• Home
  • About Us
  • Fluoroquinolones
    • FDA Warnings
    • EMA Warnings
    • Toxicity Warnings
    • Drug List
    • Chemical Composition
    • Library A-M
    • Library N-Z
    • Most Important Studies
  • Our Research
    • Our Sponsored Research
    • Supporting Studies
  • Find Help
  • Contact Us
  • Disclaimer
  • More
    • Home
    • About Us
    • Fluoroquinolones
      • FDA Warnings
      • EMA Warnings
      • Toxicity Warnings
      • Drug List
      • Chemical Composition
      • Library A-M
      • Library N-Z
      • Most Important Studies
    • Our Research
      • Our Sponsored Research
      • Supporting Studies
    • Find Help
    • Contact Us
    • Disclaimer
  • Home
  • About Us
  • Fluoroquinolones
    • FDA Warnings
    • EMA Warnings
    • Toxicity Warnings
    • Drug List
    • Chemical Composition
    • Library A-M
    • Library N-Z
    • Most Important Studies
  • Our Research
    • Our Sponsored Research
    • Supporting Studies
  • Find Help
  • Contact Us
  • Disclaimer
Fluoroquinolone Toxicity Study, NFP

Welcome to our library A-M

This extensive library of publications below, reflect the work of scientists around the globe.  Segregated by category alphabetically, all relate to either Fluoroquinolone, Quinolone or DNA study.  

If you have found these publications useful, any size contribution to our foundation would be greatly appreciated.

Pay with PayPal or a debit/credit card

ACCUMULATION

Pharmacokinetic prediction of levofloxacin accumulation in tissue and its association to tendinopathy

https://www.researchgate.net/publication/261759355_Pharmacokinetic_prediction_of_levofloxacin_accumulation_in_tissue_and_its_association_to_tendinopathy


Concurrent determination of four fluoroquinolones in catfish, shrimp,  and salmon by liquid chromatography with fluorescence detection

https://www.ncbi.nlm.nih.gov/pubmed/12477191


Screening of Antibiotic Residues in Poultry Liver, Kidney and Muscle in Khartoum State, Sudan

https://pdfs.semanticscholar.org/5640/556fcccf7260990ad15703928eab8db73058.pdf


Factors influencing the intracellular activity of fluoroquinolones:  a study using levofloxacin in a Staphylococcus aureus THP-1 monocyte model https://pubmed.ncbi.nlm.nih.gov/16533826/ 

ADDUCTION/SPECTOGRAPHY/QUINOLONE INTERACTIONS

 

DNA Adduct Profiles

https://www.sciencedirect.com/science/article/pii/S1367593107000701

https://www.ncbi.nlm.nih.gov/pubmed/17574899


DNA Adducts – mutations – cancer

https://www.ncbi.nlm.nih.gov/pubmed/11162720


DNA Adducts Endogenous

http://journals.sagepub.com/doi/pdf/10.1177/019262330002800308


DNA Adduction in Context: Native Metabolic  Activation of Affoobdorne Procarcinogen and Adducted Oligonucleotide  Sequencing Monitored by LC-MS/MS

https://repository.library.northeastern.edu/files/neu:728/fulltext.pdf


DNA Adducts and Their Consequences

https://www-legacy.dge.carnegiescience.edu/SCOPE/SCOPE_52/SCOPE_52_2.01_Beland_29-56.pdf


DNA Adducts: Endogenous and Induced

https://www.ncbi.nlm.nih.gov/pubmed/10862557


Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection

https://www.ncbi.nlm.nih.gov/pubmed/16272169

https://academic.oup.com/carcin/article/27/2/178/2476104


On the Effect of Covalently Appended Quinolones on Termini of DNA Duplexes

http://pubs.acs.org/doi/abs/10.1021/ja0125117


Learn more about DNA Adduct

https://www.sciencedirect.com/topics/neuroscience/dna-adduct


DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes

https://www.ncbi.nlm.nih.gov/pubmed/19122895


Acyl Glucuronidation of fluoroquinolone antibiotics by the udpglucuronosyltransferase 1A subfamily in human liver microsomes

https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf


Antiviral, antifungal, and antiparasitic activities of  fluoroquinolones optimized for treatment of bacterial infections: a  puzzling paradox or a logical consequence of their mode of action?

https://www.ncbi.nlm.nih.gov/pubmed/25515946


Tandem mass spectrometric study of ciprofloxacin–poly(ethylene glycol) conjugate in the presence of alkali metal ions

https://www.sciencedirect.com/science/article/pii/S1387380608002108


Molecular Docking Experiments of 4-Oxotheino [3,2-c] quinoline-2-carboxylates with DNA and their Potential Anticancer Property

https://www.researchgate.net/publication/324834725_Molecular_Docking_Experiments_of_4-Oxotheino_32-c_quinoline-2-carboxylates_with_DNA_and_their_Potential_Anticancer_Property


Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells

https://www.ncbi.nlm.nih.gov/pubmed/23813946


A reply: “Do quinolones bind to DNA” – Yes

https://www.sciencedirect.com/science/article/pii/0006295289905054


Spectroscopic Studies on the Binding of Some Fluoroquinolones with DNA

https://www.ncbi.nlm.nih.gov/pubmed/23434558


Fluoroquinolones stimulate the DNA cleavage activity of  topoisomerase IV by promoting the binding of Mg2+ to the second metal  binding site

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720527/pdf/nihms749655.pdf


Characterization of ciprofloxacin binding to the linear single- and double-stranded DNA

https://www.ncbi.nlm.nih.gov/pubmed/12890558


Mechanism of Quinolone Inhibition of DNA Gyrase

http://www.jbc.org/content/264/5/2973.full.pdf


Interaction between ciprofloxacin and DNA mediated by Mgt + -ions

https://www.ncbi.nlm.nih.gov/pubmed/21820989


Influence of copper(II) and magnesium(II) ions on the ciprofloxacin binding to DNA

http://www.bf.uni-lj.si/fileadmin/groups/2747/Zaposleni/Natasa_Poklar_Ulrih/2003-NPU-JIB.pdf


Interaction between ciprofloxacin and DNA mediated by Mg2_-ions

https://www.sciencedirect.com/science/article/pii/S0020169302009337


Interaction study of ciprofloxacin with human telomeric DNA by spectroscopy and molecular docking

https://www.ncbi.nlm.nih.gov/pubmed/23434548


Structural Insight into a Quinolone-Topoisomerase II-DNA Complex

http://www.jbc.org/content/274/24/17226.full.pdf


The complexes of metal ions with Fluoroquinolones

https://link.springer.com/article/10.1134/S1070328409020018

https://www.researchgate.net/publication/226755953_The_complexes_of_metal_ions_with_fluoroquinolones


Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

http://www.jbc.org/content/270/37/21429.full.pdf


DNA adduct profiles: chemical approaches to addressing the biological impact of DNA damage from small molecules

https://www.ncbi.nlm.nih.gov/pubmed/17574899

https://www.sciencedirect.com/science/article/abs/pii/S1367593107000701?via%3Dihub


DNA adduction in context: native metabolic activation of a foodborne  procarcinogen and adducted oligonucleotide sequencing monitored by  LC-MS/MS

https://www.researchgate.net/publication/45062923_DNA_adduction_in_context_native_metabolic_activation_of_a_foodborne_procarcinogen_and_adducted_oligonucleotide_sequencing_monitored_by_LC-MSMS


DNA Adducts – mutations – cancer

http://aether.cmi.ua.ac.be/artikels/MB_30229.pdf


Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855444/pdf/pone.0010186.pdf


Antibacterial and Anticancer Drugs Interaction with DNA

https://pdfs.semanticscholar.org/9298/604f37c935936a3e8384829c748af820944a.pdf


Effect of metal ions on some pharmacologically relevant interactions involving fl uoroquinolone antibiotics https://www.researchgate.net/profile/Neelam_Seedher/publication/50591479_Effect_of_metal_ions_on_some_pharmacologically_relevant_interactions_involving_fl_uoroquinolone_antibiotics/links/57f4ce4808ae8da3ce54ea48/Effect-of-metal-ions-on-some-pharmacologically-relevant-interactions-involving-fl-uoroquinolone-antibiotics.pdf


DNA Adducts and Their Consequences

https://dge.carnegiescience.edu/SCOPE/SCOPE_52/SCOPE_52_2.01_Beland_29-56.pdf


On the Effect of Covalently Appended Quinolones on Termini of DNA Duplexes

https://www.ncbi.nlm.nih.gov/pubmed/11960452


Synthesis, characterization and DNA binding of magnesium–ciprofloxacin (cfH) complex [Mg(cfl 2]. 2.5H2O

http://www.bf.uni-lj.si/fileadmin/groups/2747/Zaposleni/Natasa_Poklar_Ulrih/2006-NPU-JIB.pdf


DNA Adducts: Endogenous and Induced

https://www.researchgate.net/profile/Andrew_Povey/publication/12455356_DNA_Adducts_Endogenous_and_Induced/links/004635231c89a85c60000000.pdf


Drug bioactivation and protein adduct formation in the pathogenesis of

drug-induced toxicity https://www.researchgate.net/profile/Dominic_Williams2/publication/46287694_Drug_bioactivation_and_protein_adduct_formation_in_the_pathogenesis_of_drug-induced_toxicity/links/59e07a4ca6fdcca98431cbef/Drug-bioactivation-and-protein-adduct-formation-in-the-pathogenesis-of-drug-induced-toxicity.pdf


Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection

https://www.ncbi.nlm.nih.gov/pubmed/16272169


Molecular details of quinolone–DNA interactions: solution structure  of an unusually stable DNA duplex with covalently linked nalidixic acid  residues and non-covalent complexes derived from it

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192833/pdf/gki795.pdf


Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode

http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract


A “Double-Edged” Scaffold Antitumor Power within the Antibacterial Quinolone

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997924/pdf/CMC-23-520.pdf


A theoretical-experimental study on the structure and activity of  certain quinolones and the interaction of their Cu(II)-Complexes on a  DNA model https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365236/pdf/MBD-07-301.pdf


Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequence  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950664/pdf/gkt1109.pdf


Chemo-Targeting_DNA_topoisomerase_II in cancer Chemotherapy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748742/pdf/nihms120024.pdf


Copper(II)–fluoroquinolone complexes with anti-Trypanosoma cruzi activity and DNA binding ability

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746275/pdf/BCA2016-5027404.pdf


Crystal structure, characterisation and biological activity of copper(II)-ciprofloxacin inoic compound https://www.researchgate.net/publication/279899521_Crystal_structure_characterisation_and_biological_activity_of_copperII-ciprofloxacin_ionic_compound


DNA interaction, cytotoxicity, antibacterial and antituberculosis  activity of oxovanadium(IV) complexes derived from fluoroquinolones and  4-hydroxy-5-((4-ydroxyphenyl)diazenyl)thiazole-2(3H)-thione

http://pubs.rsc.org/-/content/articlelanding/2015/ra/c5ra01222h/unauth#!divAbstract


DNA interaction and cytotoxic activities of square planar platinum(II) complexes with N, S-donor ligands.

https://www.ncbi.nlm.nih.gov/pubmed/24632234

https://www.sciencedirect.com/science/article/pii/S1386142514002406?via%3Dihub


Development of a Monoclonal Antibody-Based Broad-Specificity ELISA  for fluoroquinolone Antibiotics in Foods and Molecular Modeling Studies  of Cross-Reactive Compounds

https://www.ncbi.nlm.nih.gov/pubmed/17511422


Norfloxacin La(III)-based complex Synthesis characterization and DNA binding studies

https://www.researchgate.net/publication/279180088_Norfloxacin_LaIII-based_complex_Synthesis_characterization_and_DNA_binding_studies

https://www.tandfonline.com/doi/abs/10.1080/00958972.2015.1065320?journalCode=gcoo20


NMR investigation of pefloxacin/cation/DNA interactions. Mg 2 + and Ca 2 + Binding

https://www.sciencedirect.com/science/article/pii/S037851739700389X


Molecular Analysis of Yeast and Human Type II Topoisomerases

http://www.jbc.org/content/274/40/28246.full.pdf


Mg2 +-Mediated Binding of 6-Substituted Quinolones to DNA: Relevance to Biological Activity

https://www.ncbi.nlm.nih.gov/pubmed/9801827


Quinolones: Action and Resistance Updated

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182077/pdf/CTMC-9-981.pdf


Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.361.8571&rep=rep1&type=pdf


The Structure of DNA-Bound Human Topoisomerase II Alpha:  Gonformational Mechanisms for Goordinating Inter-Subunit Interactions  with DNA Cleavage

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584591/pdf/nihms397579.pdf


The RuvAB Branch Migration Complex Can Displace Topoisomerase IV_Quinolone_DNA Ternary Complexes*

http://www.jbc.org/content/278/48/48485.full.pdf


In Vitro Evaluation of Zn–Norfloxacin Complex as a Potent Cytotoxic and Antibacterial Agent, Proposed Model for DNA Binding

https://www.ncbi.nlm.nih.gov/pubmed/23636652


Pharmacokinetic interactions related to the chemical structures of fluoroquinolones

https://academic.oup.com/jac/article/37/suppl_A/41/816317


Type II Topoisomerases as Targets for Quinolone 

Antibacterials: Turning Dr. Jekyll into Mr. Hyde

https://www.ncbi.nlm.nih.gov/pubmed/11254893

  

Cipro Docking to DNA

https://www.researchgate.net/publication/259871270_International_Journal_of_Research_in_Pharmaceutical_and_Bio_medical_sciences_AJayashree_YSatish_and_M_Anji_Reddy_Molecular_docking_experiments_of_4-oxotheino_32-c_quinoline-2-carboxylates_with_DNA_and

ASSAY TECHNIQUES

 

A one-step chemiluminescence immunoassay for 20 fluoroquinolone  residues in fish and shrimp based on a single chain Fv–alkaline  phosphatase fusion protein

http://pubs.rsc.org/en/Content/ArticleLanding/2015/AY/c5ay01410g#!divAbstract

https://www.researchgate.net/publication/280974405_A_one-step_chemiluminescence_immunoassay_for_20_fluoroquinolone_residues_in_fish_and_shrimp_based_on_a_single_chain_Fv-alkaline_phosphatase_fusion_protein


A simple and rapid high performance liquid chromatography method to  determine levofloxacin in human plasma and its use in a bioequivalence  study

http://www.ddtjournal.com/action/downloaddoc.php?docid=63


Acyl glucuronidation of fluoroquinolone antibiotics by the udpglucuronosyltransferase 1A subfamily in human liver microsomes

https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf


Analytical profile of the fluoroquinolone antibacterials. I. Ofloxacin

https://www.ajol.info/index.php/ajb/article/view/58495/46839


Chemiluminescence competitive indirect enzyme immunoassay for 20  fluoroquinolone residues in fish and shrimp based on a single-chain  variable fragment

https://www.ncbi.nlm.nih.gov/pubmed/23842902

https://link.springer.com/article/10.1007%2Fs00216-013-7174-9

BACTERIAL RESISTANCE

Topoisomerase mutations and efflux are associated with fluoroquinolone resistance in Enterococcus faecalis 

http://www.microbiologyresearch.org/docserver/fulltext/jmm/55/10/1395.pdf?expires=1515012480&id=id&accname=guest&checksum=388D1776DAD602047533F757E7463CE8 

CARCINOGENICITY

Quinolone antibacterials: a new class of photochemical carcinogens

https://www.ncbi.nlm.nih.gov/pubmed/9085565

http://www.sciencedirect.com/science/article/pii/S1011134496074258?via%3Dihub


Study for genotoxicity and carcinogenicity of quinolone antimicrobials in mammals

https://www.researchgate.net/publication/247097248_Study_for_genotoxicity_and_carcinogenicity_of_quinolone_antimicrobials_in_mammals

https://docslide.com.br/documents/study-for-genotoxicity-and-carcinogenicity-of-quinolone-antimicrobials-in-mammals.html


Photochemical mutagenicity of phototoxic and photochemically  carcinogenic fluoroquinolones in comparison with the photostable  moxifloxacin.

https://www.ncbi.nlm.nih.gov/pubmed/11131036

https://link.springer.com/article/10.1007%2Fs002040000162?LI=true

CARDIAC

 

Preclinical safety evaluation of moxifloxacin, a novel fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/10382881


Cardiovascular and metabolic safety profiles of the fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/21958023


Acute and subacute (20-d) oral dose toxicity study of modified fluoroquinolone compound 6C in BALB/c mice

https://www.tandfonline.com/doi/abs/10.3109/15569543.2015.1076483

http://www.tandfonline.com/doi/abs/10.3109/15569543.2015.1076483?src=recsys&journalCode=itxr20


https://www.researchgate.net/publication/281174378_Acute_and_subacute_20-d_oral_dose_toxicity_study_of_modified_fluoroquinolone_compound_6C_in_BALBc_mice?el=1_x_2&enrichId=rgreq-e46136fb-bde7-4077-b86b-ca35779952d6&enrichSource=Y292ZXJQYWdlOzI4MTE3NDM3ODtBUzozNDI3MDQ3MDI2NzI4OTZAMTQ1ODcxODU3NjQ5OQ%3D%3D


Adverse Drug Reactions Related to the Use of Fluoroquinolone Antimicrobials

https://www.researchgate.net/profile/Roberto_Leone/publication/10945635_Adverse_drug_reactions_related_to_the_use_of_fluoroquinolone_antimicrobials_an_analysis_of_spontaneous_reports_and_fluoroquinolone_consumption_data_from_three_italian_regions/links/0912f50e538574cc25000000/Adverse-drug-reactions-related-to-the-use-of-fluoroquinolone-antimicrobials-an-analysis-of-spontaneous-reports-and-fluoroquinolone-consumption-data-from-three-italian-regions.pdf

https://www.ncbi.nlm.nih.gov/pubmed/12534327


Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092995/pdf/hir-17-58.pdf

https://www.ncbi.nlm.nih.gov/pubmed/21818458


Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy

https://www.ncbi.nlm.nih.gov/pubmed/19387967

https://www.ncbi.nlm.nih.gov/pubmed/19387967


Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study

http://bmjopen.bmj.com/content/bmjopen/5/11/e010077.full.pdf


Quinolones: Cardioprocective or Cartiotoxic?

https://www.ncbi.nlm.nih.gov/pubmed/14675020

http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8159.2003.00367.x/abstract

https://www.ncbi.nlm.nih.gov/pubmed/14675020


Relationship of cellular topoisomerase II a inhibition to  cytotoxicity and published genotoxicity of fluoroquinolone antibiotics  in V79 cells

https://www.sciencedirect.com/science/article/pii/S0009279713000057

https://www.ncbi.nlm.nih.gov/pubmed/23340199


Synthesis, characterization, antimicrobial, SODmimic and DNA  interaction behavior of copper(II) complexes with pefloxacin and  phenanthroline derivatives

http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0149198&type=printable

https://onlinelibrary.wiley.com/doi/abs/10.1002/aoc.1766


Effect of Macrolide and Fluoroquinolone Antibacterials on the Risk of Ventricular Arrhythmia and Cardiac Arrest

https://www.researchgate.net/profile/Hernan_Polo_Friz/publication/24033863_Effect_of_Macrolide_and_Fluoroquinolone_Antibacterials_on_the_Risk_of_Ventricular_Arrhythmia_and_Cardiac_Arrest/links/54f6e7f50cf27d8ed71ff251.pdf

https://www.ncbi.nlm.nih.gov/pubmed/19236122


Quinolone induced QT interval prolongation: a not-so-unexpected class effect

https://www.ncbi.nlm.nih.gov/pubmed/10797074


Oral Fluoroquinolone and Aortic Dissection and Aortic Aneurysm Risk

https://www.ncbi.nlm.nih.gov/pubmed/26436523

http://www.acc.org/latest-in-cardiology/journal-scans/2015/10/06/15/33/risk-of-aortic-dissection-and-aortic-aneurysm-in-patients-taking-oral-fluoroquinolone


Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/26436523

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2451282


Risks of Cardiac Arrhythmia and Mortality Among Patients Using New-Generation

Macrolides, Fluoroquinolones, and β-Lactam/ β-Lactamase Inhibitors: A Taiwanese Nationwide Study

https://www.ncbi.nlm.nih.gov/pubmed/25409476


Safety issues and drug—drug interactions with commonly used quinolones

https://www.ncbi.nlm.nih.gov/pubmed/25423877

https://www.researchgate.net/publication/268816291_Safety_issues_and_drug-drug_interactions_with_commonly_used_quinolones


Torsades de pointes associated with fluoroquinolones: Importance of concomitant risk factors

https://www.ncbi.nlm.nih.gov/pubmed/15001976


http://onlinelibrary.wiley.com/doi/10.1016/j.clpt.2003.11.376/abstract;jsessionid=489433439AB92E1E398D07445C01B2BD.f04t02


The perils of prescribing fluoroquinolones

https://www.mdedge.com/familymedicine/article/65086/perils-prescribing-fluoroquinolones

http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true

https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf


The Safety Profile of the Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/10945507


The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel

https://www.ncbi.nlm.nih.gov/pubmed/23711922

http://www.sciencedirect.com/science/article/pii/S0960894X13005647?via%3Dihub


Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

https://www.ncbi.nlm.nih.gov/pubmed/24410307


Toxicological Assessment of Trace b-Diketone Antibiotic Mixtures on Zebrafish (Danio rerio) by Proteomic Analysis

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102731

https://www.ncbi.nlm.nih.gov/pubmed/25062015

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111491/pdf/pone.0102731.pdf


Mechanism of hERG Kþ channel blockade by the fluoroquinolone antibiotic moxifloxacin

https://www.ncbi.nlm.nih.gov/pubmed/16474415

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1760709/pdf/147-0706678a.pdf


Fluoroquinolones May Increase Aortic Aneurysm Risk

https://www.medpagetoday.com/cardiology/prevention/53950


Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect – comprehensive overview of clinical trials

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785617/pdf/40360_2016_Article_53.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26960809


Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419912/pdf/bph0166-1694.pdf

https://www.ncbi.nlm.nih.gov/pubmed/22289150


The effect of levofloxacin and moxifloxacin on cardiovascular functions of rats with  streptozotocin induced diabetes

https://www.ncbi.nlm.nih.gov/pubmed/22621918


Fluoroquinolone induces human aortic fibroblast-mediated extracellular matrix dysregulation

http://www.onlinecjc.ca/article/S0828-282X(17)30468-3/pdf

https://www.onlinecjc.ca/article/S0828-282X(17)30468-3/abstract


Safety of fluoroquinolones: An update

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/pdf/JID13054.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/


The Quinolones, Ch 16, Prospects

https://www.sciencedirect.com/science/article/pii/B9780120595174500179


Rates of Torsades de Pointes Associated with Ciprofloxacin, Ofloxacin, Levofloxacin, Gatifloxacin, and Moxifloxacin

https://www.ncbi.nlm.nih.gov/pubmed/11765299

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.20.1468.34482/abstract


Fluoroquinolone Adverse Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691


Sparfloxacin, a Fluoroquinolone Antibiotic, Slows Inactivation of L-Type a2D C Current in Neonatal Rat Ventricular Myocytes

http://www.cell.com/biophysj/pdf/S0006-3495(14)01834-7.pdf

  

New Evidence Against Use of Fluoroquinolones in Aortic Disease

https://www.medscape.com/viewarticle/949358  

  

Effects of Fluroquinolone Exposure on Aortic Dissection, Aneurysm Outcomes  

https://www.thecardiologyadvisor.com/home/topics/valvular-heart-disease/patients-with-aortic-dissection-or-aneurysm-exposed-to-fluroquinolones-have-poorer-clinical-outcomes-and-increased-mortality/?fbclid=IwAR1cCT_24vrc6TrooV0ESNeEacdv8tH0YxwAVX1J05kCb1k7Rycr2JLNhn0


Oral fluoroquinolones and risk of aortic or mitral regurgitation: A nationwide nested case-control study 

https://www.mdlinx.com/journal-summary/oral-fluoroquinolones-and-risk-of-aortic-or-mitral-regurgitation-a-nationwide-nested-case-control/33z14fFIonrvjSaPXR3KIU 

  

Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study

https://bmjopen.bmj.com/content/5/11/e010077?fbclid=IwAR2Gs9V04kQInAwjKAJ0i-Ae6rxGoW5LXZAsid9NXKwCjXbqqGMrg4FLcXw

CARTILAGE

 

Clinical toxicological aspects of fluoroquinolones

http://fqvictims.org/fqvictims/News/Clinical%20Toxicological%20Aspects%20of%20FQs/Clinical%20Toxicological%20Aspects%20of%20Fluroquinolones.pdf


Comparative Evaluation of Ultrastructural Changes in Articular  Cartilage of Ofioxacin-Treated and Magnesium-Deficient Immature Rats*

https://www.ncbi.nlm.nih.gov/pubmed/8923679


Confirmation of fluoroquinolone residues in salmon and shrimp tissue  by LC/MS: Evaluation of single quadrupole and ion trap instruments

https://www.researchgate.net/publication/237526315_Confirmation_of_fluoroquinolone_residues_in_salmon_and_shrimp_tissue_by_LCMS_Evaluation_of_single_quadrupole_and_ion_trap_instruments

CHEMISTRY

 

Investigating the fluoroquinolone-topoisomerase interaction by use of novel fluoroquinolone and quinazoline analogs

http://ir.uiowa.edu/cgi/viewcontent.cgi?article=2403&context=etd

https://ir.uiowa.edu/etd/1018/


The Complexes of Metal Ions with Fluoroquinolones

https://link.springer.com/article/10.1134/S1070328409020018

https://www.researchgate.net/publication/226755953_The_complexes_of_metal_ions_with_fluoroquinolones?el=1_x_2&enrichId=rgreq-3b3141eb-c68c-447f-8565-30c9ccb9ac66&enrichSource=Y292ZXJQYWdlOzIyNjc1NTk1MztBUzozMzk1Mzc2OTI3NzQ0MDJAMTQ1Nzk2MzUwMjQ5MQ%3D%3D


Synthesis, characterization, antimicrobial and cytotoxicity studies of some transition metal complexes with gemifloxacin

https://link.springer.com/article/10.1007/s00706-015-1507-7

https://www.researchgate.net/publication/282539276_Synthesis_characterization_antimicrobial_and_cytotoxicity_studies_of_some_transition_metal_complexes_with_gemifloxacin

http://www.academia.edu/27979159/Synthesis_characterization_antimicrobial_and_cytotoxicity_studies_of_some_transition_metal_complexes_with_gemifloxacin


A comparative analysis of chromosomal aberrations in cultured human  lymphocytes due to fluoroquinolone drugs at different expression periods

https://link.springer.com/article/10.1007/s00204-009-0509-9

https://www.ncbi.nlm.nih.gov/pubmed/20049419


Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode

https://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f

https://www.researchgate.net/publication/285630343_CopperI_complexes_with_phosphine_derived_from_sparfloxacin_Part_II_a_first_insight_into_the_cytotoxic_action_mode


Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones-Shaping the Fifth Generation  https://pubmed.ncbi.nlm.nih.gov/34452252/ 

CHONDROCYTES

 

Comparative Evaluation of Ultrastructural Changes in Articular  Cartilage of Ofloxacin-Treated and Magnesium-Deficient Immature Rats*

https://www.ncbi.nlm.nih.gov/pubmed/8923679

CLINICAL STUDY

Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro

http://www.nmcth.edu/images/gallery/Editorial/xRZVmps_ambulkar.pdf


Fluoroquinolones and Musculoskeletal Toxicity in Pediatrics: Is The Fear Real?

http://sites.utexas.edu/pharmacotherapy-rounds/files/2015/09/kuriakose11-21-14.pdf


Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092995/pdf/hir-17-58.pdf

https://www.ncbi.nlm.nih.gov/pubmed/21818458


Diagnostic failure of ciprofloxacin-induced spontaneous bilateral  Achilles tendon rapture: case-reported and medical legal consideration

https://www.ncbi.nlm.nih.gov/pubmed/21658328


Emergency Department Visits for Antibiotic- Associated Adverse Events

https://www.ncbi.nlm.nih.gov/pubmed/18694344

https://pdfs.semanticscholar.org/1899/bafdc7edb82d8a70c042bf015db299a2a5b3.pdf


Severe hypoglycemia associated with levofloxacin in Type 2 diabetic patients receiving polytherapy: two case reports

https://www.ncbi.nlm.nih.gov/pubmed/22456302


Ciprofloxacin-associated choreoathetosis in a haemodialysis patient

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645130/pdf/bcr-2013-009293.pdf.

https://www.ncbi.nlm.nih.gov/pubmed/23605987


Unnecessary use of fluoroquinolone antibiotics in hospitalized patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145580/pdf/1471-2334-11-187.pdf

https://www.ncbi.nlm.nih.gov/pubmed/21729289


US-Based Emergency Department Visits for Fluoroquinolone-Associated Hypersensitivity Reactions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635672/pdf/nihms732049.pdf

https://www.ncbi.nlm.nih.gov/pubmed/23963962


Crystal-induced acute kidney injury due to ciprofloxacin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316583/pdf/JNP-4-29.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316583/


Characterization of N-Glucuronidation of 4-(5-Pyridin-4-yl-1H– [1,2,4]triazol-3-yl)pyridine-2-carbonitrile (FYX-051): A New Xanthine Oxidoreductase Inhibitor

http://dmd.aspetjournals.org/content/dmd/35/12/2143.full.pdf

https://www.ncbi.nlm.nih.gov/pubmed/17761779


The Risk of Hepatotoxicity with Fluoroquinolones: A National Case-Control Safety Study

https://pdfs.semanticscholar.org/d8b9/369765128c9e72b8253900ac18953b469ead.pdf?_ga=2.31586366.1053620723.1561154198-51003240.1552665781

https://www.semanticscholar.org/paper/The-Risk-of-Hepatotoxicity-with-Fluoroquinolones-%3A-Morrill-Caffrey/d8b9369765128c9e72b8253900ac18953b469ead

CNS PNS ANS Neural (see also Neural)

Preclinical safety evaluation of moxifloxacin, a novel fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/10382881


Reversible craniocervical dystonia associated with levofloxacin

https://clinicalmovementdisorders.biomedcentral.com/articles/10.1186/s40734-015-0021-8 

COLLAGEN MUTATION AND HIF GEGRADATION

Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26205818


New insights in extracellular matrix  remodeling and collagen turnover related pathways in cultured human  tenocytes after ciprofloxacin administration

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838320/ 

CORNEAL CYTOTOXICITY (see ocular)

Concentrations of the des-F(6)-quinolone garenoxacin in plasma and joint cartilage of immature rats

https://www.ncbi.nlm.nih.gov/pubmed/14661070

CYTOTOXITY

Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro

http://www.nmcth.edu/images/gallery/Editorial/xRZVmps_ambulkar.pdf

https://www.ncbi.nlm.nih.gov/pubmed/20334059


4-Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes In Vitro

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/


A comparative analysis of chromosomal aberrations in cultured human  lymphocytes due to fluoroquinolone drugs at different expression periods

https://www.researchgate.net/publication/40848285_A_comparative_analysis_of_chromosomal_aberrations_in_cultured_human_lymphocytes_due_to_fluoroquinolone_drugs_at_different_expression_periods

https://www.ncbi.nlm.nih.gov/pubmed/20049419


Alteration of the Endocytotic Pathway by Photosensitization with Fluoroquinolones

http://onlinelibrary.wiley.com/doi/10.1562/0031-8655(2000)0720458AOTEPB2.0.CO2/full

https://www.ncbi.nlm.nih.gov/pubmed/11045714


Effects of Difloxacin on the Metabolism of Glycosaminoglycans and Collagen in Organ Cultures of Articular Cartilage

https://www.sciencedirect.com/science/article/pii/S0272059083710341


Calcium Signals Are Affected by Ciprofloxacin as a Consequence of Reduction of Mitochondrial DNA Content in Jurkat Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/pdf/1543-05.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/


Antiviral, antifungal, and antiparasitic activities of  fluoroquinolones optimized for treatment of bacterial infections: a  puzzling paradox or a logical consequence of their mode of action?

https://www.ncbi.nlm.nih.gov/pubmed/25515946


Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test

https://hal.archives-ouvertes.fr/hal-01191262/document

https://www.ncbi.nlm.nih.gov/pubmed/22047769


Assessment on the adverse effects of Aminoglycosides and  Flouroquinolone on sperm parameters and male reproductive tissue: A  systematic review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426151/pdf/ijrm-3-125.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26000002


Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/pdf/nihms-509241.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/


Biological activities of some Fluoroquinolones-metal complexes

https://www.researchgate.net/publication/270538458_Biological_activities_of_some_Fluoroquinolones-metal_complexes?el=1_x_2&enrichId=rgreq-52a57dae-60a0-4e3d-ae56-a986c57656e1&enrichSource=Y292ZXJQYWdlOzI3MDUzODQ1ODtBUzozNzA0MjIwNjQ0MDI0NDBAMTQ2NTMyNjkxMDg1Ng%3D%3D

https://www.ajol.info/index.php/ijmbr/article/view/91824


Butachlor induced dissipation of mitochondrial membrane potential,  oxidative DNA damage and necrosis in human peripheral blood mononuclear  cells

https://www.ncbi.nlm.nih.gov/pubmed/22884430


Copper(II) complexes with norfloxacin and neutral terpyridines:  Cytotoxic, antibacterial, superoxide dismutase and DNA-interaction  approach

https://www.sciencedirect.com/science/article/pii/S0277538712002112


Ciprofloxacin induced chondrotoxicity and tendinopathy

 http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.925.203&rep=rep1&type=pdf

https://pdfs.semanticscholar.org/31e5/c6845352b87aba23c60b714d7253cc2ab2de.pdf


Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms

https://www.ncbi.nlm.nih.gov/pubmed/25902267


Combined Use of In Vitro Phototoxic Assessments and Cassette Dosing  Pharmacokinetic Study for Phototoxicity Characterization of  Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160149/pdf/12248_2011_Article_9292.pdf

https://www.ncbi.nlm.nih.gov/pubmed/21739333


Comparison of fluoroquinolones: cytotoxicity on human corneal epithelial cells

https://www.nature.com/articles/eye2009179.pdf

https://www.ncbi.nlm.nih.gov/pubmed/19648900


Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells

https://www.ncbi.nlm.nih.gov/pubmed/23813946


Cytotoxicity of Quinolones toward Eukaryotic Cells

http://www.jbc.org/content/267/19/13150.full.pdf

https://www.ncbi.nlm.nih.gov/pubmed/1320012

  

Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.972.1373&rep=rep1&type=pdf


Effect of levofloxacin on glycosaminoglycan and DNA synthesis of cultured rabbit 

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.845.2627&rep=rep1&type=pdf


Gene expression profiles in the articular cartilage of juvenile rats receiving the 

https://www.ncbi.nlm.nih.gov/pubmed/18572299


Lysosomal Membrane Permeabilization Induces Cell Death

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193790/pdf/20021952.pdf


In vitro study of cytotoxicity of quinolones on rabbit tenocytes 

https://link.springer.com/article/10.1023/A:1007435025616


In Vitro Evidence for Effects of Magnesium Supplementation on

https://www.ncbi.nlm.nih.gov/pubmed/11280370


Fluoroquinolone Induced Tendinopathy

https://www.jstage.jst.go.jp/article/tjem/226/4/226_4_251/_pdf


Fluoroquinolones cause changes in extracellular matrix, signalling proteins,

https://www.ncbi.nlm.nih.gov/pubmed/15890441


Evaluation of gatifloxacin for eye

https://www.ncbi.nlm.nih.gov/pubmed/25028261

http://journals.sagepub.com/doi/abs/10.1177/0960327114530743


 Evaluation of ameliorative potential of supranutritional selenium on

https://www.ncbi.nlm.nih.gov/pubmed/27083143


Effects of Ofloxacin in Integrin Expression

https://www.ncbi.nlm.nih.gov/pubmed/20650069


Effects of fluoroquinolones and glucocorticoids on cultivated tendon cells in vitro 

https://www.ncbi.nlm.nih.gov/pubmed/20650258


Effect of various concentrations of antibiotics on osteogenic cell viability and activity 

https://www.ncbi.nlm.nih.gov/pubmed/21567453


Effect of norfloxacin and moxifloxacin on melanin synthesis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf


Drug induced liver injury Interactions between drug properties

https://www.ncbi.nlm.nih.gov/pubmed/25912521


Drug features that contribute to the activity of quinolones against mammalian 

http://www.myquinstory.info/wp-content/uploads/2013/09/Activity-of-Quinolones-Mammalian-Cells.pdf


Detection and Prevention of Ocular Phototoxicity of Ciprofloxacin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910230/pdf/nihms-204214.pdf


Several gene programs are induced in ciprofloxacin-treated

https://www.ncbi.nlm.nih.gov/pubmed/12949250


Role of Mitochondria in Ciprofloxacin Sperm Cells

http://eprints.umsu.ac.ir/786/1/1933719113477482.pdf


Investigations into the concept of a threshold for topoisomerase

https://academic.oup.com/mutage/article/18/4/345/1079374

  

Influence on Mitochondria and Cytotoxicity of Different Antibiotics 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797653/pdf/0729-05.pdf


In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon

http://jpet.aspetjournals.org/content/jpet/308/1/394.full.pdf


Genotoxicity of topoisomerase II inhibitors An anti-infective perspective

https://www.ncbi.nlm.nih.gov/pubmed/18840496


Recent Advances in the Discovery and Development of Quinolones and Analogues as

https://www.researchgate.net/publication/13079523_Recent_Advances_in_the_Discovery_and_Development_of_Quinolones_and_Analogues_as_Antitumor_Agents

https://books.google.com/books?hl=en&lr=&id=SJoxUN91vK4C&oi=fnd&pg=PA179#v=onepage&q&f=false


Effect of new synthetically prepared quinolone

http://www.acs.chtf.stuba.sk/papers/acs_0058.pdf


Quinolone-induced arthropathy an update focusing on new mechanistic and clinical

https://www.ncbi.nlm.nih.gov/pubmed/18835137

https://www.sciencedirect.com/science/article/pii/S0924857908003531


Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells 

https://pdfs.semanticscholar.org/0eef/309042885bf1fe3befcf0b5ccb7540840342.pdf


Quinolone Antibiotics Induce Shiga Toxin

https://www.ncbi.nlm.nih.gov/pubmed/10669353

https://academic.oup.com/jid/article/181/2/664/824154


Effects of Ofloxacin on Integrin Expression

https://www.ncbi.nlm.nih.gov/pubmed/20650069


Cytogenetic alterations in human lymphocyte

http://www.tandfonline.com/doi/full/10.1080/01480545.2016.1188305

https://www.ncbi.nlm.nih.gov/pubmed/27240646


CIPROFLOXACIN INHIBITS PROLIFERATION AND PROMOTES

http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf


Photosensitizing Mechanism and Identification of Levofloxacin Photoproducts at

https://www.ncbi.nlm.nih.gov/pubmed/22211524

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01068.x/abstract


Photosensitization Reactions of Fluoroquinolones and Their Biological

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.00978.x/full

https://www.ncbi.nlm.nih.gov/pubmed/21770950


Oxidative stress response of two fluoroquinolones with catalase and 

https://www.ncbi.nlm.nih.gov/pubmed/23542600 

  

Oxidative Damage to RPA Limits the Nucleotide

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669849/pdf/emss-66122.pdf


Ofloxacin induces oxidative damage to joint chndrocytes of juvenile rabbits. Excessive

https://www.ncbi.nlm.nih.gov/pubmed/19818344


Ofloxacin induces apoptosis in microencapsulated juvenile rabbit

https://www.ncbi.nlm.nih.gov/pubmed/17961619


Ocular toxicity of fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/17760640


Non-antibiotic-effects-of-fluoroquinolones-in-mammalian-cells

http://www.jbc.org/content/290/36/22287.full.pdf


Nalidixic Acid, Oxolinic Acid, and Novobiocin Inhibit

https://www.ncbi.nlm.nih.gov/pubmed/7017932


Musculoskeletal Complications of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/21333952


Moxifloxacin-induced multiple organ dysfunction possibly related

http://124.205.33.103:81/ch/reader/create_pdf.aspx?file_no=12-1691&flag=1&year_id=2013&quarter_id=7


Inhibitory Effects of Quinolones on Pro- and Eucaryotic DNA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC171971/pdf/aac00066-0125.pdf


Copper complexes with phosphine derived

http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract


DNA topoisomerase targets of the fluoroquinolones

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC28420/pdf/pq013991.pdf


Cytotoxic effects and apoptosis induction of enrofloxacin in hepatic 

https://www.ncbi.nlm.nih.gov/pubmed/26475364


Voreloxin Is an Anticancer Quinolone Derivative that

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855444/pdf/pone.0010186.pdf


Ultrastructural characterization of murine

https://link.springer.com/article/10.1007%2Fs00204-001-0293-7?LI=true


Ultrastructural changes induced by the des-F(7)-quinolone garenoxacin

https://www.ncbi.nlm.nih.gov/pubmed/12811465

https://link.springer.com/article/10.1007/s00204-003-0478-3


Ultrastructural Changes in Articular Cartilages of

http://journals.sagepub.com/doi/pdf/10.1177/030098589202900307


Trovafloxacin Enhances Lipopolysaccharide-Stimulated

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056269/pdf/jpet.114.214189.pdf


Toxicological Assessment of Trace b-Diketone Antibiotic

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111491/pdf/pone.0102731.pdf


 Toxic Effects of Quinolone Antibacterial Agents on the musculoskeletal system in juvenile rats  

 https://www.ncbi.nlm.nih.gov/pubmed/9437810


Third and Fourth Generation Fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/24410307


The Safety Prifile of the Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/10945507


The perils of prescribing fluoroquinolones 

http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true

https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf


The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglyc

https://www.ncbi.nlm.nih.gov/pubmed/18706903

http://www.sciencedirect.com/science/article/pii/S0014299908008054?via%3Dihub


The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro 

https://www.researchgate.net/profile/YONGJIAN_QI2/publication/51628936_The_effects_of_levofloxacin_on_rabbit_anterior_cruciate_ligament_cells_in_vitro/links/59de3debaca27247d794298f/The-effects-of-levofloxacin-on-rabbit-anterior-cruciate-ligament-cells-in-vitro.pdf


The effect of ciprofloxacin on sperm DNA damage, fertility potential and early

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312808/pdf/vrf-3-131.pdf


Toxic Effects of Levofloxacin on Rat Annulus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237079/pdf/medscimonit-20-2205.pdf


Synergistic effects of dexamethasone and quinolones on human-derived (1)

https://www.ncbi.nlm.nih.gov/pubmed/20034766

http://www.ijaaonline.com/article/S0924-8579(09)00483-X/fulltext


Generalized Seizure and Toxic Epidermal Necrolysis Following

https://www.researchgate.net/profile/Tabo_Sikaneta/publication/7910080_Generalized_Seizure_and_Toxic_Epidermal_Necrolysis_Following_Levofloxacin_Exposure/links/0c96053ac9095855c8000000/Generalized-Seizure-and-Toxic-Epidermal-Necrolysis-Following-Levofloxacin-Exposure.pdf


Safety of fluoroquinolones update

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/pdf/JID13054.pdf


Pathogenesis of quinolone

https://www.ncbi.nlm.nih.gov/pubmed/15633793


Piperonal ciprofloxacin hydrazone induces growth

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010342/pdf/aps2011158a.pdf


Moxifloxacin and ciprofloxacin induces

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531397/pdf/12885_2015_Article_1560.pdf


Metal Complexes of Quinolone Antibiotics and Their Applications

http://www.mdpi.com/1420-3049/18/9/11153/htm


Melatonin can attenuate ciprofloxacin induced nephrotoxicity

https://www.ncbi.nlm.nih.gov/pubmed/27780148


In Vitro Evaluation of Zn–Norfloxacin Complex as a Potent

https://www.ncbi.nlm.nih.gov/pubmed/23636652


Gatifloxacin Induces S and G2 -phase cell cycle  arrest

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047796


Chronic administration of caderofloxacin,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf


Trimethoxy-benzaldehyde levofloxacin hydrazine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716872/pdf/1475-2867-13-67.pdf


Quinolone arthropathy in immature rabbits treated with the fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/8811288

http://www.sciencedirect.com/science/article/pii/S0940299396800030?via%3Dihub


Probing the binding of two fluoroquinolones to lysozyme a combined

https://www.researchgate.net/publication/221791544_Probing_the_binding_of_two_fluoroquinolones_to_lysozyme_A_combined_spectroscopic_and_docking_study


Pro-apoptotic effect of new quinolone

https://www.sciencedirect.com/science/article/pii/S0887233316300285

https://www.ncbi.nlm.nih.gov/pubmed/26916084


Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742585/pdf/kfp163.pdf


Investigation of fluoroquinolone-induced myalgia

http://onlinelibrary.wiley.com/doi/10.1002/art.10094/pdf


Fluoroquinolone-Mediated Inhibition of Cell Growth

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424257/pdf/pone.0042960.pdf


Treatment of the Fluoroquinolone Associated Disability –

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf

https://www.hindawi.com/journals/omcl/2017/8023935/


A “Double-Edged” Scaffold Antitumor Power within the Antibacterial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997924/pdf/CMC-23-520.pdf


Effects of Novel Fluoroquinolones on the Catalytic Activities of

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC189387/pdf/aac00038-0087.pdf


Possible involvement of DEC1 on the adverse effects of quinolone antibiotics!!!

http://www.myquinstory.info/wp-content/uploads/2010/01/Shi-2010-DEC1.pdf

https://www.ncbi.nlm.nih.gov/pubmed/20214949


Fluoroquinolone Adverse Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691


Embryotoxicity of Fluroroquinolones in Rats

https://www.researchgate.net/publication/313676604_EMBRYOTOXICITY_OF_FLUOROQUINOLONES_IN_RATS

DERMAL

Phototoxic Lesions Induced by Quinolone Antibacterial Agents in Auricular Skin and Retina of Albino Mice*

https://www.ncbi.nlm.nih.gov/pubmed/8052802


Effect of norfloxacin and moxifloxacin on melanin synthesis and antioxidant enzymes activity in normal human melanocytes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf

https://www.ncbi.nlm.nih.gov/pubmed/25433710


Adverse Drug Reactions Related to the Use of Fluoroquinolone  Antimicrobials: An Analysis of Spontaneous Reports and Fluoroquinolone  Consumption Data from Three Italian Regions

https://www.researchgate.net/profile/Roberto_Leone/publication/10945635_Adverse_drug_reactions_related_to_the_use_of_fluoroquinolone_antimicrobials_an_analysis_of_spontaneous_reports_and_fluoroquinolone_consumption_data_from_three_italian_regions/links/0912f50e538574cc25000000/Adverse-drug-reactions-related-to-the-use-of-fluoroquinolone-antimicrobials-an-analysis-of-spontaneous-reports-and-fluoroquinolone-consumption-data-from-three-italian-regions.pdf

https://www.ncbi.nlm.nih.gov/pubmed/12534327


Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/11195848


Cutaneous leukocytoclastic vasculitis associated with levofloxacin therapy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892663/pdf/idr-2012-1-e11.pdf

https://www.ncbi.nlm.nih.gov/pubmed/24470918


Effect of norfloxacin and moxifloxacin on melanin synthesis and antioxidant enzymes activity in normal human melanocytes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf

https://www.ncbi.nlm.nih.gov/pubmed/25433710


Evaluation of photodegradation, phototoxicity and photogenotoxicity of ofloxacin in ointments with sunscreens and in solutions

https://www.ncbi.nlm.nih.gov/pubmed/25728226

https://www.sciencedirect.com/science/article/pii/S101113441500041X


Formation of Antigenic Photoadducts on Langerhans Cells Photoallergy to Systemically Administered Quinolone in Mice

http://www.sciencedirect.com/science/article/pii/S0022202X15408115

https://www.ncbi.nlm.nih.gov/pubmed/10692119


Ofloxacin Induced Cutaneous Reactions in Children

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525525/pdf/jcdr-9-FD01.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525525/


Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669849/pdf/emss-66122.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26134950


Cutaneous Vasculitis Associated with Fluoroquinolones

http://edoc.unibas.ch/25010/1/s15010-009-8437-4.pdf

https://www.ncbi.nlm.nih.gov/pubmed/19669086


Stimulation of Prostaglandin Production by Quinolone Phototoxicity in Balb/c 3T3 Mouse Fibroblast Cells in Vitro

https://www.ncbi.nlm.nih.gov/pubmed/9143485

https://www.sciencedirect.com/science/article/pii/S0272059096922824


Safety issues and drug—drug interactions with commonly used quinolones

https://www.ncbi.nlm.nih.gov/pubmed/25423877

https://www.researchgate.net/publication/268816291_Safety_issues_and_drug-drug_interactions_with_commonly_used_quinolones


The photomutagenicity of fluoroquinolones and other drugs

http://www.sciencedirect.com/science/article/pii/S0378427498002355

https://www.ncbi.nlm.nih.gov/pubmed/10022282


The photomutagenicity of fluoroquinolones in tests for gene mutation,  chromosomal aberration, gene conversion and DNA breakage (Comet assay)

https://fqresearch.org/pdf_files/The-photomutagenicity-of-fluoroquinolones-in-tests-for-gene-mutation-chromosomal-aberration-gene-conversion-and-DNA-breakage.pdf

https://academic.oup.com/mutage/article/11/5/497/1044656


Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

https://www.ncbi.nlm.nih.gov/pubmed/24410307


Pro-apoptotic effect of new quinolone 7- ethyl  9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate  on cervical cancer cell line HeLa alone/with UVA irradiation

https://www.sciencedirect.com/science/article/pii/S0887233316300285

https://www.ncbi.nlm.nih.gov/pubmed/26916084


Generalized Seizure and Toxic Epidermal Necrolysis Following Levofloxacin Exposure

https://www.researchgate.net/profile/Tabo_Sikaneta/publication/7910080_Generalized_Seizure_and_Toxic_Epidermal_Necrolysis_Following_Levofloxacin_Exposure/links/0c96053ac9095855c8000000/Generalized-Seizure-and-Toxic-Epidermal-Necrolysis-Following-Levofloxacin-Exposure.pdf

https://www.ncbi.nlm.nih.gov/pubmed/15827068


Fluoroquinolone Adverse Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691


New insights in extracellular matrix  remodeling and collagen turnover related pathways in cultured human  tenocytes after ciprofloxacin administration

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838320/ 


Changes in the Oxidation-Reduction State of Human Dermal Fibroblasts as an Effect of Lomefloxacin Phototoxic Action

https://pubmed.ncbi.nlm.nih.gov/35741100/



DETOX

Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26838075

DNA INTERACTION

A comparative analysis of chromosomal aberrations in cultured human  lymphocytes due to fluoroquinolone drugs at different expression periods

https://link.springer.com/article/10.1007/s00204-009-0509-9

https://www.ncbi.nlm.nih.gov/pubmed/20049419

  

Antibacterial and Anticancer Drugs - Interaction with DNA

http://dx.doi.org/10.1016/j.jinorgbio.2006.06.011


Interaction between ciprofloxacin and DNA mediated by Mg2+-ions

http://dx.doi.org/10.1016/S0020-1693(02)00933-7


Antibacterial Fluoroquinolone Agents - Interaction with DNA

http://dx.doi.org/10.1002/chem.200901158


Examining the Impact of Antimicrobial Fluoroquinolones on Human DNA Topoisomerase IIα and IIβ

https://pubs.acs.org/doi/10.1021/acsomega.8b03428  

  

Mechanisms of DNA damage, repair and mutagenesis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474181/


DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

https://www.sciencedirect.com/science/article/pii/S1074552110001614


Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes

https://www.science.org/doi/10.1126/sciadv.abe0384


DRUG INTERACTION

Analytical profile of the fluoroquinolone antibacterials I. Ofloxacin

https://www.ajol.info/index.php/ajb/article/view/58495/46839

https://www.researchgate.net/publication/27798177_Analytical_profile_of_the_fluoroquinolone_antibacterials_I_Ofloxacin


Fluoroquinolone-associated tendon-rupture: a summary of reports in  the Food and Drug Administration’s adverse event reporting system

https://www.ncbi.nlm.nih.gov/pubmed/26393387


Ciprofloxacin induced chondrotoxicity and tendinopathy

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.925.203&rep=rep1&type=pdf

https://www.researchgate.net/publication/286328188_Ciprofloxacin_induced_chondrotoxicity_and_tendinopathy


Determination of the effects of ciprofloxacin in prevention of  aminoglycoside induced nephrotoxicity in rabbits: A comparative study

https://www.researchgate.net/publication/286301571_Determination_of_the_effects_of_ciprofloxacin_in_prevention_of_aminoglcoside_induced_nephrotoxicity_in_rabbits


Effects of Fluoroquinolones and Glucocorticoids on Cultivated Tendon Cells In Vitro

https://www.ncbi.nlm.nih.gov/pubmed/20650258


Inhibitory effect of several fluoroquinolones on hepatic microsomal cytochrome P-450 1A activities in dogs

https://www.ncbi.nlm.nih.gov/pubmed/16343288


Effects of fluoroquinolones on CYP4501A and 3A in male broilers

https://www.ncbi.nlm.nih.gov/pubmed/20580800


Possible Intermolecular Interaction between Quinolones and Biphenylacetic Acid Inhibits y-Aminobutyric Acid Receptor Sites

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC284738/pdf/aac00374-0093.pdf

https://www.ncbi.nlm.nih.gov/pubmed/7840564


Fluoroquinolones Influence the intracellular calcium handling in individuals susceptible to malignant hyperthermia

http://onlinelibrary.wiley.com/doi/10.1002/mus.22021/full

https://www.ncbi.nlm.nih.gov/pubmed/21607983


Levofloxacin-induced Myasthenic Crisis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564188/


Levofloxacin-associated hypoglycaemia complicated by pontine myelinolysis and uadriplegia

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613252/pdf/dme0025-0856.pdf

https://www.ncbi.nlm.nih.gov/pubmed/18644072


Levofloxacin-induced Achilles tendon rupture in a patient with systemic microscopic plyangiitis

https://www.ncbi.nlm.nih.gov/pubmed/17029067

https://link.springer.com/article/10.1007/s10165-005-0393-y


Peripheral sensory disturbances related to treatment with fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/8722551

https://pdfs.semanticscholar.org/4668/37688f8d0aad9843083a10c3398c883e92a5.pdf


Potential Interactions of the Extended-Spectrum Fluoroquinolones with the CNS

https://link.springer.com/article/10.2165/00002018-199921020-00005

https://www.researchgate.net/publication/12844275_Potential_Interactions_of_the_Extended-Spectrum_Fluoroquinolones_with_the_CNS


Unexpected, severe central nerve system toxicity of ofloxacine: report of two cases

https://www.ncbi.nlm.nih.gov/pubmed/17268904


Risk of Severe Dysglycemia Among Diabetic Patients Receiving Levofloxacin, Ciprofloxacin, or Moxifloxacin in Taiwan

https://www.ncbi.nlm.nih.gov/pubmed/23948133


Safety issues and drug—drug interactions with commonly used quinolones

https://www.ncbi.nlm.nih.gov/pubmed/25423877

https://www.researchgate.net/publication/268816291_Safety_issues_and_drug-drug_interactions_with_commonly_used_quinolones


Synergistic effects of dexamethasone and quinolones on human-derived tendon cells

https://www.ncbi.nlm.nih.gov/pubmed/20034766

http://www.ijaaonline.com/article/S0924-8579(09)00483-X/fulltext

https://www.sciencedirect.com/science/article/abs/pii/S092485790900483X


The perils of prescribing fluoroquinolones http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true

https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf


The Safety Profile of the Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/10945507


Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

https://www.ncbi.nlm.nih.gov/pubmed/24410307

https://www.researchgate.net/publication/259696609_Third_and_Fourth_Generation_Fluoroquinolone_Antibacterials_A_Systematic_Review_of_Safety_and_Toxicity_Profiles


Convulsant and Subconvulsant Doses of Norfloxacin in the Presence and  Absence of Biphenylacetic Acid Alter Extracellular Hippocampal  Glutamate but Not Gamma-Aminobutyric Acid Levels in Conscious Rats

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127025/pdf/0301.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127025/

https://www.ncbi.nlm.nih.gov/pubmed/11796360


Enhanced susceptibility of pentylenetetrazole kindled mice to quinolone effects

https://www.ncbi.nlm.nih.gov/pubmed/10461842

https://www.sciencedirect.com/science/article/pii/S0924857999000679


Evaluation of the Possible Epileptogenic Activity of Ciprofloxacin: The Role of Nigella sativa on Amino Acids Neurotransmitters

https://www.ncbi.nlm.nih.gov/pubmed/23086472

https://www.semanticscholar.org/paper/Evaluation-of-the-Possible-Epileptogenic-Activity-Arafa-Abdel-Rahman/3f88780c483c681d76da75adcf7c3db171227a08


Hepatocytes-the choice to investigate drug metabolism and toxicity in man: In Vitro variability as a reflection of in vivo

https://www.ncbi.nlm.nih.gov/pubmed/17134688

https://www.researchgate.net/publication/6663416_Hepatocytes-the_choice_to_investigate_drug_metabolism_and_toxicity_in_man_In_vitro_variability_as_a_reflection_of_in_vivo


Hippocampal Activity in the Presence of Quinolones and fenbufen in-vitro

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC284301/pdf/aac00376-0152.pdf

https://www.ncbi.nlm.nih.gov/pubmed/1929256


Pharmacokinetic Pharmacokinetic drug‑drug interaction and their implication in clinical management

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897029/

https://www.ncbi.nlm.nih.gov/pubmed/24516494


Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes

https://www.nature.com/articles/aps2008184.pdf

https://www.ncbi.nlm.nih.gov/pubmed/19026171


Effect of fluoroquinolones for Anticonvulsant activities on PTZ induced seizures in mice

http://www.journalijar.com/uploads/2013-11-01_111226_981.pdf

http://www.journalijar.com/article/417/effect-of-fluoroquinolones-for-anticonvulsant-activities-on-ptz-induced-seizures-in-mice/


A pharmacokinetic-pharmacodynamic approach to show that not all  fluoroquinolones exhibit similar sensitivity toward the proconvulsant  effect of biphenyl acetic acid in rats

https://www.ncbi.nlm.nih.gov/pubmed/11733465

https://academic.oup.com/jac/article/48/6/813/743793


Adverse Reactions to Fluoroquinolones. An Overview on Mechanistic Aspects

https://www.researchgate.net/profile/Giovambattista_Sarro/publication/12157138_Adverse_Reactions_to_Fluoroquinolones_An_Overview_on_Mechanistic_Aspects/links/0fcfd50e06aba5f2b3000000.pdf

https://www.ncbi.nlm.nih.gov/pubmed/11172695


Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect – comprehensive overview of clinical trials

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785617/pdf/40360_2016_Article_53.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26960809


Effect of Bile Duct Ligation and Unilateral Nephrectomy on Brain  Concentration and Convulsant Potential of the Quinolone Antibacterial  Agent Levofloxacin in Rats

https://academic.oup.com/toxsci/article-pdf/29/2/280/4593964/29-2-280.pdf


Peripheral neuropathy and Guillain-Barré syndrome risks associated  with exposure to systemic fluoroquinolones: a pharmacovigilance analysis

https://www.ncbi.nlm.nih.gov/pubmed/24472364

https://www.sciencedirect.com/science/article/pii/S1047279713004754


Alteration of pharmacokinetics of cyclophosphamide and suppression of the cytochrome P450 genes by ciprofloxacin

https://www.nature.com/articles/1703815.pdf

https://www.ncbi.nlm.nih.gov/pubmed/12621481


Antimicrobial Safety: Focus on Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/15942881

https://academic.oup.com/cid/article/41/Supplement_2/S144/308000


Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26838075


Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human

https://www.ncbi.nlm.nih.gov/pubmed/8894516

https://www.ncbi.nlm.nih.gov/pubmed/26838075


The Quinolones, Ch 16, Prospects

https://www.sciencedirect.com/science/article/pii/B9780120595174500179


Fluoroquinolone Adverse Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691


Quinolone-induced Hypoglycemia: A Life-threatening but potentially reversible side effect

http://www.amjmed.com/article/S0002-9343(09)00871-7/pdf

https://www.amjmed.com/article/S0002-9343(09)00871-7/fulltext


Investigating effects of the antibiotic ciprofloxacin on the dopaminergic SH-SY5Y cell line

https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1275&context=masters_theses_2

http://scholarworks.umass.edu/masters_theses_2/2

DYSGLYCEMIA

FDA Warning and Study Highlight Fluoroquinolone Risks

https://jamanetwork.com/journals/jama/article-abstract/1737039?redirect=true

https://www.ncbi.nlm.nih.gov/pubmed/24026585


Possible involvement of DEC1 on the adverse effects of quinolone antibiotics

http://www.myquinstory.info/wp-content/uploads/2010/01/Shi-2010-DEC1.pdf

https://www.ncbi.nlm.nih.gov/pubmed/20214949


Comparative Risk of Serious Hypoglycemia among Persons Dispensed a Fluoroquinolone versus a Non-fluoroquinolone Antibiotic https://www.mdlinx.com/journal-summary/comparative-risk-of-serious-hypoglycemia-among-persons-dispensed-a-fluoroquinolone-vs-a-non/1vy8RCPhcgvuvcGY6WNWiK  

ENDOCRINE

Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell Death  Signaling and Reduces TNF Clearance in a Murine Model of Idiosyncratic  Hepatotoxicity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742585/pdf/kfp163.pdf

https://www.ncbi.nlm.nih.gov/pubmed/19638433


The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203117/pdf/pone.0025637.pdf

https://www.ncbi.nlm.nih.gov/pubmed/22046243


The effect of levofloxacin and moxifloxacin on cardiovascular functions of rats with streptozotocin-induced diabetes

https://www.ncbi.nlm.nih.gov/pubmed/22621918

https://journals.sagepub.com/doi/abs/10.1177/1479164112445755


The insulinotropic effect of fluoroquinolones hypoglycemia

https://www.ncbi.nlm.nih.gov/pubmed/19073153

https://www.sciencedirect.com/science/article/pii/S000629520800854X


Gatifloxacin Induces S and G2-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via p21/p27/p53

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047796

https://www.ncbi.nlm.nih.gov/pubmed/23133524

ENVIRONMENTAL CONTAMINATION

Metal-mediated oxidation of fluoroquinolone antibiotics in water:  Areview on kinetics, transformation products, and toxicity assessment

https://www.sciencedirect.com/science/article/pii/S0304389417306593

https://www.ncbi.nlm.nih.gov/pubmed/28919428


A one-step chemiluminescence immunoassay for 20 fluoroquinolone residues in fish and shrimp

based on a single chain Fv–alkaline phosphatase fusion protein

http://pubs.rsc.org/en/Content/ArticleLanding/2015/AY/c5ay01410g#!divAbstract

https://www.researchgate.net/publication/280974405_A_one-step_chemiluminescence_immunoassay_for_20_fluoroquinolone_residues_in_fish_and_shrimp_based_on_a_single_chain_Fv-alkaline_phosphatase_fusion_protein


Preparation and characterization of molecularly imprinted monolithic  column for on-line solid-phase extraction coupled with HPLC for  determination of the fluoroquinolone residues in honey samples

http://www.tandfonline.com/doi/abs/10.1080/10826076.2011.649877

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170576/


Acute toxicity evaluation for quinolone antibiotics and their chlorination disinfection processes

https://www.ncbi.nlm.nih.gov/pubmed/25193832

http://www.jesc.ac.cn/jesc_en/ch/reader/create_pdf.aspx?file_no=2014260910&year_id=2014&quarter_id=9&falg=1


Metal-mediated oxidation of fluoroquinolone antibiotics in water: A  review on kinetics, transformation products, and toxicity assessment

https://www.sciencedirect.com/science/article/pii/S0304389417306593

https://www.ncbi.nlm.nih.gov/pubmed/28919428


Analysis of positions and substituents on genotoxicity of  fluoroquinolones with quantitative structure-activity relationship and  3D Pharmacophore model

https://www.ncbi.nlm.nih.gov/pubmed/27835744

https://www.sciencedirect.com/science/article/pii/S0147651316304493


Antibiotics Threaten Wildlife: Circulating Quinolone Residues and Disease in Avian Scavengers

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186382/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001444


Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test

https://hal.archives-ouvertes.fr/hal-01191262/document

https://www.ncbi.nlm.nih.gov/pubmed/22047769


Chemiluminescence competitive indirect enzyme immunoassay for 20 fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/23842902

https://link.springer.com/article/10.1007%2Fs00216-013-7174-9


Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model  of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression  Profile and Interferon Gamma–Dependent Liver Injury

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638649/pdf/kfn205.pdf


Determination of fluoroquinolone antibiotic residues in the plasma of Eurasian griffon vultures (Gyps fulvus) in Spain

https://www.ncbi.nlm.nih.gov/pubmed/27037883

https://www.sciencedirect.com/science/article/pii/S004896971630506X


High-resolution mass spectrometry applied to the identification of  transformation products of quinolones from stability studies and new  metabolites of enrofloxacin in chicken muscle tissues

http://diposit.ub.edu/dspace/bitstream/2445/50423/1/633709.pdf


Levofloxacin residues in chicken meat and giblets

https://www.researchgate.net/publication/258990521_LEVOFLOXACIN_RESIDUES_IN_CHICKEN_MEAT_AND_GIBLETS


Oxidative transformation of levofloxacin by d-MnO2: Products, pathways and toxicity assessment

https://www.ncbi.nlm.nih.gov/pubmed/25036942

https://www.sciencedirect.com/science/article/pii/S004565351400811X?via%3Dihub


Electrochemical oxidation of fluoroquinolone antibiotics: Mechanism, residual antibacterial activity and toxicity change

https://www.researchgate.net/profile/Linyan_Zhu/publication/303883121_Electrochemical_oxidation_of_fluoroquinolone_antibiotics_Mechanism_residual_antibacterial_activity_and_toxicity_change/links/5a201928458515341c838d0d/Electrochemical-oxidation-of-fluoroquinolone-antibiotics-Mechanism-residual-antibacterial-activity-and-toxicity-change.pdf


Quinolone Antibiotics Induce Shiga Toxin–Encoding Bacteriophages, Toxin Production, and Death in Mice

https://www.ncbi.nlm.nih.gov/pubmed/10669353


Simultaneous Determination of the Residues of Fourteen Quinolones and  Fluoroquinolones in Fish Samples using Liquid Chromatography with  Photometric and Fluorescence Detection

http://www.agriculturejournals.cz/publicFiles/56594.pdf


Residue Depletion Study of Danofloxacin in Cultured Tilapia (Oreochromis mossambicus)

https://www.ncbi.nlm.nih.gov/pubmed/26025372


Screening of Antibiotic Residues in Poultry Liver, Kidney and Muscle in Khartoum State, Sudan

https://pdfs.semanticscholar.org/5640/556fcccf7260990ad15703928eab8db73058.pdf


Toxicological Assessment of Trace b-Diketone Antibiotic Mixtures on Zebrafish (Danio rerio) by Proteomic Analysis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111491/pdf/pone.0102731.pdf


Wildlife contamination with fluoroquinolones from livestock: Widespread occurrence of enrofloxacin and marbofloxacin in vultures

https://www.ncbi.nlm.nih.gov/pubmed/26498102


Increasing toxicity of enrofloxacin over four generations of Daphnia Magna

https://www.ncbi.nlm.nih.gov/pubmed/27379980


Pharmacokinetic and residue studies of quinolone compounds and olaquindox in poultry

https://hal.archives-ouvertes.fr/hal-00902002/document


Rapid Depletion of Marbofloxacin Residues in Rabbit after Therapeutic Treatment

http://jfoodprotection.org/doi/pdf/10.4315/0362-028X-68.11.2480


Effects and Interactions in an Environmentally Relevant Mixture of Pharmaceuticals

https://www.ncbi.nlm.nih.gov/pubmed/18048368


Fluoroquinolone resistance in the external environment and the human gut

https://www.researchgate.net/publication/268631267_Fluoroquinolone_resistance_in_the_environment_and_the_human_gut_-_Analysis_of_bacterial_DNA_sequences_to_explore_the_underlying_genetic_mechanisms


Comparison of plasma and tissue disposition of enrofloxacin in  rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio)  after a single oral Administration

https://www.ncbi.nlm.nih.gov/pubmed/25372241

http://www.academia.edu/29179296/Comparison_of_plasma_and_tissue_disposition_of_enrofloxacin_in_rainbow_trout_Oncorhynchus_mykiss_and_common_carp_Cyprinus_carpio_after_a_single_oral_administration


Concentrations of Antibiotic Residues Vary between Different Edible Muscle Tissues in Poultry

http://jfoodprotection.org/doi/pdf/10.4315/0362-028X-68.10.2217?code=fopr-site


Development of a Monoclonal Antibody-Based Broad-Specificity ELISA for Fluoroquinolone

Antibiotics in Foods and Molecular Modeling Studies of Cross-Reactive Compounds

https://www.ncbi.nlm.nih.gov/pubmed/17511422


Engineering of a broad-specificity antibody: Detection of eight fluoroquinolone antibiotics simultaneously

https://www.ncbi.nlm.nih.gov/pubmed/20920457


Concerns about extralabel fluoroquinolone use in food-producing animals

https://avmajournals.avma.org/doi/pdf/10.2460/javma.243.9.1242


  FQ and Metabolites in Chicken Muscles using MS-MS Barcelona Spain

http://diposit.ub.edu/dspace/bitstream/2445/50423/1/633709.pdf

FARMING / FOOD SUPPLY

Confirmation of fluoroquinolone residues in salmon

https://www.fda.gov/downloads/Food/FoodScienceResearch/ucm071507.pdf


FDA FQ residue

https://www.researchgate.net/publication/237526315_Confirmation_of_fluoroquinolone_residues_in_salmon_and_shrimp_tissue_by_LCMS_Evaluation_of_single_quadrupole_and_ion_trap_instruments


Levofloxacin residues in chicken meat and giblets

https://www.researchgate.net/publication/258990521_LEVOFLOXACIN_RESIDUES_IN_CHICKEN_MEAT_AND_GIBLETS

FLUOROQUINOLONES

Concurrent Determination of Four Fluoroquinolones; Ciprofloxacin, Enrofloxacin,

Sarafloxacin and Difloxacin in Atlantic Salmon Tissue by LC with Fluorescence Detection

https://www.ncbi.nlm.nih.gov/pubmed/12477191

https://www.researchgate.net/publication/10995544_Concurrent_Determination_of_Four_Fluoroquinolones_in_Catfish_Shrimp_and_Salmon_by_Liquid_Chromatography_with_Fluorescence_Detection


Screening of Antibiotic Residues in Poultry Liver, Kidney and Muscle in Khartoum State, Sudan

https://pdfs.semanticscholar.org/5640/556fcccf7260990ad15703928eab8db73058.pdf


An Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo

https://www.ncbi.nlm.nih.gov/pubmed/18829036


The Toxicologist ISSN 1096-6080 Volume 108, Number 1, March 2009 Supplement to Toxicological Sciences

https://www.toxicology.org/pubs/docs/Tox/2009Tox.pdf


FLUOROQUINOLONE ADR'S

Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model  of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression  Profile and Interferon Gamma–Dependent Liver Injury

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638649/pdf/kfn205.pdf

  

Treatment of the Fluoroquinolone Associated Disability –

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf

https://www.hindawi.com/journals/omcl/2017/8023935/


Fluoroquinolones-Associated Disability: It Is Not All in Your Head 

https://www.mdpi.com/2673-4087/2/3/17/htm


A New Criterion for Fluoroquinolone-Associated Disability Diagnosis: Functional Gastrointestinal Disorders  https://www.mdpi.com/1648-9144/57/12/1371 


Fluoroquinolone antibiotics and adverse events https://www.nps.org.au/australian-prescriber/articles/fluoroquinolone-antibiotics-and-adverse-events?fbclid=IwAR08oCisVnsxi28yEtqI93VFKplxmn9ujefwgufKaKjEt3IDTB8c7E9_VEs 

FLUOROQUINOLONE ANTIBODIES

Development of an immunoaffinity column method using  broad-specificity monoclonal antibodies for simultaneous extraction and  cleanup of quinolone and sulfonamide antibiotics in animal muscle  tissues

https://www.ncbi.nlm.nih.gov/pubmed/18823896


An Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo

https://mcb.asm.org/content/20/2/594

http://www.academia.edu/28240946/An_antitumor_drug-induced_topoisomerase_cleavage_complex_blocks_a_bacteriophage_T4_replication_fork_in_vivo

FLUOROQUINOLONE DEGRADATION

Evaluation and degradation Chemistry of Orbifloxacin using LC-MS

https://www.ijsciences.com/pub/article/257

FLUOROQUINOLONE ORGANIC COMPOUNDS

7-{4-[(1,3-Benzodioxol-5-yl) methyl]-piperazin-1-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394047/pdf/e-68-o2264.pdf


A Convergent Synthetic Route to (+)-Dynemicin A and Analogs of Wide Structural Variability

http://pubs.acs.org/doi/abs/10.1021/ja9703741


A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles

https://www.ncbi.nlm.nih.gov/pubmed/17458997

http://pubs.acs.org/doi/pdf/10.1021/jo070181o

GASTROINTESTINAL

Adverse Drug Reactions Related to the Use of Fluoroquinolone  Antimicrobials An Analysis of Spontaneous Reports and Fluoroquinolone  Consumption Data from Three Italian Regions

https://www.researchgate.net/profile/Roberto_Leone/publication/10945635_Adverse_drug_reactions_related_to_the_use_of_fluoroquinolone_antimicrobials_an_analysis_of_spontaneous_reports_and_fluoroquinolone_consumption_data_from_three_italian_regions/links/0912f50e538574cc25000000/Adverse-drug-reactions-related-to-the-use-of-fluoroquinolone-antimicrobials-an-analysis-of-spontaneous-reports-and-fluoroquinolone-consumption-data-from-three-italian-regions.pdf


Ciprofloxacin decreases survival in HT-29 cells via the induction of  TGF-b1 secretion and enhances the anti-proliferative effect of  5-fluorouracil

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707983/pdf/bph0157-0362.pdf


Safety issues and drug—drug interactions with commonly used quinolones

https://www.ncbi.nlm.nih.gov/pubmed/25423877

https://www.researchgate.net/publication/268816291_Safety_issues_and_drug-drug_interactions_with_commonly_used_quinolones


The perils of prescribing fluoroquinolones

http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true

https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf


Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

https://www.ncbi.nlm.nih.gov/pubmed/24410307


Mechanistic Study on Flumequine Hepatocarcinogenicity Focusing on DNA Damage in Mice

https://academic.oup.com/toxsci/article/69/2/317/1679679

https://www.ncbi.nlm.nih.gov/pubmed/12377980


The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203117/pdf/pone.0025637.pdf


Effect of Fluoroquinolone Treatment on Growth of and Toxin Production by Epidemic and Nonepidemic Clostridium difficile Strains in the Cecal Contents of Mice_

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1932513/pdf/1582-06.pdf


Fluoroquinolone Adverse Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691


A New Criterion for Fluoroquinolone-Associated Disability Diagnosis: Functional Gastrointestinal Disorders  https://www.mdpi.com/1648-9144/57/12/1371 

GENITOURINARY

Mechanistic Study on Flumequine Hepatocarcinogenicity Focusing on DNA Damage in Mice

https://academic.oup.com/toxsci/article/69/2/317/1679679

https://www.ncbi.nlm.nih.gov/pubmed/12377980

GENOTOXICITY

DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes

https://www.ncbi.nlm.nih.gov/pubmed/19122895


Topoisomerase II inhibition involves characteristic chromosomal expression patterns

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488358/pdf/1471-2164-9-324.pdf


Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro

http://www.nmcth.edu/images/gallery/Editorial/xRZVmps_ambulkar.pdf


4-Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes In Vitro

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf


A comparative analysis of chromosomal aberrations in cultured human  lymphocytes due to fluoroquinolone drugs at different expression periods

https://www.researchgate.net/publication/40848285_A_comparative_analysis_of_chromosomal_aberrations_in_cultured_human_lymphocytes_due_to_fluoroquinolone_drugs_at_different_expression_periods


Investigating effects of the antibiotic ciprofloxacin on the dopaminergic SH-SY5Y cell line

https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1275&context=masters_theses_2


Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells

https://www.ncbi.nlm.nih.gov/pubmed/26205818


Analysis of positions and substituents on genotoxicity of  fluoroquinolones with quantitative structure-activity relationship and  3D Pharmacophore model

https://www.ncbi.nlm.nih.gov/pubmed/27835744


Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment

of bacterial infections: a puzzling paradox or a logical consequence of their mode of action?

https://www.ncbi.nlm.nih.gov/pubmed/25515946


Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the

Vicia faba micronucleus test

https://hal.archives-ouvertes.fr/hal-01191262/document


Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors

https://www.ncbi.nlm.nih.gov/pubmed/9748648


Copper(II) complexes with norfloxacin and neutral terpyridines:  Cytotoxic, antibacterial, superoxide dismutase and DNA-interaction  approach

https://www.sciencedirect.com/science/article/pii/S0277538712002112


Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791872/pdf/bsr033e072.pdf


Ciprofloxacin: mammalian DNA topoisomerase type II poison in vivo

https://www.sciencedirect.com/science/article/pii/016579929390029U

https://www.ncbi.nlm.nih.gov/pubmed/7678175


Clinical toxicological aspects of fluoroquinolones

http://fqvictims.org/fqvictims/News/Clinical%20Toxicological%20Aspects%20of%20FQs/Clinical%20Toxicological%20Aspects%20of%20Fluroquinolones.pdf

https://www.ncbi.nlm.nih.gov/pubmed/12052667


Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells

https://www.ncbi.nlm.nih.gov/pubmed/23813946


Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in Ciprofloxacin-Treated Mammalian Cells

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.972.1373&rep=rep1&type=pdf

http://molpharm.aspetjournals.org/content/50/5/1178.long

https://www.ncbi.nlm.nih.gov/pubmed/8913349


Compare two methods of measuring DNA damage induced by photogenotoxicity of fluoroquinolones

http://www.chinaphar.com/article/view/7857/8443


DNA topoisomerases in mtDNA maintenance and ageing

https://www.ncbi.nlm.nih.gov/pubmed/24440386


Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase  IV by promoting the binding of Mg2+ to the second metal binding site

http://www.sciencedirect.com/science/article/pii/S030441651500358X

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720527/pdf/nihms749655.pdf


Genotoxic Evaluation of the Antibacterial Drug, Ciprofloxacin, in Cultured Lymphocytes of Patients with Urinary Tract Infection

http://journals.tubitak.gov.tr/medical/issues/sag-04-34-5/sag-34-5-4-0401-1.pdf


Genotoxic potential of quinolone antimicrobials in the in vitro comet assay and micronucleus test

https://www.ncbi.nlm.nih.gov/pubmed/16384725

https://www.sciencedirect.com/science/article/pii/S1383571805002846


Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective

https://www.ncbi.nlm.nih.gov/pubmed/18840496


In vitro induction of micronuclei and chromosome aberrations by quinolones: possible mechanisms

https://www.ncbi.nlm.nih.gov/pubmed/8676903


Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity

http://www.academia.edu/23099746/Investigations_into_the_concept_of_a_threshold_for_topoisomerase_inhibitor-induced_clastogenicity

https://www.ncbi.nlm.nih.gov/pubmed/12840108


Several gene programs are induced in ciprofloxacin-treated human lymphocytes as revealed by microarray analysis

https://www.ncbi.nlm.nih.gov/pubmed/12949250


DNA Gyrase and the supercoiling of DNA

https://www.ncbi.nlm.nih.gov/pubmed/6243420


DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC146802/pdf/252716.pdf


DNA Gyrase-mediated Wrapping of the DNA Strand Is Required for the  Replication Fork Arrest by the DNA Gyrase-Quinolone-DNA Ternary Complex

http://www.jbc.org/content/275/44/34780.full.pdf


DNA Strand Cleavage Is Required for Replication Fork Arrest by a Frozen Topoisomerase-Quinolone-DNA Ternary Complex

http://www.jbc.org/content/271/42/26424.full.pdf


DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

https://www.sciencedirect.com/science/article/pii/S1074552110001614?via%3Dihub


Study for genotoxicity and carcinogenicity of quinolone antimicrobials in mammals

https://www.researchgate.net/publication/247097248_Study_for_genotoxicity_and_carcinogenicity_of_quinolone_antimicrobials_in_mammals


Evaluating the genotoxicity of topoisomerase-targeted antibiotics

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331794/pdf/ger089.pdf


Evaluation of photodegradation, phototoxicity and photogenotoxicity of ofloxacin in ointments with sunscreens and in solutions

https://www.ncbi.nlm.nih.gov/pubmed/25728226

https://www.sciencedirect.com/science/article/pii/S101113441500041X


Inhibition of Human Topoisomerase II_ by Fluoroquinolones and Ultraviolet A Irradiation

https://academic.oup.com/toxsci/article/69/1/16/1707336


Relationship of cellular topoisomerase II a inhibition to  cytotoxicity and published genotoxicity of fluoroquinolone antibiotics  in V79 cells

https://www.sciencedirect.com/science/article/pii/S0009279713000057


Importance of the Fourth Alpha-Helix within the CAP Homology Domain  of Type II Topoisomerase for DNA Cleavage Site Recognition and Quinolone  Action

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127396/pdf/0027.pdf


Characterization of ciprofloxacin binding to the linear single- and double-stranded DNA

https://www.ncbi.nlm.nih.gov/pubmed/12890558


Chromosomal Aberrations and Genomic Instability Induced by Topoisomerase-Targeted Antitumour Drugs

https://www.ncbi.nlm.nih.gov/pubmed/15281904


Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.878.6133&rep=rep1&type=pdf


Inhibitory Effects of Quinolones on Pro- and Eucaryotic DNA Topoisomerases I and II

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC171971/pdf/aac00066-0125.pdf


Ofloxacin induces oxidative damage to joint chondrocytes of juvenile  rabbits: Excessive production of reactive oxygen species, lipid  peroxidation and DNA damage

https://www.ncbi.nlm.nih.gov/pubmed/19818344


Characterization of Abcc4 Gene Amplification in Stepwise-Selected  Mouse J774 Macrophages Resistant to the Topoisomerase II Inhibitor  Ciprofloxacin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230599/pdf/pone.0028368.pdf


Photogenotoxicity of Fluoroquinolones in Chinese Hamster V79 Cells: Dependency on Active Topoisomerase II

https://www.ncbi.nlm.nih.gov/pubmed/10089819

http://www.academia.edu/23364337/Photogenotoxicity_of_Fluoroquinolones_in_Chinese_Hamster_V79_Cells_Dependency_on_Active_Topoisomerase_II


Photosensitization Reactions of Fluoroquinolones and Their Biological Consequences

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.00978.x/full

https://www.ncbi.nlm.nih.gov/pubmed/21770950


Photosensitized DNA Damage; The Case of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/19320842

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2009.00548.x/abstract


Photosensitizing Mechanism and Identification of Levofloxacin Photoproducts at Ambient UV Radiation

https://www.ncbi.nlm.nih.gov/pubmed/22211524

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01068.x/abstract


Ciprofloxacin inhibits proliferation and promotes generation of aneuploidy in jurkat cells

http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf


Cytogenetic alterations in human lymphocyte cultures following exposure to ofloxacin

http://www.tandfonline.com/doi/full/10.1080/01480545.2016.1188305

https://www.ncbi.nlm.nih.gov/pubmed/27240646

 

Ofloxacin induces oxidative damage to joint chndrocytes of juvenile rabbits. Excessive

https://www.ncbi.nlm.nih.gov/pubmed/19818344


Inhibitory Effects of Quinolones on Pro- and Eucaryotic DNA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC171971/pdf/aac00066-0125.pdf


Chromosomal aberrations and genomic instability induced by topoisomerase-targeted antitumour drugs

https://pubmed.ncbi.nlm.nih.gov/15281904/


Characterization of ciprofloxacin binding to the linear

https://www.ncbi.nlm.nih.gov/pubmed/12890558


Importance of the Fourth Alpha-Helix within the CAP Homology

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127396/pdf/0027.pdf


Relationship of cellular topoisomerase II a inhibition to cytotoxicity

https://www.sciencedirect.com/science/article/pii/S0009279713000057


Inhibition of Human Topoisomerase II by Fluoroquinolones and Ultraviolet A Irradiation

https://academic.oup.com/toxsci/article/69/1/16/1707336


Evaluation of photodegradation, phototoxicity and photogenotoxicity

https://www.ncbi.nlm.nih.gov/pubmed/25728226

https://www.sciencedirect.com/science/article/pii/S101113441500041X


Evaluating the genotoxicity of topoisomerasetargeted

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331794/pdf/ger089.pdf


Several gene programs are induced in ciprofloxacin-treated

https://www.ncbi.nlm.nih.gov/pubmed/12949250


Investigations into the concept of a threshold for topoisomerase inhibitor‐induced clastogenicity

https://academic.oup.com/mutage/article/18/4/345/1079374


In Vitro induction of micronuclei and chromosome aberrations by quinolones possible

https://www.ncbi.nlm.nih.gov/pubmed/8676903


Genotoxicity of topoisomerase II inhibitors An anti-infective perspective

https://www.ncbi.nlm.nih.gov/pubmed/18840496


Genotoxic potential of quinolone antimicrobials in the in vitro comet assay and

https://www.ncbi.nlm.nih.gov/pubmed/16384725

https://www.sciencedirect.com/science/article/pii/S1383571805002846


Genotoxic Evaluation of the Antibacterial Drug

http://journals.tubitak.gov.tr/medical/issues/sag-04-34-5/sag-34-5-4-0401-1.pdf


Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase

http://www.sciencedirect.com/science/article/pii/S030441651500358X

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720527/pdf/nihms749655.pdf


DNA topoisomerases in mtDNA maintenance and ageing

https://www.ncbi.nlm.nih.gov/pubmed/24440386


DNA Damage from Phototoxicity of Quinolones

http://www.chinaphar.com/article/view/7857/8443


Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.972.1373&rep=rep1&type=pdf


Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.13364


Probabilistic Neural Network Multiple Classifier System for Predicting the Genotoxicity of Quinolone and Quinoline Derivatives

https://pubs.acs.org/doi/abs/10.1021/tx049742m?fbclid=IwAR2rFC3fqIj-pKURSSfQcJMTg40MNJBqMa6UIU8pd-fT9e2LNfBJP2HmzOw 


HEMATIC

Levofloxacin-Induced Autoimmune Hemolytic Anemia

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1004.1741&rep=rep1&type=pdf 

https://www.ncbi.nlm.nih.gov/pubmed/12841809


HEPATIC


2D, 3D-QSAR and molecular

https://www.ncbi.nlm.nih.gov/pubmed/24185373


Topoisomerase II inhibition involves characteristic chromosomal

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488358/pdf/1471-2164-9-324.pdf


Acute abdalla master

http://www.tandfonline.com/doi/abs/10.3109/15569543.2015.1076483?src=recsys&journalCode=itxr20

https://www.researchgate.net/publication/281174378_Acute_and_subacute_20-d_oral_dose_toxicity_study_of_modified_fluoroquinolone_compound_6C_in_BALBc_mice?el=1_x_2&enrichId=rgreq-e46136fb-bde7-4077-b86b-ca35779952d6&enrichSource=Y292ZXJQYWdlOzI4MTE3NDM3ODtBUzozNDI3MDQ3MDI2NzI4OTZAMTQ1ODcxODU3NjQ5OQ%3D%3D0029


Acyl Glucuronide DNA-adducts   from Quinolones

https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf


Adverse Effects

http://www.asmscience.org/content/book/10.1128/9781555817817.chap25


Fluoroquinolone Adverse  Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691


The Quinolones, Ch 16,   Prospects

https://www.sciencedirect.com/science/article/pii/B9780120595174500179


Safety of fluoroquinolones update

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/pdf/JID13054.pdf


Chronic administration of  caderofloxacin,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf


Antimicrobial Safety

https://watermark.silverchair.com/41-Supplement_2-S144.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAcAwggG8BgkqhkiG9w0BBwagggGtMIIBqQIBADCCAaIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMKoIvhZHNMfNCD9yVAgEQgIIBcyQ76rQdC7fqfJf-XagPVUhpjN4q2iJg8qIAwZtyqzjSq7nf5HnqomoYEQQOoCVD8n0nIEqIQ0er6gHUrGOt2bXVzKYRUph9O5QRBzeflGX_5q3leGHX8QzMXVHcd4QklfW66iydLGxp2qbqniMyJWxb0jcWnZpFf2ELrGX_Gqbn6Ng4t25uNkbXdoDh_cDvlhHhCAnLwLhjMFU2yNFpYxO7DQIbSpOAteO8YlB38EWxedMvfxC9MMpPYWm0tJUfERsabFwaLou5h1Brm9CrrTrBi4GYd4cvDZ9D31FTnaZ9bruQ0IDc60EhK68Ldb2yRBY7bcVVLAubK6MojxzgXpDuPrmHfojZEcvvxQYfgNgaZonH0M38cfb9Qd0j29-jco_rEUb9350UhSKhkVs-81htgmytFZ-B7OX53vUS22ulsguWWIofrYCH5AErH3UHp246yqud_jlSlQDfoKzuT8ayLcx-7D2b3K22zXwi-bv4NdF8


Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742585/pdf/kfp163.pdf


Comparison of plasma and tissue disposition of

https://www.ncbi.nlm.nih.gov/pubmed/25372241

http://www.academia.edu/29179296/Comparison_of_plasma_and_tissue_disposition_of_enrofloxacin_in_rainbow_trout_Oncorhynchus_mykiss_and_common_carp_Cyprinus_carpio_after_a_single_oral_administration


Ciprofloxacin-induced   cholestatic liver injury - a case report

http://vestnik.szd.si/index.php/ZdravVest/article/view/797/677


Drug bioactivation and protein   adduct formation in the pathogenesis of

https://www.researchgate.net/profile/Dominic_Williams2/publication/46287694_Drug_bioactivation_and_protein_adduct_formation_in_the_pathogenesis_of_drug-induced_toxicity/links/59e07a4ca6fdcca98431cbef/Drug-bioactivation-and-protein-adduct-formation-in-the-pathogenesis-of-drug-induced-toxicity.pdf


Hepatocytes-the choice to   investigate drug metabolism and toxicity in man 

https://www.ncbi.nlm.nih.gov/pubmed/17134688


Cytotoxic effects and   apoptosis induction of enrofloxacin in hepatic (1)

https://www.ncbi.nlm.nih.gov/pubmed/26475364


Trovafloxacin, a   fluoroquinolone antibiotic with hepatotoxic potential

https://www.ncbi.nlm.nih.gov/pubmed/20655887


Trovafloxacin-Induced Gene Expression Changes in Liver-Derived

http://dmd.aspetjournals.org/content/dmd/36/2/223.full.pdf


Trovafloxacin Enhances Lipopolysaccharide-Stimulated

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056269/pdf/jpet.114.214189.pdf


Toxicol.   Sci.-2002-Kashida-317-21

https://watermark.silverchair.com/121002000317.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAbEwggGtBgkqhkiG9w0BBwagggGeMIIBmgIBADCCAZMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMRSfF-Y2YLO4Omus7AgEQgIIBZLer0sQRIfsl7bmIMs4S_7TDjv8eBsrT3U9SMbqEmZlwDYA1vdZaQnHSIhZJeiuuGSsExih3FM_bNMvrgZ8QyslobNdBG2-GUSXUrKzoQ3PU_LcE0uq_GGfrswAXsNshdTpofeiGcNyFTJr-qKstsBXjGSjF60HJGBh9cfRI50I4ebUXGCXrO_DyPk1C0AnKqZyVHHzBWzju2irts72PjZgcoUl2l3M9GV6-_0fmZHFPeAoTfgO-bryD1tPuJev2004Rv2FCjRQQX8tKVHlQRrUfYr8rvpujmDVK6kwUoue34BRgi8RVlpYVBdswoZzlDv7BEbBUrfraLivRl8OCglmUfPmsN1KZPl39gYci5LvTZbNTlDR_lbdoySquD765yqXleNg3Ujji_MZ_507NR9j1juaNvhiersyfzBNvIxWLXE4nVzqJFjG7v7IL2Y4_8XbsYeFDdHTdxReFkip7jCk5IMy3


Third and Fourth Generation Fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/24410307


The Safety Profile of the Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/10945507


The perils of prescribing fluoroquinolones 

http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true


The inhibition of gluconeogenesis by gatifloxacin may contribute to its  hypoglycaemic action 

https://www.ncbi.nlm.nih.gov/pubmed/18706903

http://www.sciencedirect.com/science/article/pii/S0014299908008054?via%3Dihub


Study for genotoxicity and carcinogenicity of

https://docslide.com.br/documents/study-for-genotoxicity-and-carcinogenicity-of-quinolone-antimicrobials-in-mammals.html


Safety issues and drug—drug

https://www.ncbi.nlm.nih.gov/pubmed/25423877

https://www.researchgate.net/publication/268816291_Safety_issues_and_drug-drug_interactions_with_commonly_used_quinolones


Risk of hepatotoxicity associated with fluoroquinolones a national case-control

https://www.ncbi.nlm.nih.gov/pubmed/24352180

https://pdfs.semanticscholar.org/ad41/0ef510774fbf677a6f8c841716759452151a.pdf

http://digitalcommons.uri.edu/php_facpubs/28/


Risk of Acute Liver Injury Associated with the Use of Moxifloxacin and Other Oral Antimicrobials: A Retrospective, Population-Based Cohort Study 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260122/pdf/phar0034-0336.pdf


Mechanisms of trovafloxacin hepatotoxicity Studies

https://www.sciencedirect.com/science/article/pii/S0960894X07012498

https://www.ncbi.nlm.nih.gov/pubmed/17976985


Inhibitory effect of several fluoroquinolones on hepatic microsomal Cytochrome P-450 

https://www.ncbi.nlm.nih.gov/pubmed/16343288

  

Drug-induced liver injury: Interactions between drug properties and host factors

https://www.ncbi.nlm.nih.gov/pubmed/25912521


Fluoroquinolone therapy and idiosyncratic acute liver

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470619/pdf/1841565.pdf


Liver enzyme induction and inhibition: implications for anaesthesia

https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2044.2005.04462.x?fbclid=IwAR0b7i3hyVePWf6nv88h9c28l74BRDfbsxlGkceifCnJz13x7y65n5tP0BY

  


HEPATOXICITY

      

Unexpected severe hepatotoxicity of ciprofloxacine 

https://www.ncbi.nlm.nih.gov/pubmed/21314468

   

Risk of hepatotoxicity associated with fluoroquinolones: A national case–control safety study 

https://academic.oup.com/ajhp/article-abstract/71/1/37/5110881?redirectedFrom=fulltext


American Journal of Case Reports | A Case of Levofloxacin-Induced Hepatotoxicity

https://amjcaserep.com/abstract/metrics/idArt/907440 

HERG K+ Channell

   

Relationship of cellular topoisomerase II a inhibition to cytotoxicity

https://www.sciencedirect.com/science/article/pii/S0009279713000057    


HYPOGLYCEMIA

   

Metal-mediated oxidation of fluoroquinolone

https://www.sciencedirect.com/science/article/pii/S0304389417306593


Quinolone-induced Hypoglycemia: A Life-threatening but Potentially Reversible Side Effect

http://www.amjmed.com/article/S0002-9343(09)00871-7/pdf     


IMMUNE

  

4-Quinolone Drugs Affect Cell Cycle Progression and Function of

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf


Fluorinated 4-quinolones induce hyperproduction of interleukin 2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC287008/pdf/pnas00248-0298.pdf


Construction and sequencing analysis of scFv

https://www.researchgate.net/publication/315343941_Construction_and_sequencing_analysis_of_scFv_antibody_fragment_derived_from_monoclonal_antibody_against_norfloxacin_Nor155


Adverse Effects

http://www.asmscience.org/content/book/10.1128/9781555817817.chap25


Calcium Signals Are Affected by Ciprofloxacin as a Consequence

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/pdf/1543-05.pdf


Ciprofloxacin mammalian DNA topoisomerase type II poison in vivo

https://www.sciencedirect.com/science/article/pii/016579929390029U

https://www.ncbi.nlm.nih.gov/pubmed/7678175


Uptake and Intracellular Activity of Trovafloxacin in Human

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163701/pdf/410274.pdf


High-Performance Liquid Chromatography Measurement of

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC175825/pdf/aac00102-0064.pdf

  

Gatifloxacin Induces S and G2-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via p21/p27/p53

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047796


The Bile Acid Receptor GPBAR-1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203117/pdf/pone.0025637.pdf


Quinolone-Induced Upregulation of Osteopontin Gene Promoter

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370769/pdf/zac2868.pdf


Development of a Monoclonal Antibody-Based

https://www.ncbi.nlm.nih.gov/pubmed/17511422


Ciprofloxacin Induces an Immunomodulatory Stress

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC105711/pdf/ac001923.pdf


Treatment of the Fluoroquinolone Associated Disability –

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf

https://www.hindawi.com/journals/omcl/2017/8023935/


Hypersensitivity reactions to fluoroquinolones analysis of the factors

https://www.ncbi.nlm.nih.gov/pubmed/23600547


Fluoroquinolone toxicity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981197/pdf/cp-2012-4-e87.pdf


Immunomodulatory Activities of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/16518713

http://www.academia.edu/5656193/Immunomodulatory_Activities_of_Fluoroquinolones


Cytogenetic alterations in human lymphocyte

http://www.tandfonline.com/doi/full/10.1080/01480545.2016.1188305

https://www.ncbi.nlm.nih.gov/pubmed/27240646


CIPROFLOXACIN INHIBITS PROLIFERATION AND PROMOTES

http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf


Several gene programs are induced in ciprofloxacin-treated

https://www.ncbi.nlm.nih.gov/pubmed/12949250


Mitochondria Reactive Oxygen T-Cells by Cipro

http://www.jimmunol.org/content/jimmunol/184/9/4827.full.pdf


Genotoxic Evaluation of the Antibacterial Drug

http://journals.tubitak.gov.tr/medical/issues/sag-04-34-5/sag-34-5-4-0401-1.pdf


Hypersensitivity reactions to fluoroquinolones 

​https://link.springer.com/article/10.1007/s11882-005-0049-1

INTERACTION WITH OTHER PATHOGENS

  

FDA Warning and Study Highlight

https://jamanetwork.com/journals/jama/article-abstract/1737039?redirect=true


Quinolone-induced Hypoglycemia A

http://www.amjmed.com/article/S0002-9343(09)00871-7/pdf


Fluoroquinolone Adverse Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691


The Quinolones, Ch 16, Prospects

https://www.sciencedirect.com/science/article/pii/B9780120595174500179


The insulinotropic effect of fluoroquinolones hypoglycemia

https://www.ncbi.nlm.nih.gov/pubmed/19073153


The effect of levofloxacin and moxifloxacin on cardiovascular

https://www.ncbi.nlm.nih.gov/pubmed/22621918


The Effect of Ciprofloxacin Injection on Genetically Absence

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202555/pdf/BCN-4-031.pdf


Antibiotic-Induced Neurotoxicity

https://www.researchgate.net/profile/Shamik_Bhattacharyya/publication/267729744_Antibiotic-Induced_Neurotoxicity/links/54cb1bf40cf22f98631e0b1d.pdf


Third and Fourth Generation Fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/24410307


The perils of prescribing fluoroquinolones 

http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true

https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf


Torsades de pointes fq

http://onlinelibrary.wiley.com/doi/10.1016/j.clpt.2003.11.376/abstract;jsessionid=489433439AB92E1E398D07445C01B2BD.f04t02

https://www.ncbi.nlm.nih.gov/pubmed/15001976


Risk of Severe Dysglycemia Among Diabetic

https://www.ncbi.nlm.nih.gov/pubmed/23948133


Prulifloxacin as a trigger of myasthenia gravis

https://fqresearch.org/pdf_files/Prulifloxacin_trigger_myasthenia_gravis.pdf


Outpatient Gatifloxacin Therapy

https://www.researchgate.net/profile/Linda_Dresser/publication/7266633_Outpatient_Gatifloxacin_Therapy_and_Dysglycemia_in_Older_Adults/links/0f31753b3f06b5f6f4000000/Outpatient-Gatifloxacin-Therapy-and-Dysglycemia-in-Older-Adults.pdf


Levofloxacin-induced myasthenic crisis 

http://www.jem-journal.com/article/S0736-4679(12)01199-7/abstract

https://www.ncbi.nlm.nih.gov/pubmed/23218195 


Levofloxacin-induced crystal nephropathy 

http://onlinelibrary.wiley.com/doi/10.1111/nep.12405/abstract

https://www.ncbi.nlm.nih.gov/pubmed/25900386


Levofloxacin-induced Achilles tendon rupture in a patient with systemic microscopic polyangiitis 

 https://www.ncbi.nlm.nih.gov/pubmed/17029067

https://link.springer.com/article/10.1007/s10165-005-0393-y


Levofloxacin-associated hypoglycaemia complicated by

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613252/pdf/dme0025-0856.pdf


Fluoroquinolones influence the intracellular calcium handling in individuals 

http://onlinelibrary.wiley.com/doi/10.1002/mus.22021/full


Evaluation of the appropriate use of commonly prescribed fluoroquinolones and the

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410896/pdf/tcrm-11-639.pdf


Effect of fluoroquinolones on mitochondrial function in pancreatic beta

https://www.ncbi.nlm.nih.gov/pubmed/24284031

http://www.sciencedirect.com/science/article/pii/S0928098713004508?via%3Dihub

  

Fluoroquinolone-associated myasthenia gravis exacerbation: evaluation of postmarketing reports from the US FDA adverse event reporting system and a literature review 

https://www.ncbi.nlm.nih.gov/pubmed/21879778

https://link.springer.com/article/10.2165/11593110-000000000-00000

IRON CHELATION


Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf

JOINTS

Pharmacokinetic Prediction of Levofloxacin Accumulation

https://www.researchgate.net/publication/261759355_Pharmacokinetic_prediction_of_levofloxacin_accumulation_in_tissue_and_its_association_to_tendinopathy

KIDNEY DAMAGE

Ciporofloxocin cryslluina

https://academic.oup.com/ndt/article/21/10/2982/1865584

LIMPHOCYTE

Pharmacokinetic Prediction of Levofloxacin Accumulation

https://www.researchgate.net/publication/261759355_Pharmacokinetic_prediction_of_levofloxacin_accumulation_in_tissue_and_its_association_to_tendinopathy

MAGNESIUM

Comparative Evaluation of Cartilage

https://www.ncbi.nlm.nih.gov/pubmed/8923679


In Vitro Evidence for Effects of Magnesium Supplementation 

https://www.ncbi.nlm.nih.gov/pubmed/11280370

MECHANISM OF BINDING

 Copper(I) complexes with phosphine derived from sparfloxacin

https://pdfs.semanticscholar.org/6a63/20aca61f78c3fd30b16435e535ed44707560.pdf 

http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract

METABOLIZATION

ACYL GLUCURONIDATION OF FLUOROQUINOLONE ANTIBIOTICS BY THE UDP-GLUCURONOSYLTRANSFERASE 1A SUBFAMILY IN HUMAN LIVER MICROSOMES

https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf


HIGH-RESOLUTION MASS SPECTROMETRY APPLIED TO THE IDENTIFICATION OF TRANSFORMATION PRODUCTS OF QUINOLONES

http://diposit.ub.edu/dspace/bitstream/2445/50423/1/633709.pdf


Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf

METAL COMPLEX

DNA interaction, in vitro antimicrobial and SOD-like activity of copper(II)

https://www.sciencedirect.com/science/article/pii/S0022328X11007388


Biological activities of some Fluoroquinolones-metal complexes 

https://scholar.google.com/scholar?q=Biological+activities+of+some+Fluoroquinolones-metal+complexes&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ved=0ahUKEwig4_Tyk_HYAhWkm-AKHTROAsQQgQMIJzAA

https://www.ajol.info/index.php/ijmbr/article/view/91824


Tandem mass spectrometric study of ciprofloxacin–polyethylene glycol

https://www.sciencedirect.com/science/article/pii/S1387380608002108


Copper(II) complexes with norfloxacin and neutral terpyridines: Cytotoxic, antibacterial, superoxide dismutase and DNA-interaction approach

https://www.sciencedirect.com/science/article/pii/S0277538712002112

https://www.ncbi.nlm.nih.gov/pubmed/25902267

https://www.researchgate.net/publication/275361582_Ciprofloxacin-induced_neurotoxicity_Evaluation_of_possible_underlying_mechanisms

MISCELLANEOUS

Amsacrine-promoted DNA cleavage site determinants

https://www.sciencedirect.com/science/article/pii/S0006295296005163


Oxidative degradation study on antimicrobial agent ciprofloxacin

https://www.ncbi.nlm.nih.gov/pubmed/25201488

https://www.sciencedirect.com/science/article/pii/S0045653514009874


Metabolism of-1,4-Dihydro-7trans3methoxy4methylamino

http://dmd.aspetjournals.org/content/37/3/594.long

http://dmd.aspetjournals.org/content/dmd/37/3/594.full.pdf


Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection

https://academic.oup.com/jac/article/51/5/1109/784308

https://www.ncbi.nlm.nih.gov/pubmed/12697644


Engineering of a broad-specificity antibody

https://www.ncbi.nlm.nih.gov/pubmed/20920457


Drug-drug interactions and QT prolongation as

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785617/pdf/40360_2016_Article_53.pdf

 
Breakage-Reunion Domain of Streptococcus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810434/pdf/pone.0000301.pdf


ZATT (ZNF451)–mediated resolution

https://www.ncbi.nlm.nih.gov/pubmed/28912134


The Effects of Levofloxacin on Testis Tissue 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819380/pdf/Cell-J-18-112.pdf


Effect of metal ions on some pharmacologically relevant interactions involving fluoroquinolones

https://www.researchgate.net/profile/Neelam_Seedher/publication/50591479_Effect_of_metal_ions_on_some_pharmacologically_relevant_interactions_involving_fl_uoroquinolone_antibiotics/links/57f4ce4808ae8da3ce54ea48/Effect-of-metal-ions-on-some-pharmacologically-relevant-interactions-involving-fl-uoroquinolone-antibiotics.pdf


The Structure of DNA-Bound Human Topoisomerase II Alpha:Conformational Mechanisms for Coordinating Inter-SubunitInteractions with DNA Cleavage

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584591/pdf/nihms397579.pdf


Quinolone Antibiotics Induce Shiga Toxin

https://www.ncbi.nlm.nih.gov/pubmed/10669353

https://academic.oup.com/jid/article/181/2/664/824154


The Effect of Some Fluoroquinolone Family Members

https://pdfs.semanticscholar.org/2439/2c5c31fdfcf55478b7c6e62234e1fed0560b.pdf


Mass spectrometic study of speciation in aluminium-fluoroquinolone solutions 

https://www.ncbi.nlm.nih.gov/pubmed/22837440

http://journals.sagepub.com/doi/abs/10.1255/ejms.1183?journalCode=emsa


Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes

https://europepmc.org/article/PMC/PMC7929499


Do Fluoroquinolones Increase Risk for Pseudotumor Cerebri?

https://www.jwatch.org/na44786/2017/08/21/do-fluoroquinolones-increase-risk-pseudotumor-cerebri?fbclid=IwAR3JbrnQgzi4VyuO9mfAG-y03zQT3Zq0ZJSfWOut4vxaa8EinQDCoI0zpLA


Association of Fluoroquinolone Prescribing Rates With Black Box Warnings from the US Food and Drug Administration https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786698?fbclid=IwAR1RWN9Gv1MXV_SL1N9FOXnTzxNOpW8Kcu-jMDlJNPYsxulApu_YShPQ1bM 


Transferable mechanisms of quinolone resistance https://www.academia.edu/12425533/Transferable_mechanisms_of_quinolone_resistance?email_work_card=title 


Ciprofloxacin and Levofloxacin as Potential Drugs in Genitourinary Cancer Treatment-The Effect of Dose-Response on 2D and 3D Cell Cultures https://www.docwirenews.com/gu-oncology-now/ciprofloxacin-and-levofloxacin-as-potential-drugs-in-genitourinary-cancer-treatment-the-effect-of-dose-response-on-2d-and-3d-cell-cultures/  


Fluoroquinolones are a potent form of chemotherapy https://onlinelibrary.wiley.com/doi/abs/10.1111/cxo.13102 

  

Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review

https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0216029&fbclid=IwAR2ZdKap19ZFIAGwd7bekbBsP_aVMOrimBeT0BnOZMzXvt4QQYlybphOwRg


The Use of Systemic Fluoroquinolones Committee on Infectious Diseases

https://www.academia.edu/30456990/The_Use_of_Systemic_Fluoroquinolones_Committee_on_Infectious_Diseases


Top2a promotes the development of social behavior via PRC2 and H3K27me3

https://pubmed.ncbi.nlm.nih.gov/36417527 



MITOCHONDRIA

2D, 3D-QSAR and molecular docking of 4(1H)-quinolones analogues with antimalarial activities 

https://www.ncbi.nlm.nih.gov/pubmed/24185373


4-Quinolones Cause a Selective Loss of Mitochondria

https://www.ncbi.nlm.nih.gov/pubmed/8440750


Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes In Vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf


Effects of Topoisomerase II-Active Drugs in Mitochondria

http://grantome.com/grant/NIH/R01-GM047535-01A1


Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences 

https://www.ncbi.nlm.nih.gov/pubmed/27771494

INVESTIGATING EFFECTS OF THE ANTIBIOTIC CIPROFLOXACIN ON THE DOPAMINERGIC SH-SY5Y CELL LINE

http://scholarworks.umass.edu/masters_theses_2/275/


2015 Effect of norfloxacin and moxifloxacin on melanin synthesis and 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf


Adverse Effects of Antimicrobials via Predictable or Idiosyncratic effects

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421593/pdf/zac4046.pdf


Calcium Signals Are Affected by Ciprofloxacin as a Consequence

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/pdf/1543-05.pdf


Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections

https://www.ncbi.nlm.nih.gov/pubmed/25515946


Bactericidal Antibiotics Induce Mitochondrial Dysfunction

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/pdf/nihms-509241.pdf


Butachlor induced dissipation of mitochondrial membrane potential

https://www.ncbi.nlm.nih.gov/pubmed/22884430

http://fac.ksu.edu.sa/sites/default/files/butachlor_induced_dissipation_of_mitochondrial_membrane_potential.pdf


Boar spermatozoa successfully predict mitochondrial modes of toxicity

https://www.ncbi.nlm.nih.gov/pubmed/25624015


Comparative Evaluation of Cartilage

https://www.ncbi.nlm.nih.gov/pubmed/8923679


Quinolones Action and Resistance Updated

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182077/pdf/CTMC-9-981.pdf


Pro-apoptotic effect of new quinolone

https://www.sciencedirect.com/science/article/pii/S0887233316300285

https://www.ncbi.nlm.nih.gov/pubmed/26916084


Interaction between quinolones antibiotics and bacterial outer membrane porin OmpF

https://www.ncbi.nlm.nih.gov/pubmed/15617818


Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

http://www.sciencedirect.com/science/article/pii/S0301008215300605?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/26603930?dopt=AbstractPlus


Treatment of the Fluoroquinolone Associated Disability 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf

https://www.hindawi.com/journals/omcl/2017/8023935/


Copper complexes with phosphine derived

http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract


Cytotoxic effects and apoptosis induction of enrofloxacin in hepatic 

https://www.ncbi.nlm.nih.gov/pubmed/26475364


Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential

https://www.ncbi.nlm.nih.gov/pubmed/20655887


Trovafloxacin-Induced Gene Expression Changes in Liver-Derived

http://dmd.aspetjournals.org/content/dmd/36/2/223.full.pdf


The Role of Mitochondria in Brain Aging and the Effects of Melatonin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001212/pdf/CN-8-182.pdf


The perils of prescribing fluoroquinolones 

http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true

https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf


The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglycaemic action

https://www.ncbi.nlm.nih.gov/pubmed/18706903

http://www.sciencedirect.com/science/article/pii/S0014299908008054?via%3Dihub


The effect of ciprofloxacin on sperm DNA damage, fertility potential and early embryonic development in NMRI mice

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312808/pdf/vrf-3-131.pdf


Quinolone-induced arthropathy an update focusing on new mechanistic and clinical data

https://www.ncbi.nlm.nih.gov/pubmed/18835137

https://www.sciencedirect.com/science/article/pii/S0924857908003531


CIPROFLOXACIN INHIBITS PROLIFERATION AND PROMOTES GENERATION OF ANEUPLOIDY IN JURKAT CELLS

http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf


Photosensitizing Mechanism and Identification of Levofloxacin Photoproducts at Ambient UV Radiation

https://www.ncbi.nlm.nih.gov/pubmed/22211524

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01068.x/abstract


Photosensitization Reactions of Fluoroquinolones and Their Biological Consequences

http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.00978.x/full

https://www.ncbi.nlm.nih.gov/pubmed/21770950


Ofloxacin induces oxidative damage to joint chondrocytes of juvenile rabbits

https://www.ncbi.nlm.nih.gov/pubmed/19818344


Ofloxacin induces apoptosis in microencapsulated juvenile rabbit

https://www.ncbi.nlm.nih.gov/pubmed/17961619


Musculoskeletal Complications of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/21333952


Lysosomal Membrane Permeabilization Induces Cell Death

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193790/pdf/20021952.pdf


Fluoroquinolones influence the intracellular calcium handling in individuals 

http://onlinelibrary.wiley.com/doi/10.1002/mus.22021/full


In vitro study of cytotoxicity of quinolones on rabbit tenocytes 

https://link.springer.com/article/10.1023/A:1007435025616


Fluoroquinolone Induced Tendinopathy

https://www.jstage.jst.go.jp/article/tjem/226/4/226_4_251/_pdf


Features of the ultrastructure of loach embryos under the influence of norfloxacin 

https://link.springer.com/article/10.1007/s11956-008-2005-1


Evaluation of gatifloxacin for eye

https://www.ncbi.nlm.nih.gov/pubmed/25028261

http://journals.sagepub.com/doi/abs/10.1177/0960327114530743


Fluoroquinolone-induced serious, persistent, multisymptom adverse effects

http://www.dougbremner.com/FQ_Golomb.pdf


Effect of norfloxacin and moxifloxacin on melanin synthesis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf


Effect of fluoroquinolones on mitochondrial function in pancreatic beta

https://www.ncbi.nlm.nih.gov/pubmed/24284031

http://www.sciencedirect.com/science/article/pii/S0928098713004508?via%3Dihub


Drug induced liver injury Interactions between drug properties

https://www.ncbi.nlm.nih.gov/pubmed/25912521


Role of Mitochondria in Ciprofloxacin Sperm Cells

http://eprints.umsu.ac.ir/786/1/1933719113477482.pdf


The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells

https://www.ncbi.nlm.nih.gov/pubmed/19235604


Mitochondria Reactive Oxygen T-Cells by Cipro

http://www.jimmunol.org/content/jimmunol/184/9/4827.full.pdf


Influence on Mitochondria and Cytotoxicity of Different Antibiotics 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797653/pdf/0729-05.pdf


In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon

http://jpet.aspetjournals.org/content/jpet/308/1/394.full.pdf


High-Content Screening for Compounds That Affect mtDNA-Encoded Protein 

https://www.ncbi.nlm.nih.gov/pubmed/20625181


Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective

https://www.ncbi.nlm.nih.gov/pubmed/18840496


Gene expression profiles in the articular cartilage of juvenile rats receiving the 

https://www.ncbi.nlm.nih.gov/pubmed/18572299


Fluoroquinolone-related neuropsychiatric

https://www.ncbi.nlm.nih.gov/pubmed/26955658


Effect of levofloxacin on glycosaminoglycan and DNA synthesis of cultured rabbit 

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.845.2627&rep=rep1&type=pdf


Effect of ciprofloxacin and levofloxacin on some oxidative stress parameters in brain regions of male albino rats

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.893.9513&rep=rep1&type=pdf


DNA topoisomerases in mtDNA maintenance and ageing

https://www.ncbi.nlm.nih.gov/pubmed/24440386


Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in Ciprofloxacin-treated Mammilian Cells

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.972.1373&rep=rep1&type=pdf


Damage to mitochondrial DNA induced by the quinolone Bay y 3118 in embryonic turkey liver

https://www.ncbi.nlm.nih.gov/pubmed/10216214


Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones

https://www.sciencedirect.com/science/article/pii/S1011134400001019

https://docslide.com.br/documents/damage-to-mitochondria-of-cultured-human-skin-fibroblasts-photosensitized-by.html

MITOCHONDRIAL DAMAGE CONSEQUENCES


A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes

http://www.cell.com/cancer-cell/pdf/S1535-6108(06)00372-2.pdf


Acute metabolic amplification of insulin secretion in mouse islets is mediated by 

https://www.ncbi.nlm.nih.gov/pubmed/23790612

https://www.sciencedirect.com/science/article/pii/S0026049513001479


Alternative Mitochondrial Electron Transfer for the Treatment of Neurodegenerative Diseases

https://www.ncbi.nlm.nih.gov/pubmed/26603930


Automated Spectrophotometric Analysis of Mitochondrial Respiratory Chain Complex 

http://clinchem.aaccjnls.org/content/clinchem/51/11/2110.full.pdf


Avermectin Confers Its Cytotoxic Effects by Inducing DNA Damage

https://www.ncbi.nlm.nih.gov/pubmed/27551889


Causes of Death in Adults with Mitochondrial Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864865/pdf/978-3-662-49833-0_Chapter_449.pdf


Chronic fatigue syndrome and mitochondrial dysfunction

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/pdf/ijcem0001-0001.pdf


Ciprofloxacin-induced cholestatic liver injury - a case report

http://vestnik.szd.si/index.php/ZdravVest/article/view/797/677


The Maintenance of Mitochondrial DNA Integrity—Critical Analysis and Update

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632056/pdf/cshperspect-DAM-a012641.pdf


DNA topoisomerases in mtDNA maintenance and ageing

https://www.ncbi.nlm.nih.gov/pubmed/24440386

https://www.sciencedirect.com/science/article/pii/S0531556514000126?via%3Dihub


Medication induced mitochondrial damage and disease

https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.200700075


Fluoroquinolone-related neuropsychiatric and mitochondrial toxicity: a collaborative

https://www.ncbi.nlm.nih.gov/pubmed/26955658

https://www.researchgate.net/publication/297893187_Fluoroquinolone-related_neuropsychiatric_and_mitochondrial_toxicity_A_collaborative_investigation_by_scientists_and_members_of_a_social_network.


Hypoxic Pulmonary Vasoconstriction From Molecular Mechanisms to Medicine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310129/pdf/main.pdf


In Vivo Inhibition of Trypanosome Mitochondrial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC359115/pdf/molcellb00009-0287.pdf


Increased prevalence of malignancy in adult mitochondrial disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034300/pdf/JMedLife-06-477.pdf


Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis

https://www.sciencedirect.com/science/article/pii/S016801021102061X


Methods to Study Mitochondrial Structure & Function

https://link.springer.com/chapter/10.1007/978-1-4614-4599-9_2


Mitochondrial abnormalities A link to idiosyncratic drug hepatotoxicity

https://www.ncbi.nlm.nih.gov/pubmed/17275868


Mitochondrial Disorders - Medicines to Avoid

http://www.medsafe.govt.nz/profs/PUArticles/June2017/MitochondrialDisordersMedicinestoAvoid.htm


Mitochondrial DNA Damage and its Consequences for Mitochondrial Gene Expression

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412069/pdf/nihms388439.pdf


Mitochondrial DNA damage induced autophagy, cell death

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750375/pdf/nihms756435.pdf


Mitochondrial DNA damage

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818501/pdf/12933_2016_Article_372.pdf


Mitochondrial DNA exhibits resistance to induced 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062989/pdf/gkw716.pdf


MITOCHONDRIAL DNA HAPLOGROUP-DEPENDENCE OF DRUGS AND XENOBIOTICS TOXICITY 

http://paduaresearch.cab.unipd.it/6619/1/Tesi_dottorato_Daniela_Strobbe.pdf


Mitochondrial Dysfunction and Chronic Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566449/pdf/35-43.pdf


Mitochondrial dysfunction and oxidative stress in aging and cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216692/pdf/oncotarget-07-44879.pdf


Mitochondrial dysfunction in aging Much progress but many

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580208/pdf/main.pdf


Mitochondrial dysfunction in cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844930/pdf/fonc-03-00292.pdf


Mitochondrial Dysfunction in Chemotherapy-Induced

http://www.mdpi.com/2305-6304/3/2/198/htm


Mitochondrial Reactive Oxygen Species Control T Cell Activation by Regulating IL-2 and IL-4 Expression Mechanism of Ciprofloxacin-Mediated Immunosuppression 

http://www.jimmunol.org/content/jimmunol/184/9/4827.full.pdf


MITOCHONDRIAL TESTS

http://www.dr-forsyth.com/Dr_Charles_Forsyth/Downloads_files/MITOCHONDRIAL%20TESTS.pdf


Mitochondrial DNA Rearrangements in Health and Disease—A Comprehensive Study

https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.22452


The In Depth Evaluation of Suspected Mitochondrial Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810849/pdf/nihms49523.pdf


Analysis of mitochondrial dynamics and functions using imaging approaches

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007120/pdf/nihms234287.pdf


Nonalcoholic fatty liver disease and mitochondrial dysfunction

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675113/pdf/WJG-14-193.pdf


Non-alcoholic fatty liver disease. From insulin resistance to mitochondrial dysfunction

http://www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=458456&TO=RVN&Eng=0


Oxidatative stress-induced mitochondrial dysfunction drives inflammation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559140/?report=printable


Patterns of Mitochondrial DNA Damage in Blood

https://www.karger.com/Article/FullText/339207


Problems in Mitochondrial DNA forensics 

http://www.tandfonline.com/doi/abs/10.1080/24701394.2017.1310853?journalCode=imdn21


Psychiatric symptoms of patients with primary mitochondrial DNA disorders

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348039/pdf/1744-9081-8-9.pdf


Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War illness

http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184832&type=printable


THE EFFECT OF BACTERIAL DNA GYRASE INHIBITORS ON DNA SYNTHESIS IN MAMMILIAN MITOCHONDRIA

http://www.myquinstory.info/wp-content/uploads/2010/01/Castora-DNA-Synthesis-In-mam-mtDNA-1983.pdf 


The other, forgotten genome: mitochondrial DNA and mental disorders

https://www.ncbi.nlm.nih.gov/pubmed/11673790


The Psychiatric Presentation of Mitochondrial Disorders in Adults

https://neuro.psychiatryonline.org/doi/pdf/10.1176/appi.neuropsych.11110345


The Role of Mitochondria in Brain Aging and the Effects of Melatonin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001212/pdf/CN-8-182.pdf


The Maintenance of Mitochondrial DNA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632056/pdf/cshperspect-DAM-a012641.pdf 


Effects of fluoroquinolones and tetracyclines on mitochondria of human retinal MIO-M1 cells https://www.sciencedirect.com/science/article/pii/S0014483521004231 

MITOCHONDRIAL TOXICITY

Fluoroquinolone antibiotics and possible mitochondrial toxicity

https://www.sciencedirect.com/science/article/pii/S1567724915001506?via%3Dihub

https://www.researchgate.net/publication/283164012_Fluoroquinolone_antibiotics_and_possible_mitochondrial_toxicity


Pathogenesis of quinolone-induced arthropathy: a review of hypotheses

https://www.ncbi.nlm.nih.gov/pubmed/15633793


Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010342/pdf/aps2011158a.pdf


Moxifloxacin and ciprofloxacin inducesS-phase arrest and augments apoptoticeffects of cisplatin in human pancreaticcancer cells via ERK activation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531397/pdf/12885_2015_Article_1560.pdf


Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf


Trimethoxy-benzaldehyde levofloxacin hydrazoneinducing the growth arrest and apoptosis ofhuman hepatocarcinoma cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716872/pdf/1475-2867-13-67.pdf

MOLECULAR STRUCTURE

Discovery of Fluoroquinolone derivatives as potent, selective inhibitors of PI3Kγ

http://pubs.rsc.org/en/content/articlelanding/md/2015/c5md00364d#!divAbstract

https://www.researchgate.net/publication/282525805_Discovery_of_Fluoroquinolone_derivatives_as_potent_selective_inhibitors_of_PI3Kg


Copper(I) complexes with phosphine derived

https://pdfs.semanticscholar.org/6a63/20aca61f78c3fd30b16435e535ed44707560.pdf 

http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract

MUSCLE

Fluoroquinolones and Musculoskeletal Toxicity In Pediatrics

http://sites.utexas.edu/pharmacotherapy-rounds/files/2015/09/kuriakose11-21-14.pdf


Pharmacokinetic Prediction of Levofloxacin Accumulation

https://www.researchgate.net/publication/261759355_Pharmacokinetic_prediction_of_levofloxacin_accumulation_in_tissue_and_its_association_to_tendinopathy

MUSCULOSKELETAL


Preclinical safety evaluation of moxifloxacin

https://academic.oup.com/jac/article/43/suppl_2/91/2473568


Adverse Drug Reactions Related to the Use of Fluoroquinolones

https://www.researchgate.net/profile/Roberto_Leone/publication/10945635_Adverse_drug_reactions_related_to_the_use_of_fluoroquinolone_antimicrobials_an_analysis_of_spontaneous_reports_and_fluoroquinolone_consumption_data_from_three_italian_regions/links/0912f50e538574cc25000000/Adverse-drug-reactions-related-to-the-use-of-fluoroquinolone-antimicrobials-an-analysis-of-spontaneous-reports-and-fluoroquinolone-consumption-data-from-three-italian-regions.pdf


Adverse Effects of Antimicrobials via Predictable or Idiosyncratic effects

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421593/pdf/zac4046.pdf


Effects of Difloxacin on the Metabolism of

https://www.sciencedirect.com/science/article/pii/S0272059083710341


Assessment of Musculoskeletal Toxicity 5 Years After

http://pediatrics.aappublications.org/content/pediatrics/134/1/e146.full.pdf


Fluoroquinolone Tendon Rupture Summary of Reports (FDA)

https://www.ncbi.nlm.nih.gov/pubmed/26393387


Cipro Induced Chondrotoxicity Tendinopathy

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.925.203&rep=rep1&type=pdf


FDA Warning and Study Highlight

https://jamanetwork.com/journals/jama/article-abstract/1737039?redirect=true


Levofloxacin-Induced Tendinopathy of the Hip

https://www.ncbi.nlm.nih.gov/pubmed/22535840

http://journals.sagepub.com/doi/abs/10.1345/aph.1Q635?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed


Fluoroquinolone Adverse Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691


Anxiogenic and proconvulsant effect of gatifloxacin in mice

https://www.ncbi.nlm.nih.gov/pubmed/18022617


Safety of fluoroquinolones update

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/pdf/JID13054.pdf


Pathogenesis of quinolone...

https://www.ncbi.nlm.nih.gov/pubmed/15633793


Synergistic Effect of Ofloxacin and Magnesium Deficiency on Joint

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127237/pdf/0776.pdf


Comparative Evaluation of Ultrastructural

http://journals.sagepub.com/doi/pdf/10.1177/019262339602400507


Cipro study Toxicity

http://studyres.com/doc/7164464/chapter-3-fluoroquinolone-toxicity-to-tendons


Toxicological studies on pipemidic acid versus effect on diarthrodial joints

https://www.ncbi.nlm.nih.gov/pubmed/105148


Quinolone-Induced Arthropathy in Neonatal Foals

https://www.researchgate.net/profile/Eden_Bermingham/publication/242317581_Quinolone-Induced_Arthropathy_in_Neonatal_Foals/links/53f1e87b0cf272810e4c74a9.pdf


Quinolone arthropathy in immature rabbits treated with the fluoroquinolone, (1)

https://www.ncbi.nlm.nih.gov/pubmed/8811288

http://www.sciencedirect.com/science/article/pii/S0940299396800030?via%3Dihub


Investigation of fluoroquinolone-induced myalgia

http://onlinelibrary.wiley.com/doi/10.1002/art.10094/pdf


Fluoroquinolone-Mediated Inhibition of Cell Growth

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424257/pdf/pone.0042960.pdf


Comparison of plasma and tissue disposition of

https://www.ncbi.nlm.nih.gov/pubmed/25372241


Treatment of the Fluoroquinolone Associated Disability –

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf

https://www.hindawi.com/journals/omcl/2017/8023935/


Fluoroquinolones-Induced Tendinitis and Tendon

https://www.ncbi.nlm.nih.gov/pubmed/17580216


Fluoroquinolones May Increase Aortic

https://www.medpagetoday.com/cardiology/prevention/53950


Fluoroquinolone toxicity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981197/pdf/cp-2012-4-e87.pdf


Nanobiotics Effects of Fluoroquinolones in Mammalian Cells 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf

http://www.jbc.org/content/290/36/22287.full.pdf


Ultrastructural changes induced by the des-F(7)-quinolone garenoxacin

https://www.ncbi.nlm.nih.gov/pubmed/12811465

https://link.springer.com/article/10.1007/s00204-003-0478-3


Ultrastructural Changes in Articular Cartilages of

http://journals.sagepub.com/doi/pdf/10.1177/030098589202900307


Toxicological Assessment of Trace b-Diketone Antibiotic

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111491/pdf/pone.0102731.pdf


Toxic Effects of Quinolone Antibacterial Agents on the Musculoskeletal System

https://www.ncbi.nlm.nih.gov/pubmed/9437810


Third and Fourth Generation Fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/24410307


The perils of prescribing fluoroquinolones 

http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true

https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf


The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro 

https://www.researchgate.net/profile/YONGJIAN_QI2/publication/51628936_The_effects_of_levofloxacin_on_rabbit_anterior_cruciate_ligament_cells_in_vitro/links/59de3debaca27247d794298f/The-effects-of-levofloxacin-on-rabbit-anterior-cruciate-ligament-cells-in-vitro.pdf


Toxic Effects of Levofloxacin on Rat Annulus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237079/pdf/medscimonit-20-2205.pdf


Synergistic effects of dexamethasone and quinolones on human-derived 

https://www.ncbi.nlm.nih.gov/pubmed/20034766

http://www.ijaaonline.com/article/S0924-8579(09)00483-X/fulltext


Safety issues and drug—drug

https://www.ncbi.nlm.nih.gov/pubmed/25423877

https://www.researchgate.net/publication/268816291_Safety_issues_and_drug-drug_interactions_with_commonly_used_quinolones


Risk of Aortic Dissection and Aortic Aneurysm

https://www.ncbi.nlm.nih.gov/pubmed/26436523

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2451282


Quinolone-induced arthropathy an update focusing on new mechanistic and clinical

https://www.ncbi.nlm.nih.gov/pubmed/18835137

https://www.sciencedirect.com/science/article/pii/S0924857908003531


Quinolone associated tendonitis COPD

https://www.researchgate.net/publication/11257902_Quinolone-associated_tendonitis_A_potential_problem_in_COPD

https://link.springer.com/article/10.1007/BF03173892


Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells

https://pdfs.semanticscholar.org/0eef/309042885bf1fe3befcf0b5ccb7540840342.pdf


Further analysis of the risk of adverse birth outcome after maternal use of fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/16144758


Fluoroquinolone-Induced Tendinopathy

https://pdfs.semanticscholar.org/b8ff/5ef2016ac6548d0976a2189a744666a06edf.pdf



Effects of Ofloxacin on Integrin Expression

https://www.ncbi.nlm.nih.gov/pubmed/20650069


Pharmacological agents and impairment of fracture healing -What is the evidence 

https://pdfs.semanticscholar.org/7009/158be1562b272f07cc3d7f79fb78dc724c02.pdf


Pathogenesis of Tendon Rupture Secondary to Fluoroquinoloone Therapy

https://www.ncbi.nlm.nih.gov/pubmed/17538473

http://journals.lww.com/orthopaedicnursing/Abstract/2007/05000/Pathogenesis_of_Tendon_Rupture_Secondary_to.9.aspx


Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin

http://www.academia.edu/26929187/Oral_toxicity_of_pefloxacin_norfloxacin_ofloxacin_and_ciprofloxacin_comparison_of_biomechanical_and_histopathological_effects_on_Achilles_tendon_in_rats

https://www.ncbi.nlm.nih.gov/pubmed/21628961


Oral Fluoroquinolones and the Risk

https://jamanetwork.com/journals/jama/fullarticle/1148331


Oral Fluoroquinolone and Aortic Dissection and Aortic Aneurysm Risk

http://www.acc.org/latest-in-cardiology/journal-scans/2015/10/06/15/33/risk-of-aortic-dissection-and-aortic-aneurysm-in-patients-taking-oral-fluoroquinolone


Ofloxacin induces oxidative damage to joint chondrocytes of juvenile rabbits

https://www.ncbi.nlm.nih.gov/pubmed/19818344


Ofloxacin induces apoptosis in microencapsulated juvenile rabbit

https://www.ncbi.nlm.nih.gov/pubmed/17961619


Ocular toxicity of fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/17760640


Non-antibiotic-effects-of-fluoroquinolones-in-mammalian-cells

http://www.jbc.org/content/290/36/22287.full.pdf


Levofloxacin-induced Achilles tendon rupture in a patient with systemic

https://www.ncbi.nlm.nih.gov/pubmed/17029067

https://link.springer.com/article/10.1007/s10165-005-0393-y


Levofloxacin-induced Achilles tendinitis and tendon rupture

http://www.europeangeriaticmedicine.com/article/S1878-7649(12)00116-7/abstract

http://www.sciencedirect.com/science/article/pii/S1878764912001167


Musculoskeletal Complications of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/21333952


Levofloxacin-Induced Tendon Rupture A Case Report and Review of the Literature 

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.878.6133&rep=rep1&type=pdf


Fluoroquinolones influence the intracellular calcium handling in individuals 

http://onlinelibrary.wiley.com/doi/10.1002/mus.22021/full


In vitro study of cytotoxicity of quinolones on rabbit tenocytes 

https://link.springer.com/article/10.1023/A:1007435025616


In Vitro Evidence for Effects of Magnesium Supplementation 

https://www.ncbi.nlm.nih.gov/pubmed/11280370


Fluoroquinolone Induced Tendinopathy

https://www.jstage.jst.go.jp/article/tjem/226/4/226_4_251/_pdf


Role of the new Fluoroquinolones in pediatric practice

http://journals.lww.com/pidj/Citation/1992/11120/Role_of_the_new_quinolones_in_pediatric_practice_.10.aspx


Fluoroquinolones cause changes in extracellular matrix, signaling proteins

https://www.ncbi.nlm.nih.gov/pubmed/15890441


Fluoroquinolones and collagen associated severe adverse events a longitudinal cohort study

http://bmjopen.bmj.com/content/bmjopen/5/11/e010077.full.pdf


Effects of sparfloxacin on CNS functions

https://www.ncbi.nlm.nih.gov/pubmed/16701999


Effects of Ofloxacin in Integrin Expression

https://www.ncbi.nlm.nih.gov/pubmed/20650069


Effects of fluoroquinolones and glucocorticoids on cultivated tendon cells in vitro

https://www.ncbi.nlm.nih.gov/pubmed/20650258


Effects of fuoroquinolones and magnesium defciency

https://link.springer.com/article/10.1007/s002040050521


Effect of various concentrations of antibiotics on osteogenic cell viability and activity 

https://www.ncbi.nlm.nih.gov/pubmed/21567453


Influence on Mitochondria and Cytotoxicity of Different Antibiotics https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797653/pdf/0729-05.pdf


In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon

http://jpet.aspetjournals.org/content/jpet/308/1/394.full.pdf


Gene expression profiles in the articular cartilage of juvenile rats receiving the 

https://www.ncbi.nlm.nih.gov/pubmed/18572299


Effect of levofloxacin on glycosaminoglycan and DNA synthesis of cultured rabbit 

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.845.2627&rep=rep1&type=pdf


Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells

https://www.ncbi.nlm.nih.gov/pubmed/23813946


Positive Association Between Fluoroquinolone Exposure and Tendon Disorders: A Nationwide Population-Based Cohort Study in Taiwan

https://pubmed.ncbi.nlm.nih.gov/35387340/  


Quinolones-Induced Musculoskeletal, Neurological, and Psychiatric ADRs: A Pharmacovigilance Study Based on Data From the Italian Spontaneous Reporting System

https://www.frontiersin.org/articles/10.3389/fphar.2020.00428/full?fbclid=IwAR1rjbin78QQ1gCmHOJc4c7Yj7RS4_ljIEgZ_mLRZoJo5CE3GPmjPoEqfxw&mibextid=Zxz2cZ



  • About Us
  • FDA Warnings
  • EMA Warnings
  • Toxicity Warnings
  • Drug List
  • Chemical Composition
  • Library A-M
  • Library N-Z
  • Most Important Studies
  • Our Sponsored Research
  • Supporting Studies
  • Find Help
  • Contact Us

Copyright © 2020  - All Rights Reserved.

Powered by GoDaddy Website Builder