The Most Important Studies -Fluoroquinolone Adverse Effects
Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review
Mitochondrial dysfunction is underlying fluoroquinolone toxicity: an integrated mitochondrial toxicity assessment
https://link.springer.com/article/10.1007/s13273-022-00263-9
Effects of fluoroquinolones and tetracyclines on mitochondria of human retinal MIO-M1 cells
https://www.sciencedirect.com/science/article/pii/S0014483521004231
Regeneration difficulties in patients with FQAD can limit the use of iPSc-based cell therapy
Fluoroquinolones induced suicidal ideation
http://www.sciencedirect.com/science/article/pii/S0163834309000486?via%3Dihub
Fluoroquinolones cause changes in extracellular matrix, signalling proteins
https://www.ncbi.nlm.nih.gov/pubmed/15890441
Evaluation of photodegradation, phototoxicity and photogenotoxicity
https://www.ncbi.nlm.nih.gov/pubmed/25728226
https://www.sciencedirect.com/science/article/pii/S101113441500041X
Evaluation of ameliorative potential of supranutritional selenium on enrofloxacin-induced testicular toxicity
https://www.ncbi.nlm.nih.gov/pubmed/27083143
Fluoroquinolone-induced serious, persistent, multi-symptom adverse effects
http://www.dougbremner.com/FQ_Golomb.pdf
Effect of norfloxacin and moxifloxacin on melanin synthesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf
Flashes, Floaters and Oral Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183446/pdf/nihms519503.pdf
Determination of the Excitatory Potencies of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC105691/pdf/ac001831.pdf
Several gene programs are induced in ciprofloxacin-treated
https://www.ncbi.nlm.nih.gov/pubmed/12949250
Role of Mitochondria in Ciprofloxacin Sperm Cells
http://eprints.umsu.ac.ir/786/1/1933719113477482.pdf
Investigations into the concept of a threshold for topoisomerase
Influence on Mitochondria and Cytotoxicity of Different Antibiotics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797653/pdf/0729-05.pdf
In Vitro induction of micronuclei and chromosome aberrations by quinolones possible
https://www.ncbi.nlm.nih.gov/pubmed/8676903
In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon
http://jpet.aspetjournals.org/content/jpet/308/1/394.full.pdf
High-Content Screening for Compounds That Affect mtDNA-Encoded Protein
https://www.ncbi.nlm.nih.gov/pubmed/20625181
Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective
https://www.ncbi.nlm.nih.gov/pubmed/18840496
Genotoxic Evaluation of the Antibacterial Drug
http://journals.tubitak.gov.tr/medical/issues/sag-04-34-5/sag-34-5-4-0401-1.pdf
Spectroscopic Studies on the Binding of a New Quinolone Antibacterial Agent: Sinafloxacin to DNA
https://pdfs.semanticscholar.org/6bfa/b49fd50684b13a85f0b6c7668987a8ad7d55.pdf
Serum Sickness-Like Illness Associated with Ciprofloxacin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC171716/pdf/aac00061-0258.pdf
Effect of ciprofloxacin and levofloxacin on some oxidative stress parameters in brain regions of male albino rats
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.893.9513&rep=rep1&type=pdf
Do quinolones bind to DNA? Yes
https://www.sciencedirect.com/science/article/pii/0006295289905054
Delayed cytotoxicity and cleavage of mitochondrial DNA in ciprofloxacin-treated mammalian cells
https://pubmed.ncbi.nlm.nih.gov/8913349/
Damage to mitochondrial DNA induced by the quinolone
https://www.ncbi.nlm.nih.gov/pubmed/10216214
Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones
https://www.sciencedirect.com/science/article/pii/S1011134400001019
Unecessary use of fluoroquinolone antibiotics in hospitalized patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145580/pdf/1471-2334-11-187.pdf
The influence of a newly developed quinolone Antofloxacin
https://www.ncbi.nlm.nih.gov/pubmed/18543578
Ciprofloxacin mammalian DNA topoisomerase type II poison in vivo
https://www.sciencedirect.com/science/article/pii/016579929390029U
https://www.ncbi.nlm.nih.gov/pubmed/7678175
Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1
expression and activity in rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf
Bactericidal Antibiotics Induce Mitochondrial Dysfunction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/pdf/nihms-509241.pdf
Assessment on the adverse effects of Aminoglycosides and Flouroquinolone on sperm parameters and male
reproductive tissue: A systematic review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426151/pdf/ijrm-3-125.pdf
Calcium Signals Are Affected by Ciprofloxacin as a Consequence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/pdf/1543-05.pdf
Alteration of the endocytotic pathway by photosensitization with fluoroquinolones
http://onlinelibrary.wiley.com/doi/10.1562/0031-8655(2000)0720458AOTEPB2.0.CO2/full
Pharmacokinetic Prediction of Levofloxacin Accumulation
Adverse Drug Reactions Related to the
2015 Effect of norfloxacin and moxifloxacin on melanin synthesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf
Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf
INVESTIGATING EFFECTS OF THE ANTIBIOTIC CIPROFLOXACIN ON THE DOPAMINERGIC SH-SY5Y CELL LINE
http://scholarworks.umass.edu/masters_theses_2/275/
Drug induced mitochondrial dysfunction Mechanisms and adverse clinical consequences
https://www.ncbi.nlm.nih.gov/pubmed/27771494
Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity: studies with gemifloxacin, moxifloxacin and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages
https://www.ncbi.nlm.nih.gov/pubmed/21764262
Effects of Topoisomerase II-Active Drugs in Mitochondria
http://grantome.com/grant/NIH/R01-GM047535-01A1
Preclinical safety evaluation of moxifloxacin, a novel fluoroquinolone
https://academic.oup.com/jac/article/43/suppl_2/91/2473568
A comparative analysis of chromosomal aberrations in cultured human lymphocytes
ACYL GLUCURONIDATION OF FLUOROQUINOLONE ANTIBIOTICS BY THE UDP
https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf
4-Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes in Vitro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf
Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2 -dG adduct in the NarI DNA recognition sequence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950664/pdf/gkt1109.pdf
Anti GQ1b IgG antibody - syndrome clinical and immunological range
http://jnnp.bmj.com/content/jnnp/70/1/50.full.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1737781/pdf/v072p00418.pdf
ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links
https://www.ncbi.nlm.nih.gov/pubmed/28912134
A Mutation in Escherichia coli DNA Gyrase Conferring Quinolone Resistance Results in Sensitivity to Drugs Targeting Eukaryotic
Topoisomerase II
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC529191/pdf/0254-04.pdf
Hereditary Neuropathy Unmasked by Levofloxacin
https://fqresearch.org/pdf_files/hereditary-neuropathy-unmasked-by-levaquin.pdf
Hypersensitivity reactions to fluoroquinolones analysis of the factors
https://www.ncbi.nlm.nih.gov/pubmed/23600547
Genotoxicity of quinolones: substituents contribution and transformation products QSAR evaluation using 2D and 3D models
https://www.ncbi.nlm.nih.gov/pubmed/24080009
Fluoroquinolones-Induced Tendinitis and Tendon
https://www.ncbi.nlm.nih.gov/pubmed/17580216
Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study
https://www.bmj.com/content/360/bmj.k678
Fluoroquinolone toxicity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981197/pdf/cp-2012-4-e87.pdf
Fluoroquinolone resistance
On the Effect of Covalently Appended Quinolones on termini of DNA duplexes
https://www.ncbi.nlm.nih.gov/pubmed/11960452
Immunomodulatory Activities of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/16518713
http://www.academia.edu/5656193/Immunomodulatory_Activities_of_Fluoroquinolones
Antibacterial and Anticancer Drugs Interaction with DNA
https://pdfs.semanticscholar.org/9298/604f37c935936a3e8384829c748af820944a.pdf
Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential
https://www.ncbi.nlm.nih.gov/pubmed/20655887
The photomutagenicity of fluoroquinolones in tests for gene
The photomutagenicity of fluoroquinolones
http://www.sciencedirect.com/science/article/pii/S0378427498002355
The perils of prescribing fluoroquinolones
https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf
The neuroprotective role of Nigella sativa extract on
The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglycaemic action
https://www.ncbi.nlm.nih.gov/pubmed/18706903
http://www.sciencedirect.com/science/article/pii/S0014299908008054?via%3Dihub
The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro
The effect of ciprofloxacin on sperm DNA damage, fertility potential and early
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312808/pdf/vrf-3-131.pdf
The complexes of metal ions with
https://link.springer.com/article/10.1134/S1070328409020018
https://www.researchgate.net/publication/226755953_The_complexes_of_metal_ions_with_fluoroquinolones
Toxic Effects of Levofloxacin on Rat Annulus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237079/pdf/medscimonit-20-2205.pdf
Torsades de pointes associated with fluoroquinolones
Spectrochimica Acta Part A- Molecular and Biomolecular Spectroscopy
https://www.ncbi.nlm.nih.gov/pubmed/23434548
Effect of new synthetically prepared quinolone
http://www.acs.chtf.stuba.sk/papers/acs_0058.pdf
Quinolone-induced arthropathy an update focusing on new mechanistic and clinical
https://www.ncbi.nlm.nih.gov/pubmed/18835137
https://www.sciencedirect.com/science/article/pii/S0924857908003531
Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells
https://pdfs.semanticscholar.org/0eef/309042885bf1fe3befcf0b5ccb7540840342.pdf
Interaction between ciprofloxacin and DNA mediated by Mg
https://www.sciencedirect.com/science/article/pii/S0020169302009337
Quinolone antibiotics and suicidal behavior analysis of the World Health Organization's adverse drug reactions database and discussion of potential mechanisms
https://www.ncbi.nlm.nih.gov/pubmed/27113226
Effects of Ofloxacin on Integrin Expression
https://www.ncbi.nlm.nih.gov/pubmed/20650069
Cytogenetic alterations in human lymphocyte
http://www.tandfonline.com/doi/full/10.1080/01480545.2016.1188305
https://www.ncbi.nlm.nih.gov/pubmed/27240646
CIPROFLOXACIN INHIBITS PROLIFERATION AND PROMOTES GENERATION OF ANEUPLOIDY IN JURKAT CELLS
http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf
Photosensitizing Mechanism and Identification of Levofloxacin Photoproducts
https://www.ncbi.nlm.nih.gov/pubmed/22211524
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01068.x/abstract
Photosensitized DNA Damage The Case of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/19320842
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2009.00548.x/abstract
Photosensitization Reactions of Fluoroquinolones and Their Biological
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.00978.x/full
https://www.ncbi.nlm.nih.gov/pubmed/21770950
Pharmacological agents and impairment of fracture healing: What is the evidence
https://pdfs.semanticscholar.org/7009/158be1562b272f07cc3d7f79fb78dc724c02.pdf
Characterization of Abcc4 Gene Amplification in Stepwise-Selected Mouse J774
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230599/pdf/pone.0028368.pdf
Peripheral Neuropathy Associated with Fluoroquinolones
Pathogenesis of Tendon Rupture
https://www.ncbi.nlm.nih.gov/pubmed/17538473
Oxidative Damage to RPA Limits the Nucleotide
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669849/pdf/emss-66122.pdf
Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin
https://www.ncbi.nlm.nih.gov/pubmed/21628961
Oral Fluoroquinolones and the Risk
https://jamanetwork.com/journals/jama/fullarticle/1148331
Oral Fluoroquinolone and Aortic Dissection and Aortic Aneurysm Risk
Ofloxacin induces oxidative damage to joint chndrocytes of juvenile rabbits
https://www.ncbi.nlm.nih.gov/pubmed/19818344
Ofloxacin induces apoptosis in microencapsulated juvenile rabbit
https://www.ncbi.nlm.nih.gov/pubmed/17961619
Ocular toxicity of fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/17760640
Non-antibiotic-effects-of-fluoroquinolones-in-mammalian-cells
http://www.jbc.org/content/290/36/22287.full.pdf
Exploration of neurotoxicity of ciprofloxin
http://www.academicjournals.org/article/article1423846203_Arafa%20et%20al.pdf
Musculoskeletal Complications of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/21333952
Liquid chromatography–tandem mass spectrometry
http://quimica.udea.edu.co/~carlopez/cromatohplc/hplc_ms_pharma_residues_2005.pdf
ANTIBIOTICS IN PLASMA by LCMS
http://www.eurekaone.com/wp-content/uploads/2013/05/258_LC79010en.pdf
Moxifloxacin-induced multiple organ dysfunction possibly related
http://124.205.33.103:81/ch/reader/create_pdf.aspx?file_no=12-1691&flag=1&year_id=2013&quarter_id=7
Permanent Peripheral Neuropathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528905/pdf/10.1177_2324709614545225.pdf
Lysosomal Membrane Permeabilization Induces Cell Death
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193790/pdf/20021952.pdf
Type II Topoisomerases as Targets for Quinolone Antibacterials
https://www.ncbi.nlm.nih.gov/pubmed/11254893
Possible involvement of DEC1 on the adverse effects of quinolone antibiotics
http://www.myquinstory.info/wp-content/uploads/2010/01/Shi-2010-DEC1.pdf
https://www.ncbi.nlm.nih.gov/pubmed/20214949
Levofloxacin-Induced Autoimmune Hemolytic Anemia
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1004.1741&rep=rep1&type=pdf
https://www.ncbi.nlm.nih.gov/pubmed/12841809
Concerns about extralabel fluoroquinolone use in food producing animals
https://avmajournals.avma.org/doi/pdf/10.2460/javma.243.9.1242
FDA Warning and Study Highlight
https://jamanetwork.com/journals/jama/article-abstract/1737039?redirect=true
Quinolone-induced Hypoglycemia A
http://www.amjmed.com/article/S0002-9343(09)00871-7/pdf
The Fluoroquinolones How Long Will Their Utility
https://www.ncbi.nlm.nih.gov/pubmed/15061660
http://www.tandfonline.com/doi/abs/10.1080/00365540410019039?journalCode=infd19
Reversible craniocervical dystonia associated with
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710986/pdf/40734_2015_Article_21.pdf
Pathogenesis of quinolone ...
https://www.ncbi.nlm.nih.gov/pubmed/15633793
Synergistic Effect of Ofloxacin and Magnesium Deficiency on Joint
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127237/pdf/0776.pdf
Moxifloxacin and ciprofloxacin induces
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531397/pdf/12885_2015_Article_1560.pdf
Melatonin can attenuate ciprofloxacin induced nephrotoxicity
https://www.ncbi.nlm.nih.gov/pubmed/27780148
Levaquin - induce acute psychosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745871/?report=printable
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745871/
In Vitro Evaluation of Zn–Norfloxacin Complex as a Potent
https://www.ncbi.nlm.nih.gov/pubmed/23636652
Gatifloxacin Induces S and G2-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via p21/p27/p53
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047796
Fluoroquinolone Induces Human Aortic
http://www.onlinecjc.ca/article/S0828-282X(17)30468-3/pdf
Chronic administration of caderofloxacin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf
Risk of acute kidney injury associated with the use
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708027/pdf/185e475.pdf
Quinolones Action and Resistance Updated
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182077/pdf/CTMC-9-981.pdf
Quinolone-Induced Arthropathy in Neonatal Foals
Quinolone antibacterials a new class of photochemical carcinogens
https://www.ncbi.nlm.nih.gov/pubmed/9085565
http://www.sciencedirect.com/science/article/pii/S1011134496074258?via%3Dihub
Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742585/pdf/kfp163.pdf
Peripheral neuropathy and Guillain-Barré
https://www.ncbi.nlm.nih.gov/pubmed/24472364
https://www.sciencedirect.com/science/article/pii/S1047279713004754
Oral fluoroquinolones and risk secondary pseudotumor
http://n.neurology.org/content/early/2017/07/28/WNL.0000000000004247.short
Neuropsychiatric reactions to drugs an analysis of spontaneous
https://www.ncbi.nlm.nih.gov/pubmed/15661570
Molecular Analysis of Yeast and Human Type II Topoisomerases
http://www.jbc.org/content/274/40/28246.full.pdf
Interaction between quinolones antibiotics and bacterial outer