


Effect of norfloxacin and moxifloxacin on melanin synthesis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf


Flashes, Floaters and Oral Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183446/pdf/nihms519503.pdf


Determination of the Excitatory Potencies of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC105691/pdf/ac001831.pdf


Several gene programs are induced in ciprofloxacin-treated

https://www.ncbi.nlm.nih.gov/pubmed/12949250


Role of Mitochondria in Ciprofloxacin Sperm Cells

http://eprints.umsu.ac.ir/786/1/1933719113477482.pdf


Investigations into the concept of a threshold for topoisomerase

http://www.academia.edu/23099746/Investigations_into_the_concept_of_a_threshold_for_topoisomerase_inhibitor-induced_clastogenicity


Influence on Mitochondria and Cytotoxicity of Different Antibiotics

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797653/pdf/0729-05.pdf


In Vitro induction of micronuclei and chromosome aberrations by quinolones possible

https://www.ncbi.nlm.nih.gov/pubmed/8676903


In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon

http://jpet.aspetjournals.org/content/jpet/308/1/394.full.pdf


High-Content Screening for Compounds That Affect mtDNA-Encoded Protein 

https://www.ncbi.nlm.nih.gov/pubmed/20625181


Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective

https://www.ncbi.nlm.nih.gov/pubmed/18840496


Genotoxic Evaluation of the Antibacterial Drug

http://journals.tubitak.gov.tr/medical/issues/sag-04-34-5/sag-34-5-4-0401-1.pdf


Spectroscopic Studies on the Binding of Some.

https://pdfs.semanticscholar.org/6bfa/b49fd50684b13a85f0b6c7668987a8ad7d55.pdf 


Serum Sickness-Like Illness Associated with Ciprofloxacin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC171716/pdf/aac00061-0258.pdf 


Effect of ciprofloxacin and levofloxacin on some oxidative stress parameters in brain regions of male albino rats

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.893.9513&rep=rep1&type=pdf


Do quinolones bind to DNA? Yes

https://www.sciencedirect.com/science/article/pii/0006295289905054


Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.972.1373&rep=rep1&type=pdf


Damage to mitochondrial DNA induced by the quinolone

https://www.ncbi.nlm.nih.gov/pubmed/10216214


Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones 

https://www.sciencedirect.com/science/article/pii/S1011134400001019


Unnecessary use of fluoroquinolone antibiotics in hospitalized patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145580/pdf/1471-2334-11-187.pdf


The influence of a newly developed quinolone Antofloxacin

https://www.ncbi.nlm.nih.gov/pubmed/18543578


Ciprofloxacin mammalian DNA topoisomerase type II poison in vivo

https://www.sciencedirect.com/science/article/pii/016579929390029U

https://www.ncbi.nlm.nih.gov/pubmed/7678175


Chronic administration of caderofloxacin, a

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf


Bactericidal Antibiotics Induce Mitochondrial Dysfunction

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/pdf/nihms-509241.pdf


Assessment on the adverse effects of Aminoglycosides and Flouroquinolone on sperm 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426151/pdf/ijrm-3-125.pdf


Calcium Signals Are Affected by Ciprofloxacin as a Consequence

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/pdf/1543-05.pdf


Alteration of the endocytotic pathway by photosensitization with fluoroquinolones

http://onlinelibrary.wiley.com/doi/10.1562/0031-8655(2000)0720458AOTEPB2.0.CO2/full


Pharmacokinetic Prediction of Levofloxacin Accumulation

https://www.researchgate.net/publication/261759355_Pharmacokinetic_prediction_of_levofloxacin_accumulation_in_tissue_and_its_association_to_tendinopathy


Adverse Drug Reactions Related to the

https://www.researchgate.net/profile/Roberto_Leone/publication/10945635_Adverse_drug_reactions_related_to_the_use_of_fluoroquinolone_antimicrobials_an_analysis_of_spontaneous_reports_and_fluoroquinolone_consumption_data_from_three_italian_regions/links/0912f50e538574cc25000000/Adverse-drug-reactions-related-to-the-use-of-fluoroquinolone-antimicrobials-an-analysis-of-spontaneous-reports-and-fluoroquinolone-consumption-data-from-three-italian-regions.pdf


2015 Effect of norfloxacin and moxifloxacin on melanin synthesis 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf


Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf


INVESTIGATING EFFECTS OF THE ANTIBIOTIC CIPROFLOXACIN ON THE DOPA

http://scholarworks.umass.edu/masters_theses_2/275/


Drug induced mitochondrial dysfunction Mechanisms and adverse

https://www.ncbi.nlm.nih.gov/pubmed/27771494


Cellular accumulation of fluoroquinolones is not predictive of their intracellular

https://www.ncbi.nlm.nih.gov/pubmed/21764262


Effects of Topoisomerase II-Active Drugs in Mitochondria

http://grantome.com/grant/NIH/R01-GM047535-01A1


Preclinical safety evaluation of moxifloxacin, a novel fluoroquinolone

https://academic.oup.com/jac/article/43/suppl_2/91/2473568


A comparative analysis of chromosomal aberrations in cultured human lymphocytes

https://www.researchgate.net/publication/40848285_A_comparative_analysis_of_chromosomal_aberrations_in_cultured_human_lymphocytes_due_to_fluoroquinolone_drugs_at_different_expression_periods


ACYL GLUCURONIDATION OF FLUOROQUINOLONE ANTIBIOTICS BY THE UDP

https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf


4-Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes in Vitro

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf


Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950664/pdf/gkt1109.pdf


Anti GQ1b IgG antibody - syndrome clinical and immunological range

http://jnnp.bmj.com/content/jnnp/70/1/50.full.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737781/pdf/v072p00418.pdf


ZATT (ZNF451)–mediated resolution

https://www.ncbi.nlm.nih.gov/pubmed/28912134 


A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC529191/pdf/0254-04.pdf


Hereditary Neuropathy Unmasked by Levofloxacin

https://fqresearch.org/pdf_files/hereditary-neuropathy-unmasked-by-levaquin.pdf


Hypersensitivity reactions to fluoroquinolones analysis of the factors

https://www.ncbi.nlm.nih.gov/pubmed/23600547


Genotoxicity of quinolones: substituents contribution and transformation products QSAR evaluation using 2D and 3D models

https://www.ncbi.nlm.nih.gov/pubmed/24080009


Fluoroquinolones-Induced Tendinitis and Tendon

https://www.ncbi.nlm.nih.gov/pubmed/17580216


Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study

https://www.bmj.com/content/360/bmj.k678


Fluoroquinolone toxicity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981197/pdf/cp-2012-4-e87.pdf


Fluoroquinolone resistance

https://www.researchgate.net/publication/268631267_Fluoroquinolone_resistance_in_the_environment_and_the_human_gut_-_Analysis_of_bacterial_DNA_sequences_to_explore_the_underlying_genetic_mechanisms


On the Effect of Covalently Appended Quinolones

https://www.ncbi.nlm.nih.gov/pubmed/11960452


Immunomodulatory Activities of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/16518713

http://www.academia.edu/5656193/Immunomodulatory_Activities_of_Fluoroquinolones


Antibacterial and Anticancer Drugs Interaction with DNA 

https://pdfs.semanticscholar.org/9298/604f37c935936a3e8384829c748af820944a.pdf


Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential

https://www.ncbi.nlm.nih.gov/pubmed/20655887


The photomutagenicity of fluoroquinolones in tests for gene 

https://fqresearch.org/pdf_files/The-photomutagenicity-of-fluoroquinolones-in-tests-for-gene-mutation-chromosomal-aberration-gene-conversion-and-DNA-breakage.pdf


The photomutagenicity of fluoroquinolones 

http://www.sciencedirect.com/science/article/pii/S0378427498002355


The perils of prescribing fluoroquinolones 

http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true

https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf


The neuroprotective role of Nigella sativa extract on

https://www.researchgate.net/publication/266732466_The_neuroprotective_role_of_Nigella_sativa_extract_on_ciprofloxacin_and_pentylenetetrazole_treated_rats


The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglycaemic action

https://www.ncbi.nlm.nih.gov/pubmed/18706903

http://www.sciencedirect.com/science/article/pii/S0014299908008054?via%3Dihub


The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro 

https://www.researchgate.net/profile/YONGJIAN_QI2/publication/51628936_The_effects_of_levofloxacin_on_rabbit_anterior_cruciate_ligament_cells_in_vitro/links/59de3debaca27247d794298f/The-effects-of-levofloxacin-on-rabbit-anterior-cruciate-ligament-cells-in-vitro.pdf


The effect of ciprofloxacin on sperm DNA damage, fertility potential and early

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312808/pdf/vrf-3-131.pdf


The complexes of metal ions with

https://link.springer.com/article/10.1134/S1070328409020018

https://www.researchgate.net/publication/226755953_The_complexes_of_metal_ions_with_fluoroquinolones


Toxic Effects of Levofloxacin on Rat Annulus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237079/pdf/medscimonit-20-2205.pdf


Torsades de pointes associated with fluoroquinolones

http://onlinelibrary.wiley.com/doi/10.1016/j.clpt.2003.11.376/abstract;jsessionid=489433439AB92E1E398D07445C01B2BD.f04t02


Spectrochimica Acta Part A- Molecular and Biomolecular Spectroscopy

https://www.ncbi.nlm.nih.gov/pubmed/23434548


Effect of new synthetically prepared quinolone

http://www.acs.chtf.stuba.sk/papers/acs_0058.pdf


Quinolone-induced arthropathy an update focusing on new mechanistic and clinical

https://www.ncbi.nlm.nih.gov/pubmed/18835137

https://www.sciencedirect.com/science/article/pii/S0924857908003531


Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells 

https://pdfs.semanticscholar.org/0eef/309042885bf1fe3befcf0b5ccb7540840342.pdf


Interaction between ciprofloxacin and DNA mediated by Mg

https://www.sciencedirect.com/science/article/pii/S0020169302009337


Quinolone antibiotics and suicidal behavior analysis of the World

https://www.ncbi.nlm.nih.gov/pubmed/27113226


Effects of Ofloxacin on Integrin Expression

https://www.ncbi.nlm.nih.gov/pubmed/20650069


Cytogenetic alterations in human lymphocyte

http://www.tandfonline.com/doi/full/10.1080/01480545.2016.1188305

https://www.ncbi.nlm.nih.gov/pubmed/27240646


CIPROFLOXACIN INHIBITS PROLIFERATION AND PROMOTES GENERATION OF ANEUPLOIDY IN JURKAT CELLS

http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf


Photosensitizing Mechanism and Identification of Levofloxacin Photoproducts 

https://www.ncbi.nlm.nih.gov/pubmed/22211524

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01068.x/abstract


Photosensitized DNA Damage The Case of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/19320842

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2009.00548.x/abstract


Photosensitization Reactions of Fluoroquinolones and Their Biological

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.00978.x/full

https://www.ncbi.nlm.nih.gov/pubmed/21770950


Pharmacological agents and impairment of fracture healing: What is the evidence 

https://pdfs.semanticscholar.org/7009/158be1562b272f07cc3d7f79fb78dc724c02.pdf


Characterization of Abcc4 Gene Amplification in Stepwise-Selected Mouse J774

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230599/pdf/pone.0028368.pdf


Peripheral Neuropathy Associated with Fluoroquinolones

https://s3.amazonaws.com/academia.edu.documents/46817996/Peripheral_neuropathy_associated_with_fl20160626-31843-131h87p.pdf?AWSAccessKeyId=AKIAIWOWYYGZ2Y53UL3A&Expires=1515092852&

Signature=NIXh4lbUq8h%2BSAy4%2F008wX5IMCM%3D&response-content-disposition=inline%3B%20filename%3DPeripheral_neuropathy_associated_with_fl.pdf


Pathogenesis of Tendon Rupture 

https://www.ncbi.nlm.nih.gov/pubmed/17538473

http://journals.lww.com/orthopaedicnursing/Abstract/2007/05000/Pathogenesis_of_Tendon_Rupture_Secondary_to.9.aspx


Oxidative Damage to RPA Limits the Nucleotide

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669849/pdf/emss-66122.pdf


Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin

http://www.academia.edu/26929187/Oral_toxicity_of_pefloxacin_norfloxacin_ofloxacin_and_ciprofloxacin_comparison_of_biomechanical_and_histopathological_effects_on_Achilles_tendon_in_rats

https://www.ncbi.nlm.nih.gov/pubmed/21628961


Oral Fluoroquinolones and the Risk

https://jamanetwork.com/journals/jama/fullarticle/1148331


Oral Fluoroquinolone and Aortic Dissection and Aortic Aneurysm Risk

http://www.acc.org/latest-in-cardiology/journal-scans/2015/10/06/15/33/risk-of-aortic-dissection-and-aortic-aneurysm-in-patients-taking-oral-fluoroquinolone


Ofloxacin induces oxidative damage to joint chndrocytes of juvenile rabbits

https://www.ncbi.nlm.nih.gov/pubmed/19818344


Ofloxacin induces apoptosis in microencapsulated juvenile rabbit

https://www.ncbi.nlm.nih.gov/pubmed/17961619


Ocular toxicity of fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/17760640


Non-antibiotic-effects-of-fluoroquinolones-in-mammalian-cells

http://www.jbc.org/content/290/36/22287.full.pdf


Exploration of neurotoxicity of ciprofloxin

http://www.academicjournals.org/article/article1423846203_Arafa%20et%20al.pdf


Musculoskeletal Complications of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/21333952


Liquid chromatography–tandem mass spectrometry

http://quimica.udea.edu.co/~carlopez/cromatohplc/hplc_ms_pharma_residues_2005.pdf


ANTIBIOTICS IN PLASMA by LCMS

http://www.eurekaone.com/wp-content/uploads/2013/05/258_LC79010en.pdf

Moxifloxacin-induced multiple organ dysfunction possibly related

http://124.205.33.103:81/ch/reader/create_pdf.aspx?file_no=12-1691&flag=1&year_id=2013&quarter_id=7


Permanent Peripheral Neuropathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528905/pdf/10.1177_2324709614545225.pdf


Lysosomal Membrane Permeabilization Induces Cell Death

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193790/pdf/20021952.pdf


Type II Topoisomerases as Targets for Quinolone Antibacterials

https://www.ncbi.nlm.nih.gov/pubmed/11254893


Possible involvement of DEC1 on the adverse effects of quinolone antibiotics

http://www.myquinstory.info/wp-content/uploads/2010/01/Shi-2010-DEC1.pdf

https://www.ncbi.nlm.nih.gov/pubmed/20214949


Levofloxacin-Induced Autoimmune Hemolytic Anemia

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1004.1741&rep=rep1&type=pdf 

https://www.ncbi.nlm.nih.gov/pubmed/12841809


Concerns about extralabel fluoroquinolone use in food producing animals

https://avmajournals.avma.org/doi/pdf/10.2460/javma.243.9.1242


FDA Warning and Study Highlight

https://jamanetwork.com/journals/jama/article-abstract/1737039?redirect=true


Quinolone-induced Hypoglycemia A

http://www.amjmed.com/article/S0002-9343(09)00871-7/pdf


The Fluoroquinolones How Long Will Their Utility

https://www.ncbi.nlm.nih.gov/pubmed/15061660

http://www.tandfonline.com/doi/abs/10.1080/00365540410019039?journalCode=infd19


Reversible craniocervical dystonia associated with

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710986/pdf/40734_2015_Article_21.pdf


Pathogenesis of quinolone...

https://www.ncbi.nlm.nih.gov/pubmed/15633793


Synergistic Effect of Ofloxacin and Magnesium Deficiency on Joint

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127237/pdf/0776.pdf


Moxifloxacin and ciprofloxacin induces

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531397/pdf/12885_2015_Article_1560.pdf


Melatonin can attenuate ciprofloxacin induced nephrotoxicity

https://www.ncbi.nlm.nih.gov/pubmed/27780148


Levaquin - induce acute psychosis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745871/?report=printable

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745871/


In Vitro Evaluation of Zn–Norfloxacin Complex as a Potent

https://www.ncbi.nlm.nih.gov/pubmed/23636652


Gatifloxacin Induces S and G2-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via p21/p27/p53

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047796


FLUOROQUINOLONE INDUCES HUMAN AORTIC

http://www.onlinecjc.ca/article/S0828-282X(17)30468-3/pdf 


Chronic administration of caderofloxacin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf


Risk of acute kidney injury associated with the use

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708027/pdf/185e475.pdf


Quinolones Action and Resistance Updated

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182077/pdf/CTMC-9-981.pdf


Quinolone-Induced Arthropathy in Neonatal Foals

https://www.researchgate.net/profile/Eden_Bermingham/publication/242317581_Quinolone-Induced_Arthropathy_in_Neonatal_Foals/links/53f1e87b0cf272810e4c74a9.pdf


Quinolone antibacterials a new class of photochemical carcinogens

https://www.ncbi.nlm.nih.gov/pubmed/9085565

http://www.sciencedirect.com/science/article/pii/S1011134496074258?via%3Dihub


Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742585/pdf/kfp163.pdf


Peripheral neuropathy and Guillain-Barré 

https://www.ncbi.nlm.nih.gov/pubmed/24472364

https://www.sciencedirect.com/science/article/pii/S1047279713004754


Oral fluoroquinolones and risk secondary pseudotumor

http://n.neurology.org/content/early/2017/07/28/WNL.0000000000004247.short


Neuropsychiatric reactions to drugs an analysis of spontaneous

https://www.ncbi.nlm.nih.gov/pubmed/15661570


Molecular Analysis of Yeast and Human Type II Topoisomerases

http://www.jbc.org/content/274/40/28246.full.pdf


Interaction between quinolones antibiotics and bacterial outer 

https://www.ncbi.nlm.nih.gov/pubmed/15617818 

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