Welcome to our library A-M
This extensive library of publications below, reflect the work of scientists around the globe. Segregated by category alphabetically, all relate to either Fluoroquinolone, Quinolone or DNA study.
If you have found these publications useful, any size contribution to our foundation would be greatly appreciated.
ACCUMULATION
Pharmacokinetic prediction of levofloxacin accumulation in tissue and its association to tendinopathy
Concurrent determination of four fluoroquinolones in catfish, shrimp, and salmon by liquid chromatography with fluorescence detection
https://www.ncbi.nlm.nih.gov/pubmed/12477191
Screening of Antibiotic Residues in Poultry Liver, Kidney and Muscle in Khartoum State, Sudan
https://pdfs.semanticscholar.org/5640/556fcccf7260990ad15703928eab8db73058.pdf
Factors influencing the intracellular activity of fluoroquinolones: a study using levofloxacin in a Staphylococcus aureus THP-1 monocyte model https://pubmed.ncbi.nlm.nih.gov/16533826/
ADDUCTION/SPECTOGRAPHY/QUINOLONE INTERACTIONS
DNA Adduct Profiles
https://www.sciencedirect.com/science/article/pii/S1367593107000701
https://www.ncbi.nlm.nih.gov/pubmed/17574899
DNA Adducts – mutations – cancer
https://www.ncbi.nlm.nih.gov/pubmed/11162720
DNA Adducts Endogenous
http://journals.sagepub.com/doi/pdf/10.1177/019262330002800308
DNA Adduction in Context: Native Metabolic Activation of Affoobdorne Procarcinogen and Adducted Oligonucleotide Sequencing Monitored by LC-MS/MS
https://repository.library.northeastern.edu/files/neu:728/fulltext.pdf
DNA Adducts and Their Consequences
https://www-legacy.dge.carnegiescience.edu/SCOPE/SCOPE_52/SCOPE_52_2.01_Beland_29-56.pdf
DNA Adducts: Endogenous and Induced
https://www.ncbi.nlm.nih.gov/pubmed/10862557
Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection
https://www.ncbi.nlm.nih.gov/pubmed/16272169
https://academic.oup.com/carcin/article/27/2/178/2476104
On the Effect of Covalently Appended Quinolones on Termini of DNA Duplexes
http://pubs.acs.org/doi/abs/10.1021/ja0125117
Learn more about DNA Adduct
https://www.sciencedirect.com/topics/neuroscience/dna-adduct
DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes
https://www.ncbi.nlm.nih.gov/pubmed/19122895
Acyl Glucuronidation of fluoroquinolone antibiotics by the udpglucuronosyltransferase 1A subfamily in human liver microsomes
https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf
Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action?
https://www.ncbi.nlm.nih.gov/pubmed/25515946
Tandem mass spectrometric study of ciprofloxacin–poly(ethylene glycol) conjugate in the presence of alkali metal ions
https://www.sciencedirect.com/science/article/pii/S1387380608002108
Molecular Docking Experiments of 4-Oxotheino [3,2-c] quinoline-2-carboxylates with DNA and their Potential Anticancer Property
Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells
https://www.ncbi.nlm.nih.gov/pubmed/23813946
A reply: “Do quinolones bind to DNA” – Yes
https://www.sciencedirect.com/science/article/pii/0006295289905054
Spectroscopic Studies on the Binding of Some Fluoroquinolones with DNA
https://www.ncbi.nlm.nih.gov/pubmed/23434558
Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg2+ to the second metal binding site
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720527/pdf/nihms749655.pdf
Characterization of ciprofloxacin binding to the linear single- and double-stranded DNA
https://www.ncbi.nlm.nih.gov/pubmed/12890558
Mechanism of Quinolone Inhibition of DNA Gyrase
http://www.jbc.org/content/264/5/2973.full.pdf
Interaction between ciprofloxacin and DNA mediated by Mgt + -ions
https://www.ncbi.nlm.nih.gov/pubmed/21820989
Influence of copper(II) and magnesium(II) ions on the ciprofloxacin binding to DNA
http://www.bf.uni-lj.si/fileadmin/groups/2747/Zaposleni/Natasa_Poklar_Ulrih/2003-NPU-JIB.pdf
Interaction between ciprofloxacin and DNA mediated by Mg2_-ions
https://www.sciencedirect.com/science/article/pii/S0020169302009337
Interaction study of ciprofloxacin with human telomeric DNA by spectroscopy and molecular docking
https://www.ncbi.nlm.nih.gov/pubmed/23434548
Structural Insight into a Quinolone-Topoisomerase II-DNA Complex
http://www.jbc.org/content/274/24/17226.full.pdf
The complexes of metal ions with Fluoroquinolones
https://link.springer.com/article/10.1134/S1070328409020018
https://www.researchgate.net/publication/226755953_The_complexes_of_metal_ions_with_fluoroquinolones
Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism
http://www.jbc.org/content/270/37/21429.full.pdf
DNA adduct profiles: chemical approaches to addressing the biological impact of DNA damage from small molecules
https://www.ncbi.nlm.nih.gov/pubmed/17574899
https://www.sciencedirect.com/science/article/abs/pii/S1367593107000701?via%3Dihub
DNA adduction in context: native metabolic activation of a foodborne procarcinogen and adducted oligonucleotide sequencing monitored by LC-MS/MS
DNA Adducts – mutations – cancer
http://aether.cmi.ua.ac.be/artikels/MB_30229.pdf
Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855444/pdf/pone.0010186.pdf
Antibacterial and Anticancer Drugs Interaction with DNA
https://pdfs.semanticscholar.org/9298/604f37c935936a3e8384829c748af820944a.pdf
Effect of metal ions on some pharmacologically relevant interactions involving fl uoroquinolone antibiotics https://www.researchgate.net/profile/Neelam_Seedher/publication/50591479_Effect_of_metal_ions_on_some_pharmacologically_relevant_interactions_involving_fl_uoroquinolone_antibiotics/links/57f4ce4808ae8da3ce54ea48/Effect-of-metal-ions-on-some-pharmacologically-relevant-interactions-involving-fl-uoroquinolone-antibiotics.pdf
DNA Adducts and Their Consequences
https://dge.carnegiescience.edu/SCOPE/SCOPE_52/SCOPE_52_2.01_Beland_29-56.pdf
On the Effect of Covalently Appended Quinolones on Termini of DNA Duplexes
https://www.ncbi.nlm.nih.gov/pubmed/11960452
Synthesis, characterization and DNA binding of magnesium–ciprofloxacin (cfH) complex [Mg(cfl 2]. 2.5H2O
http://www.bf.uni-lj.si/fileadmin/groups/2747/Zaposleni/Natasa_Poklar_Ulrih/2006-NPU-JIB.pdf
DNA Adducts: Endogenous and Induced
Drug bioactivation and protein adduct formation in the pathogenesis of
Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection
https://www.ncbi.nlm.nih.gov/pubmed/16272169
Molecular details of quinolone–DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192833/pdf/gki795.pdf
Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode
http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract
A “Double-Edged” Scaffold Antitumor Power within the Antibacterial Quinolone
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997924/pdf/CMC-23-520.pdf
A theoretical-experimental study on the structure and activity of certain quinolones and the interaction of their Cu(II)-Complexes on a DNA model https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365236/pdf/MBD-07-301.pdf
Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950664/pdf/gkt1109.pdf
Chemo-Targeting_DNA_topoisomerase_II in cancer Chemotherapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748742/pdf/nihms120024.pdf
Copper(II)–fluoroquinolone complexes with anti-Trypanosoma cruzi activity and DNA binding ability
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746275/pdf/BCA2016-5027404.pdf
Crystal structure, characterisation and biological activity of copper(II)-ciprofloxacin inoic compound https://www.researchgate.net/publication/279899521_Crystal_structure_characterisation_and_biological_activity_of_copperII-ciprofloxacin_ionic_compound
DNA interaction, cytotoxicity, antibacterial and antituberculosis activity of oxovanadium(IV) complexes derived from fluoroquinolones and 4-hydroxy-5-((4-ydroxyphenyl)diazenyl)thiazole-2(3H)-thione
http://pubs.rsc.org/-/content/articlelanding/2015/ra/c5ra01222h/unauth#!divAbstract
DNA interaction and cytotoxic activities of square planar platinum(II) complexes with N, S-donor ligands.
https://www.ncbi.nlm.nih.gov/pubmed/24632234
https://www.sciencedirect.com/science/article/pii/S1386142514002406?via%3Dihub
Development of a Monoclonal Antibody-Based Broad-Specificity ELISA for fluoroquinolone Antibiotics in Foods and Molecular Modeling Studies of Cross-Reactive Compounds
https://www.ncbi.nlm.nih.gov/pubmed/17511422
Norfloxacin La(III)-based complex Synthesis characterization and DNA binding studies
https://www.tandfonline.com/doi/abs/10.1080/00958972.2015.1065320?journalCode=gcoo20
NMR investigation of pefloxacin/cation/DNA interactions. Mg 2 + and Ca 2 + Binding
https://www.sciencedirect.com/science/article/pii/S037851739700389X
Molecular Analysis of Yeast and Human Type II Topoisomerases
http://www.jbc.org/content/274/40/28246.full.pdf
Mg2 +-Mediated Binding of 6-Substituted Quinolones to DNA: Relevance to Biological Activity
https://www.ncbi.nlm.nih.gov/pubmed/9801827
Quinolones: Action and Resistance Updated
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182077/pdf/CTMC-9-981.pdf
Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.361.8571&rep=rep1&type=pdf
The Structure of DNA-Bound Human Topoisomerase II Alpha: Gonformational Mechanisms for Goordinating Inter-Subunit Interactions with DNA Cleavage
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584591/pdf/nihms397579.pdf
The RuvAB Branch Migration Complex Can Displace Topoisomerase IV_Quinolone_DNA Ternary Complexes*
http://www.jbc.org/content/278/48/48485.full.pdf
In Vitro Evaluation of Zn–Norfloxacin Complex as a Potent Cytotoxic and Antibacterial Agent, Proposed Model for DNA Binding
https://www.ncbi.nlm.nih.gov/pubmed/23636652
Pharmacokinetic interactions related to the chemical structures of fluoroquinolones
https://academic.oup.com/jac/article/37/suppl_A/41/816317
Type II Topoisomerases as Targets for Quinolone
Antibacterials: Turning Dr. Jekyll into Mr. Hyde
https://www.ncbi.nlm.nih.gov/pubmed/11254893
Cipro Docking to DNA
ASSAY TECHNIQUES
A one-step chemiluminescence immunoassay for 20 fluoroquinolone residues in fish and shrimp based on a single chain Fv–alkaline phosphatase fusion protein
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AY/c5ay01410g#!divAbstract
A simple and rapid high performance liquid chromatography method to determine levofloxacin in human plasma and its use in a bioequivalence study
http://www.ddtjournal.com/action/downloaddoc.php?docid=63
Acyl glucuronidation of fluoroquinolone antibiotics by the udpglucuronosyltransferase 1A subfamily in human liver microsomes
https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf
Analytical profile of the fluoroquinolone antibacterials. I. Ofloxacin
https://www.ajol.info/index.php/ajb/article/view/58495/46839
Chemiluminescence competitive indirect enzyme immunoassay for 20 fluoroquinolone residues in fish and shrimp based on a single-chain variable fragment
https://www.ncbi.nlm.nih.gov/pubmed/23842902
https://link.springer.com/article/10.1007%2Fs00216-013-7174-9
BACTERIAL RESISTANCE
Topoisomerase mutations and efflux are associated with fluoroquinolone resistance in Enterococcus faecalis
CARCINOGENICITY
Quinolone antibacterials: a new class of photochemical carcinogens
https://www.ncbi.nlm.nih.gov/pubmed/9085565
http://www.sciencedirect.com/science/article/pii/S1011134496074258?via%3Dihub
Study for genotoxicity and carcinogenicity of quinolone antimicrobials in mammals
Photochemical mutagenicity of phototoxic and photochemically carcinogenic fluoroquinolones in comparison with the photostable moxifloxacin.
https://www.ncbi.nlm.nih.gov/pubmed/11131036
https://link.springer.com/article/10.1007%2Fs002040000162?LI=true
CARDIAC
Preclinical safety evaluation of moxifloxacin, a novel fluoroquinolone
https://www.ncbi.nlm.nih.gov/pubmed/10382881
Cardiovascular and metabolic safety profiles of the fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/21958023
Acute and subacute (20-d) oral dose toxicity study of modified fluoroquinolone compound 6C in BALB/c mice
https://www.tandfonline.com/doi/abs/10.3109/15569543.2015.1076483
http://www.tandfonline.com/doi/abs/10.3109/15569543.2015.1076483?src=recsys&journalCode=itxr20
Adverse Drug Reactions Related to the Use of Fluoroquinolone Antimicrobials
https://www.ncbi.nlm.nih.gov/pubmed/12534327
Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092995/pdf/hir-17-58.pdf
https://www.ncbi.nlm.nih.gov/pubmed/21818458
Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy
https://www.ncbi.nlm.nih.gov/pubmed/19387967
https://www.ncbi.nlm.nih.gov/pubmed/19387967
Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study
http://bmjopen.bmj.com/content/bmjopen/5/11/e010077.full.pdf
Quinolones: Cardioprocective or Cartiotoxic?
https://www.ncbi.nlm.nih.gov/pubmed/14675020
http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8159.2003.00367.x/abstract
https://www.ncbi.nlm.nih.gov/pubmed/14675020
Relationship of cellular topoisomerase II a inhibition to cytotoxicity and published genotoxicity of fluoroquinolone antibiotics in V79 cells
https://www.sciencedirect.com/science/article/pii/S0009279713000057
https://www.ncbi.nlm.nih.gov/pubmed/23340199
Synthesis, characterization, antimicrobial, SODmimic and DNA interaction behavior of copper(II) complexes with pefloxacin and phenanthroline derivatives
http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0149198&type=printable
https://onlinelibrary.wiley.com/doi/abs/10.1002/aoc.1766
Effect of Macrolide and Fluoroquinolone Antibacterials on the Risk of Ventricular Arrhythmia and Cardiac Arrest
https://www.ncbi.nlm.nih.gov/pubmed/19236122
Quinolone induced QT interval prolongation: a not-so-unexpected class effect
https://www.ncbi.nlm.nih.gov/pubmed/10797074
Oral Fluoroquinolone and Aortic Dissection and Aortic Aneurysm Risk
https://www.ncbi.nlm.nih.gov/pubmed/26436523
Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone
https://www.ncbi.nlm.nih.gov/pubmed/26436523
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2451282
Risks of Cardiac Arrhythmia and Mortality Among Patients Using New-Generation
Macrolides, Fluoroquinolones, and β-Lactam/ β-Lactamase Inhibitors: A Taiwanese Nationwide Study
https://www.ncbi.nlm.nih.gov/pubmed/25409476
Safety issues and drug—drug interactions with commonly used quinolones
https://www.ncbi.nlm.nih.gov/pubmed/25423877
Torsades de pointes associated with fluoroquinolones: Importance of concomitant risk factors
https://www.ncbi.nlm.nih.gov/pubmed/15001976
The perils of prescribing fluoroquinolones
https://www.mdedge.com/familymedicine/article/65086/perils-prescribing-fluoroquinolones
https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf
The Safety Profile of the Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/10945507
The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel
https://www.ncbi.nlm.nih.gov/pubmed/23711922
http://www.sciencedirect.com/science/article/pii/S0960894X13005647?via%3Dihub
Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
https://www.ncbi.nlm.nih.gov/pubmed/24410307
Toxicological Assessment of Trace b-Diketone Antibiotic Mixtures on Zebrafish (Danio rerio) by Proteomic Analysis
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102731
https://www.ncbi.nlm.nih.gov/pubmed/25062015
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111491/pdf/pone.0102731.pdf
Mechanism of hERG Kþ channel blockade by the fluoroquinolone antibiotic moxifloxacin
https://www.ncbi.nlm.nih.gov/pubmed/16474415
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1760709/pdf/147-0706678a.pdf
Fluoroquinolones May Increase Aortic Aneurysm Risk
https://www.medpagetoday.com/cardiology/prevention/53950
Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect – comprehensive overview of clinical trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785617/pdf/40360_2016_Article_53.pdf
https://www.ncbi.nlm.nih.gov/pubmed/26960809
Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419912/pdf/bph0166-1694.pdf
https://www.ncbi.nlm.nih.gov/pubmed/22289150
The effect of levofloxacin and moxifloxacin on cardiovascular functions of rats with streptozotocin induced diabetes
https://www.ncbi.nlm.nih.gov/pubmed/22621918
Fluoroquinolone induces human aortic fibroblast-mediated extracellular matrix dysregulation
http://www.onlinecjc.ca/article/S0828-282X(17)30468-3/pdf
https://www.onlinecjc.ca/article/S0828-282X(17)30468-3/abstract
Safety of fluoroquinolones: An update
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/pdf/JID13054.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/
The Quinolones, Ch 16, Prospects
https://www.sciencedirect.com/science/article/pii/B9780120595174500179
Rates of Torsades de Pointes Associated with Ciprofloxacin, Ofloxacin, Levofloxacin, Gatifloxacin, and Moxifloxacin
https://www.ncbi.nlm.nih.gov/pubmed/11765299
http://onlinelibrary.wiley.com/doi/10.1592/phco.21.20.1468.34482/abstract
Fluoroquinolone Adverse Effects and Drug Interactions
http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full
https://www.ncbi.nlm.nih.gov/pubmed/11642691
Sparfloxacin, a Fluoroquinolone Antibiotic, Slows Inactivation of L-Type a2D C Current in Neonatal Rat Ventricular Myocytes
http://www.cell.com/biophysj/pdf/S0006-3495(14)01834-7.pdf
New Evidence Against Use of Fluoroquinolones in Aortic Disease
https://www.medscape.com/viewarticle/949358
Effects of Fluroquinolone Exposure on Aortic Dissection, Aneurysm Outcomes
Oral fluoroquinolones and risk of aortic or mitral regurgitation: A nationwide nested case-control study
Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study
CARTILAGE
Clinical toxicological aspects of fluoroquinolones
Comparative Evaluation of Ultrastructural Changes in Articular Cartilage of Ofioxacin-Treated and Magnesium-Deficient Immature Rats*
https://www.ncbi.nlm.nih.gov/pubmed/8923679
Confirmation of fluoroquinolone residues in salmon and shrimp tissue by LC/MS: Evaluation of single quadrupole and ion trap instruments
CHEMISTRY
Investigating the fluoroquinolone-topoisomerase interaction by use of novel fluoroquinolone and quinazoline analogs
http://ir.uiowa.edu/cgi/viewcontent.cgi?article=2403&context=etd
https://ir.uiowa.edu/etd/1018/
The Complexes of Metal Ions with Fluoroquinolones
https://link.springer.com/article/10.1134/S1070328409020018
Synthesis, characterization, antimicrobial and cytotoxicity studies of some transition metal complexes with gemifloxacin
https://link.springer.com/article/10.1007/s00706-015-1507-7
A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods
https://link.springer.com/article/10.1007/s00204-009-0509-9
https://www.ncbi.nlm.nih.gov/pubmed/20049419
Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode
https://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f
Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones-Shaping the Fifth Generation https://pubmed.ncbi.nlm.nih.gov/34452252/
CHONDROCYTES
Comparative Evaluation of Ultrastructural Changes in Articular Cartilage of Ofloxacin-Treated and Magnesium-Deficient Immature Rats*
CLINICAL STUDY
Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro
http://www.nmcth.edu/images/gallery/Editorial/xRZVmps_ambulkar.pdf
Fluoroquinolones and Musculoskeletal Toxicity in Pediatrics: Is The Fear Real?
http://sites.utexas.edu/pharmacotherapy-rounds/files/2015/09/kuriakose11-21-14.pdf
Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092995/pdf/hir-17-58.pdf
https://www.ncbi.nlm.nih.gov/pubmed/21818458
Diagnostic failure of ciprofloxacin-induced spontaneous bilateral Achilles tendon rapture: case-reported and medical legal consideration
https://www.ncbi.nlm.nih.gov/pubmed/21658328
Emergency Department Visits for Antibiotic- Associated Adverse Events
https://www.ncbi.nlm.nih.gov/pubmed/18694344
https://pdfs.semanticscholar.org/1899/bafdc7edb82d8a70c042bf015db299a2a5b3.pdf
Severe hypoglycemia associated with levofloxacin in Type 2 diabetic patients receiving polytherapy: two case reports
https://www.ncbi.nlm.nih.gov/pubmed/22456302
Ciprofloxacin-associated choreoathetosis in a haemodialysis patient
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645130/pdf/bcr-2013-009293.pdf.
https://www.ncbi.nlm.nih.gov/pubmed/23605987
Unnecessary use of fluoroquinolone antibiotics in hospitalized patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145580/pdf/1471-2334-11-187.pdf
https://www.ncbi.nlm.nih.gov/pubmed/21729289
US-Based Emergency Department Visits for Fluoroquinolone-Associated Hypersensitivity Reactions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635672/pdf/nihms732049.pdf
https://www.ncbi.nlm.nih.gov/pubmed/23963962
Crystal-induced acute kidney injury due to ciprofloxacin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316583/pdf/JNP-4-29.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316583/
Characterization of N-Glucuronidation of 4-(5-Pyridin-4-yl-1H– [1,2,4]triazol-3-yl)pyridine-2-carbonitrile (FYX-051): A New Xanthine Oxidoreductase Inhibitor
http://dmd.aspetjournals.org/content/dmd/35/12/2143.full.pdf
https://www.ncbi.nlm.nih.gov/pubmed/17761779
The Risk of Hepatotoxicity with Fluoroquinolones: A National Case-Control Safety Study
CNS PNS ANS Neural (see also Neural)
Preclinical safety evaluation of moxifloxacin, a novel fluoroquinolone
https://www.ncbi.nlm.nih.gov/pubmed/10382881
Reversible craniocervical dystonia associated with levofloxacin
https://clinicalmovementdisorders.biomedcentral.com/articles/10.1186/s40734-015-0021-8
COLLAGEN MUTATION AND HIF GEGRADATION
Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf
https://www.ncbi.nlm.nih.gov/pubmed/26205818
New insights in extracellular matrix remodeling and collagen turnover related pathways in cultured human tenocytes after ciprofloxacin administration
CORNEAL CYTOTOXICITY (see ocular)
Concentrations of the des-F(6)-quinolone garenoxacin in plasma and joint cartilage of immature rats
CYTOTOXITY
Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro
http://www.nmcth.edu/images/gallery/Editorial/xRZVmps_ambulkar.pdf
https://www.ncbi.nlm.nih.gov/pubmed/20334059
4-Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes In Vitro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/
A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods
https://www.ncbi.nlm.nih.gov/pubmed/20049419
Alteration of the Endocytotic Pathway by Photosensitization with Fluoroquinolones
http://onlinelibrary.wiley.com/doi/10.1562/0031-8655(2000)0720458AOTEPB2.0.CO2/full
https://www.ncbi.nlm.nih.gov/pubmed/11045714
Effects of Difloxacin on the Metabolism of Glycosaminoglycans and Collagen in Organ Cultures of Articular Cartilage
https://www.sciencedirect.com/science/article/pii/S0272059083710341
Calcium Signals Are Affected by Ciprofloxacin as a Consequence of Reduction of Mitochondrial DNA Content in Jurkat Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/pdf/1543-05.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/
Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action?
https://www.ncbi.nlm.nih.gov/pubmed/25515946
Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test
https://hal.archives-ouvertes.fr/hal-01191262/document
https://www.ncbi.nlm.nih.gov/pubmed/22047769
Assessment on the adverse effects of Aminoglycosides and Flouroquinolone on sperm parameters and male reproductive tissue: A systematic review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426151/pdf/ijrm-3-125.pdf
https://www.ncbi.nlm.nih.gov/pubmed/26000002
Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/pdf/nihms-509241.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/
Biological activities of some Fluoroquinolones-metal complexes
https://www.ajol.info/index.php/ijmbr/article/view/91824
Butachlor induced dissipation of mitochondrial membrane potential, oxidative DNA damage and necrosis in human peripheral blood mononuclear cells
https://www.ncbi.nlm.nih.gov/pubmed/22884430
Copper(II) complexes with norfloxacin and neutral terpyridines: Cytotoxic, antibacterial, superoxide dismutase and DNA-interaction approach
https://www.sciencedirect.com/science/article/pii/S0277538712002112
Ciprofloxacin induced chondrotoxicity and tendinopathy
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.925.203&rep=rep1&type=pdf
https://pdfs.semanticscholar.org/31e5/c6845352b87aba23c60b714d7253cc2ab2de.pdf
Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms
https://www.ncbi.nlm.nih.gov/pubmed/25902267
Combined Use of In Vitro Phototoxic Assessments and Cassette Dosing Pharmacokinetic Study for Phototoxicity Characterization of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160149/pdf/12248_2011_Article_9292.pdf
https://www.ncbi.nlm.nih.gov/pubmed/21739333
Comparison of fluoroquinolones: cytotoxicity on human corneal epithelial cells
https://www.nature.com/articles/eye2009179.pdf
https://www.ncbi.nlm.nih.gov/pubmed/19648900
Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells
https://www.ncbi.nlm.nih.gov/pubmed/23813946
Cytotoxicity of Quinolones toward Eukaryotic Cells
http://www.jbc.org/content/267/19/13150.full.pdf
https://www.ncbi.nlm.nih.gov/pubmed/1320012
Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.972.1373&rep=rep1&type=pdf
Effect of levofloxacin on glycosaminoglycan and DNA synthesis of cultured rabbit
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.845.2627&rep=rep1&type=pdf
Gene expression profiles in the articular cartilage of juvenile rats receiving the
https://www.ncbi.nlm.nih.gov/pubmed/18572299
Lysosomal Membrane Permeabilization Induces Cell Death
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193790/pdf/20021952.pdf
In vitro study of cytotoxicity of quinolones on rabbit tenocytes
https://link.springer.com/article/10.1023/A:1007435025616
In Vitro Evidence for Effects of Magnesium Supplementation on
https://www.ncbi.nlm.nih.gov/pubmed/11280370
Fluoroquinolone Induced Tendinopathy
https://www.jstage.jst.go.jp/article/tjem/226/4/226_4_251/_pdf
Fluoroquinolones cause changes in extracellular matrix, signalling proteins,
https://www.ncbi.nlm.nih.gov/pubmed/15890441
Evaluation of gatifloxacin for eye
https://www.ncbi.nlm.nih.gov/pubmed/25028261
http://journals.sagepub.com/doi/abs/10.1177/0960327114530743
Evaluation of ameliorative potential of supranutritional selenium on
https://www.ncbi.nlm.nih.gov/pubmed/27083143
Effects of Ofloxacin in Integrin Expression
https://www.ncbi.nlm.nih.gov/pubmed/20650069
Effects of fluoroquinolones and glucocorticoids on cultivated tendon cells in vitro
https://www.ncbi.nlm.nih.gov/pubmed/20650258
Effect of various concentrations of antibiotics on osteogenic cell viability and activity
https://www.ncbi.nlm.nih.gov/pubmed/21567453
Effect of norfloxacin and moxifloxacin on melanin synthesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf
Drug induced liver injury Interactions between drug properties
https://www.ncbi.nlm.nih.gov/pubmed/25912521
Drug features that contribute to the activity of quinolones against mammalian
http://www.myquinstory.info/wp-content/uploads/2013/09/Activity-of-Quinolones-Mammalian-Cells.pdf
Detection and Prevention of Ocular Phototoxicity of Ciprofloxacin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910230/pdf/nihms-204214.pdf
Several gene programs are induced in ciprofloxacin-treated
https://www.ncbi.nlm.nih.gov/pubmed/12949250
Role of Mitochondria in Ciprofloxacin Sperm Cells
http://eprints.umsu.ac.ir/786/1/1933719113477482.pdf
Investigations into the concept of a threshold for topoisomerase
https://academic.oup.com/mutage/article/18/4/345/1079374
Influence on Mitochondria and Cytotoxicity of Different Antibiotics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797653/pdf/0729-05.pdf
In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon
http://jpet.aspetjournals.org/content/jpet/308/1/394.full.pdf
Genotoxicity of topoisomerase II inhibitors An anti-infective perspective
https://www.ncbi.nlm.nih.gov/pubmed/18840496
Recent Advances in the Discovery and Development of Quinolones and Analogues as
https://books.google.com/books?hl=en&lr=&id=SJoxUN91vK4C&oi=fnd&pg=PA179#v=onepage&q&f=false
Effect of new synthetically prepared quinolone
http://www.acs.chtf.stuba.sk/papers/acs_0058.pdf
Quinolone-induced arthropathy an update focusing on new mechanistic and clinical
https://www.ncbi.nlm.nih.gov/pubmed/18835137
https://www.sciencedirect.com/science/article/pii/S0924857908003531
Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells
https://pdfs.semanticscholar.org/0eef/309042885bf1fe3befcf0b5ccb7540840342.pdf
Quinolone Antibiotics Induce Shiga Toxin
https://www.ncbi.nlm.nih.gov/pubmed/10669353
https://academic.oup.com/jid/article/181/2/664/824154
Effects of Ofloxacin on Integrin Expression
https://www.ncbi.nlm.nih.gov/pubmed/20650069
Cytogenetic alterations in human lymphocyte
http://www.tandfonline.com/doi/full/10.1080/01480545.2016.1188305
https://www.ncbi.nlm.nih.gov/pubmed/27240646
CIPROFLOXACIN INHIBITS PROLIFERATION AND PROMOTES
http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf
Photosensitizing Mechanism and Identification of Levofloxacin Photoproducts at
https://www.ncbi.nlm.nih.gov/pubmed/22211524
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01068.x/abstract
Photosensitization Reactions of Fluoroquinolones and Their Biological
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.00978.x/full
https://www.ncbi.nlm.nih.gov/pubmed/21770950
Oxidative stress response of two fluoroquinolones with catalase and
https://www.ncbi.nlm.nih.gov/pubmed/23542600
Oxidative Damage to RPA Limits the Nucleotide
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669849/pdf/emss-66122.pdf
Ofloxacin induces oxidative damage to joint chndrocytes of juvenile rabbits. Excessive
https://www.ncbi.nlm.nih.gov/pubmed/19818344
Ofloxacin induces apoptosis in microencapsulated juvenile rabbit
https://www.ncbi.nlm.nih.gov/pubmed/17961619
Ocular toxicity of fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/17760640
Non-antibiotic-effects-of-fluoroquinolones-in-mammalian-cells
http://www.jbc.org/content/290/36/22287.full.pdf
Nalidixic Acid, Oxolinic Acid, and Novobiocin Inhibit
https://www.ncbi.nlm.nih.gov/pubmed/7017932
Musculoskeletal Complications of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/21333952
Moxifloxacin-induced multiple organ dysfunction possibly related
http://124.205.33.103:81/ch/reader/create_pdf.aspx?file_no=12-1691&flag=1&year_id=2013&quarter_id=7
Inhibitory Effects of Quinolones on Pro- and Eucaryotic DNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC171971/pdf/aac00066-0125.pdf
Copper complexes with phosphine derived
http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract
DNA topoisomerase targets of the fluoroquinolones
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC28420/pdf/pq013991.pdf
Cytotoxic effects and apoptosis induction of enrofloxacin in hepatic
https://www.ncbi.nlm.nih.gov/pubmed/26475364
Voreloxin Is an Anticancer Quinolone Derivative that
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855444/pdf/pone.0010186.pdf
Ultrastructural characterization of murine
https://link.springer.com/article/10.1007%2Fs00204-001-0293-7?LI=true
Ultrastructural changes induced by the des-F(7)-quinolone garenoxacin
https://www.ncbi.nlm.nih.gov/pubmed/12811465
https://link.springer.com/article/10.1007/s00204-003-0478-3
Ultrastructural Changes in Articular Cartilages of
http://journals.sagepub.com/doi/pdf/10.1177/030098589202900307
Trovafloxacin Enhances Lipopolysaccharide-Stimulated
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056269/pdf/jpet.114.214189.pdf
Toxicological Assessment of Trace b-Diketone Antibiotic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111491/pdf/pone.0102731.pdf
Toxic Effects of Quinolone Antibacterial Agents on the musculoskeletal system in juvenile rats
https://www.ncbi.nlm.nih.gov/pubmed/9437810
Third and Fourth Generation Fluoroquinolone
https://www.ncbi.nlm.nih.gov/pubmed/24410307
The Safety Prifile of the Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/10945507
The perils of prescribing fluoroquinolones
https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf
The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglyc
https://www.ncbi.nlm.nih.gov/pubmed/18706903
http://www.sciencedirect.com/science/article/pii/S0014299908008054?via%3Dihub
The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro
The effect of ciprofloxacin on sperm DNA damage, fertility potential and early
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312808/pdf/vrf-3-131.pdf
Toxic Effects of Levofloxacin on Rat Annulus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237079/pdf/medscimonit-20-2205.pdf
Synergistic effects of dexamethasone and quinolones on human-derived (1)
https://www.ncbi.nlm.nih.gov/pubmed/20034766
http://www.ijaaonline.com/article/S0924-8579(09)00483-X/fulltext
Generalized Seizure and Toxic Epidermal Necrolysis Following
Safety of fluoroquinolones update
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/pdf/JID13054.pdf
Pathogenesis of quinolone
https://www.ncbi.nlm.nih.gov/pubmed/15633793
Piperonal ciprofloxacin hydrazone induces growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010342/pdf/aps2011158a.pdf
Moxifloxacin and ciprofloxacin induces
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531397/pdf/12885_2015_Article_1560.pdf
Metal Complexes of Quinolone Antibiotics and Their Applications
http://www.mdpi.com/1420-3049/18/9/11153/htm
Melatonin can attenuate ciprofloxacin induced nephrotoxicity
https://www.ncbi.nlm.nih.gov/pubmed/27780148
In Vitro Evaluation of Zn–Norfloxacin Complex as a Potent
https://www.ncbi.nlm.nih.gov/pubmed/23636652
Gatifloxacin Induces S and G2 -phase cell cycle arrest
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047796
Chronic administration of caderofloxacin,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf
Trimethoxy-benzaldehyde levofloxacin hydrazine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716872/pdf/1475-2867-13-67.pdf
Quinolone arthropathy in immature rabbits treated with the fluoroquinolone
https://www.ncbi.nlm.nih.gov/pubmed/8811288
http://www.sciencedirect.com/science/article/pii/S0940299396800030?via%3Dihub
Probing the binding of two fluoroquinolones to lysozyme a combined
Pro-apoptotic effect of new quinolone
https://www.sciencedirect.com/science/article/pii/S0887233316300285
https://www.ncbi.nlm.nih.gov/pubmed/26916084
Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742585/pdf/kfp163.pdf
Investigation of fluoroquinolone-induced myalgia
http://onlinelibrary.wiley.com/doi/10.1002/art.10094/pdf
Fluoroquinolone-Mediated Inhibition of Cell Growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424257/pdf/pone.0042960.pdf
Treatment of the Fluoroquinolone Associated Disability –
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf
https://www.hindawi.com/journals/omcl/2017/8023935/
A “Double-Edged” Scaffold Antitumor Power within the Antibacterial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997924/pdf/CMC-23-520.pdf
Effects of Novel Fluoroquinolones on the Catalytic Activities of
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC189387/pdf/aac00038-0087.pdf
Possible involvement of DEC1 on the adverse effects of quinolone antibiotics!!!
http://www.myquinstory.info/wp-content/uploads/2010/01/Shi-2010-DEC1.pdf
https://www.ncbi.nlm.nih.gov/pubmed/20214949
Fluoroquinolone Adverse Effects and Drug Interactions
http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full
https://www.ncbi.nlm.nih.gov/pubmed/11642691
Embryotoxicity of Fluroroquinolones in Rats
https://www.researchgate.net/publication/313676604_EMBRYOTOXICITY_OF_FLUOROQUINOLONES_IN_RATS
DERMAL
Phototoxic Lesions Induced by Quinolone Antibacterial Agents in Auricular Skin and Retina of Albino Mice*
https://www.ncbi.nlm.nih.gov/pubmed/8052802
Effect of norfloxacin and moxifloxacin on melanin synthesis and antioxidant enzymes activity in normal human melanocytes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf
https://www.ncbi.nlm.nih.gov/pubmed/25433710
Adverse Drug Reactions Related to the Use of Fluoroquinolone Antimicrobials: An Analysis of Spontaneous Reports and Fluoroquinolone Consumption Data from Three Italian Regions
https://www.ncbi.nlm.nih.gov/pubmed/12534327
Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/11195848
Cutaneous leukocytoclastic vasculitis associated with levofloxacin therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892663/pdf/idr-2012-1-e11.pdf
https://www.ncbi.nlm.nih.gov/pubmed/24470918
Effect of norfloxacin and moxifloxacin on melanin synthesis and antioxidant enzymes activity in normal human melanocytes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf
https://www.ncbi.nlm.nih.gov/pubmed/25433710
Evaluation of photodegradation, phototoxicity and photogenotoxicity of ofloxacin in ointments with sunscreens and in solutions
https://www.ncbi.nlm.nih.gov/pubmed/25728226
https://www.sciencedirect.com/science/article/pii/S101113441500041X
Formation of Antigenic Photoadducts on Langerhans Cells Photoallergy to Systemically Administered Quinolone in Mice
http://www.sciencedirect.com/science/article/pii/S0022202X15408115
https://www.ncbi.nlm.nih.gov/pubmed/10692119
Ofloxacin Induced Cutaneous Reactions in Children
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525525/pdf/jcdr-9-FD01.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525525/
Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669849/pdf/emss-66122.pdf
https://www.ncbi.nlm.nih.gov/pubmed/26134950
Cutaneous Vasculitis Associated with Fluoroquinolones
http://edoc.unibas.ch/25010/1/s15010-009-8437-4.pdf
https://www.ncbi.nlm.nih.gov/pubmed/19669086
Stimulation of Prostaglandin Production by Quinolone Phototoxicity in Balb/c 3T3 Mouse Fibroblast Cells in Vitro
https://www.ncbi.nlm.nih.gov/pubmed/9143485
https://www.sciencedirect.com/science/article/pii/S0272059096922824
Safety issues and drug—drug interactions with commonly used quinolones
https://www.ncbi.nlm.nih.gov/pubmed/25423877
The photomutagenicity of fluoroquinolones and other drugs
http://www.sciencedirect.com/science/article/pii/S0378427498002355
https://www.ncbi.nlm.nih.gov/pubmed/10022282
The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay)
https://academic.oup.com/mutage/article/11/5/497/1044656
Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
https://www.ncbi.nlm.nih.gov/pubmed/24410307
Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation
https://www.sciencedirect.com/science/article/pii/S0887233316300285
https://www.ncbi.nlm.nih.gov/pubmed/26916084
Generalized Seizure and Toxic Epidermal Necrolysis Following Levofloxacin Exposure
https://www.ncbi.nlm.nih.gov/pubmed/15827068
Fluoroquinolone Adverse Effects and Drug Interactions
http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full
https://www.ncbi.nlm.nih.gov/pubmed/11642691
New insights in extracellular matrix remodeling and collagen turnover related pathways in cultured human tenocytes after ciprofloxacin administration
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838320/
Changes in the Oxidation-Reduction State of Human Dermal Fibroblasts as an Effect of Lomefloxacin Phototoxic Action
https://pubmed.ncbi.nlm.nih.gov/35741100/
DETOX
Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf
DNA INTERACTION
A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods
https://link.springer.com/article/10.1007/s00204-009-0509-9
https://www.ncbi.nlm.nih.gov/pubmed/20049419
Antibacterial and Anticancer Drugs - Interaction with DNA
http://dx.doi.org/10.1016/j.jinorgbio.2006.06.011
Interaction between ciprofloxacin and DNA mediated by Mg2+-ions
http://dx.doi.org/10.1016/S0020-1693(02)00933-7
Antibacterial Fluoroquinolone Agents - Interaction with DNA
http://dx.doi.org/10.1002/chem.200901158
Examining the Impact of Antimicrobial Fluoroquinolones on Human DNA Topoisomerase IIα and IIβ
https://pubs.acs.org/doi/10.1021/acsomega.8b03428
Mechanisms of DNA damage, repair and mutagenesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474181/
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
https://www.sciencedirect.com/science/article/pii/S1074552110001614
Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes
https://www.science.org/doi/10.1126/sciadv.abe0384
DRUG INTERACTION
Analytical profile of the fluoroquinolone antibacterials I. Ofloxacin
https://www.ajol.info/index.php/ajb/article/view/58495/46839
Fluoroquinolone-associated tendon-rupture: a summary of reports in the Food and Drug Administration’s adverse event reporting system
https://www.ncbi.nlm.nih.gov/pubmed/26393387
Ciprofloxacin induced chondrotoxicity and tendinopathy
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.925.203&rep=rep1&type=pdf
Determination of the effects of ciprofloxacin in prevention of aminoglycoside induced nephrotoxicity in rabbits: A comparative study
Effects of Fluoroquinolones and Glucocorticoids on Cultivated Tendon Cells In Vitro
https://www.ncbi.nlm.nih.gov/pubmed/20650258
Inhibitory effect of several fluoroquinolones on hepatic microsomal cytochrome P-450 1A activities in dogs
https://www.ncbi.nlm.nih.gov/pubmed/16343288
Effects of fluoroquinolones on CYP4501A and 3A in male broilers
https://www.ncbi.nlm.nih.gov/pubmed/20580800
Possible Intermolecular Interaction between Quinolones and Biphenylacetic Acid Inhibits y-Aminobutyric Acid Receptor Sites
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC284738/pdf/aac00374-0093.pdf
https://www.ncbi.nlm.nih.gov/pubmed/7840564
Fluoroquinolones Influence the intracellular calcium handling in individuals susceptible to malignant hyperthermia
http://onlinelibrary.wiley.com/doi/10.1002/mus.22021/full
https://www.ncbi.nlm.nih.gov/pubmed/21607983
Levofloxacin-induced Myasthenic Crisis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564188/
Levofloxacin-associated hypoglycaemia complicated by pontine myelinolysis and uadriplegia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613252/pdf/dme0025-0856.pdf
https://www.ncbi.nlm.nih.gov/pubmed/18644072
Levofloxacin-induced Achilles tendon rupture in a patient with systemic microscopic plyangiitis
https://www.ncbi.nlm.nih.gov/pubmed/17029067
https://link.springer.com/article/10.1007/s10165-005-0393-y
Peripheral sensory disturbances related to treatment with fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/8722551
https://pdfs.semanticscholar.org/4668/37688f8d0aad9843083a10c3398c883e92a5.pdf
Potential Interactions of the Extended-Spectrum Fluoroquinolones with the CNS
https://link.springer.com/article/10.2165/00002018-199921020-00005
Unexpected, severe central nerve system toxicity of ofloxacine: report of two cases
https://www.ncbi.nlm.nih.gov/pubmed/17268904
Risk of Severe Dysglycemia Among Diabetic Patients Receiving Levofloxacin, Ciprofloxacin, or Moxifloxacin in Taiwan
https://www.ncbi.nlm.nih.gov/pubmed/23948133
Safety issues and drug—drug interactions with commonly used quinolones
https://www.ncbi.nlm.nih.gov/pubmed/25423877
Synergistic effects of dexamethasone and quinolones on human-derived tendon cells
https://www.ncbi.nlm.nih.gov/pubmed/20034766
http://www.ijaaonline.com/article/S0924-8579(09)00483-X/fulltext
https://www.sciencedirect.com/science/article/abs/pii/S092485790900483X
The perils of prescribing fluoroquinolones http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true
https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf
The Safety Profile of the Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/10945507
Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
https://www.ncbi.nlm.nih.gov/pubmed/24410307
Convulsant and Subconvulsant Doses of Norfloxacin in the Presence and Absence of Biphenylacetic Acid Alter Extracellular Hippocampal Glutamate but Not Gamma-Aminobutyric Acid Levels in Conscious Rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127025/pdf/0301.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127025/
https://www.ncbi.nlm.nih.gov/pubmed/11796360
Enhanced susceptibility of pentylenetetrazole kindled mice to quinolone effects
https://www.ncbi.nlm.nih.gov/pubmed/10461842
https://www.sciencedirect.com/science/article/pii/S0924857999000679
Evaluation of the Possible Epileptogenic Activity of Ciprofloxacin: The Role of Nigella sativa on Amino Acids Neurotransmitters
https://www.ncbi.nlm.nih.gov/pubmed/23086472
Hepatocytes-the choice to investigate drug metabolism and toxicity in man: In Vitro variability as a reflection of in vivo
https://www.ncbi.nlm.nih.gov/pubmed/17134688
Hippocampal Activity in the Presence of Quinolones and fenbufen in-vitro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC284301/pdf/aac00376-0152.pdf
https://www.ncbi.nlm.nih.gov/pubmed/1929256
Pharmacokinetic Pharmacokinetic drug‑drug interaction and their implication in clinical management
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897029/
https://www.ncbi.nlm.nih.gov/pubmed/24516494
Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes
https://www.nature.com/articles/aps2008184.pdf
https://www.ncbi.nlm.nih.gov/pubmed/19026171
Effect of fluoroquinolones for Anticonvulsant activities on PTZ induced seizures in mice
http://www.journalijar.com/uploads/2013-11-01_111226_981.pdf
A pharmacokinetic-pharmacodynamic approach to show that not all fluoroquinolones exhibit similar sensitivity toward the proconvulsant effect of biphenyl acetic acid in rats
https://www.ncbi.nlm.nih.gov/pubmed/11733465
https://academic.oup.com/jac/article/48/6/813/743793
Adverse Reactions to Fluoroquinolones. An Overview on Mechanistic Aspects
https://www.ncbi.nlm.nih.gov/pubmed/11172695
Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect – comprehensive overview of clinical trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785617/pdf/40360_2016_Article_53.pdf
https://www.ncbi.nlm.nih.gov/pubmed/26960809
Effect of Bile Duct Ligation and Unilateral Nephrectomy on Brain Concentration and Convulsant Potential of the Quinolone Antibacterial Agent Levofloxacin in Rats
https://academic.oup.com/toxsci/article-pdf/29/2/280/4593964/29-2-280.pdf
Peripheral neuropathy and Guillain-Barré syndrome risks associated with exposure to systemic fluoroquinolones: a pharmacovigilance analysis
https://www.ncbi.nlm.nih.gov/pubmed/24472364
https://www.sciencedirect.com/science/article/pii/S1047279713004754
Alteration of pharmacokinetics of cyclophosphamide and suppression of the cytochrome P450 genes by ciprofloxacin
https://www.nature.com/articles/1703815.pdf
https://www.ncbi.nlm.nih.gov/pubmed/12621481
Antimicrobial Safety: Focus on Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/15942881
https://academic.oup.com/cid/article/41/Supplement_2/S144/308000
Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf
https://www.ncbi.nlm.nih.gov/pubmed/26838075
Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human
https://www.ncbi.nlm.nih.gov/pubmed/8894516
https://www.ncbi.nlm.nih.gov/pubmed/26838075
The Quinolones, Ch 16, Prospects
https://www.sciencedirect.com/science/article/pii/B9780120595174500179
Fluoroquinolone Adverse Effects and Drug Interactions
http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full
https://www.ncbi.nlm.nih.gov/pubmed/11642691
Quinolone-induced Hypoglycemia: A Life-threatening but potentially reversible side effect
http://www.amjmed.com/article/S0002-9343(09)00871-7/pdf
https://www.amjmed.com/article/S0002-9343(09)00871-7/fulltext
Investigating effects of the antibiotic ciprofloxacin on the dopaminergic SH-SY5Y cell line
https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1275&context=masters_theses_2
DYSGLYCEMIA
FDA Warning and Study Highlight Fluoroquinolone Risks
https://jamanetwork.com/journals/jama/article-abstract/1737039?redirect=true
https://www.ncbi.nlm.nih.gov/pubmed/24026585
Possible involvement of DEC1 on the adverse effects of quinolone antibiotics
http://www.myquinstory.info/wp-content/uploads/2010/01/Shi-2010-DEC1.pdf
https://www.ncbi.nlm.nih.gov/pubmed/20214949
Comparative Risk of Serious Hypoglycemia among Persons Dispensed a Fluoroquinolone versus a Non-fluoroquinolone Antibiotic https://www.mdlinx.com/journal-summary/comparative-risk-of-serious-hypoglycemia-among-persons-dispensed-a-fluoroquinolone-vs-a-non/1vy8RCPhcgvuvcGY6WNWiK
ENDOCRINE
Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell Death Signaling and Reduces TNF Clearance in a Murine Model of Idiosyncratic Hepatotoxicity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742585/pdf/kfp163.pdf
https://www.ncbi.nlm.nih.gov/pubmed/19638433
The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203117/pdf/pone.0025637.pdf
https://www.ncbi.nlm.nih.gov/pubmed/22046243
The effect of levofloxacin and moxifloxacin on cardiovascular functions of rats with streptozotocin-induced diabetes
https://www.ncbi.nlm.nih.gov/pubmed/22621918
https://journals.sagepub.com/doi/abs/10.1177/1479164112445755
The insulinotropic effect of fluoroquinolones hypoglycemia
https://www.ncbi.nlm.nih.gov/pubmed/19073153
https://www.sciencedirect.com/science/article/pii/S000629520800854X
Gatifloxacin Induces S and G2-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via p21/p27/p53
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047796
ENVIRONMENTAL CONTAMINATION
Metal-mediated oxidation of fluoroquinolone antibiotics in water: Areview on kinetics, transformation products, and toxicity assessment
https://www.sciencedirect.com/science/article/pii/S0304389417306593
https://www.ncbi.nlm.nih.gov/pubmed/28919428
A one-step chemiluminescence immunoassay for 20 fluoroquinolone residues in fish and shrimp
based on a single chain Fv–alkaline phosphatase fusion protein
http://pubs.rsc.org/en/Content/ArticleLanding/2015/AY/c5ay01410g#!divAbstract
Preparation and characterization of molecularly imprinted monolithic column for on-line solid-phase extraction coupled with HPLC for determination of the fluoroquinolone residues in honey samples
http://www.tandfonline.com/doi/abs/10.1080/10826076.2011.649877
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170576/
Acute toxicity evaluation for quinolone antibiotics and their chlorination disinfection processes
https://www.ncbi.nlm.nih.gov/pubmed/25193832
Metal-mediated oxidation of fluoroquinolone antibiotics in water: A review on kinetics, transformation products, and toxicity assessment
https://www.sciencedirect.com/science/article/pii/S0304389417306593
https://www.ncbi.nlm.nih.gov/pubmed/28919428
Analysis of positions and substituents on genotoxicity of fluoroquinolones with quantitative structure-activity relationship and 3D Pharmacophore model
https://www.ncbi.nlm.nih.gov/pubmed/27835744
https://www.sciencedirect.com/science/article/pii/S0147651316304493
Antibiotics Threaten Wildlife: Circulating Quinolone Residues and Disease in Avian Scavengers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186382/
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001444
Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test
https://hal.archives-ouvertes.fr/hal-01191262/document
https://www.ncbi.nlm.nih.gov/pubmed/22047769
Chemiluminescence competitive indirect enzyme immunoassay for 20 fluoroquinolone
https://www.ncbi.nlm.nih.gov/pubmed/23842902
https://link.springer.com/article/10.1007%2Fs00216-013-7174-9
Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma–Dependent Liver Injury
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638649/pdf/kfn205.pdf
Determination of fluoroquinolone antibiotic residues in the plasma of Eurasian griffon vultures (Gyps fulvus) in Spain
https://www.ncbi.nlm.nih.gov/pubmed/27037883
https://www.sciencedirect.com/science/article/pii/S004896971630506X
High-resolution mass spectrometry applied to the identification of transformation products of quinolones from stability studies and new metabolites of enrofloxacin in chicken muscle tissues
http://diposit.ub.edu/dspace/bitstream/2445/50423/1/633709.pdf
Levofloxacin residues in chicken meat and giblets
https://www.researchgate.net/publication/258990521_LEVOFLOXACIN_RESIDUES_IN_CHICKEN_MEAT_AND_GIBLETS
Oxidative transformation of levofloxacin by d-MnO2: Products, pathways and toxicity assessment
https://www.ncbi.nlm.nih.gov/pubmed/25036942
https://www.sciencedirect.com/science/article/pii/S004565351400811X?via%3Dihub
Electrochemical oxidation of fluoroquinolone antibiotics: Mechanism, residual antibacterial activity and toxicity change
Quinolone Antibiotics Induce Shiga Toxin–Encoding Bacteriophages, Toxin Production, and Death in Mice
https://www.ncbi.nlm.nih.gov/pubmed/10669353
Simultaneous Determination of the Residues of Fourteen Quinolones and Fluoroquinolones in Fish Samples using Liquid Chromatography with Photometric and Fluorescence Detection
http://www.agriculturejournals.cz/publicFiles/56594.pdf
Residue Depletion Study of Danofloxacin in Cultured Tilapia (Oreochromis mossambicus)
https://www.ncbi.nlm.nih.gov/pubmed/26025372
Screening of Antibiotic Residues in Poultry Liver, Kidney and Muscle in Khartoum State, Sudan
https://pdfs.semanticscholar.org/5640/556fcccf7260990ad15703928eab8db73058.pdf
Toxicological Assessment of Trace b-Diketone Antibiotic Mixtures on Zebrafish (Danio rerio) by Proteomic Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111491/pdf/pone.0102731.pdf
Wildlife contamination with fluoroquinolones from livestock: Widespread occurrence of enrofloxacin and marbofloxacin in vultures
https://www.ncbi.nlm.nih.gov/pubmed/26498102
Increasing toxicity of enrofloxacin over four generations of Daphnia Magna
https://www.ncbi.nlm.nih.gov/pubmed/27379980
Pharmacokinetic and residue studies of quinolone compounds and olaquindox in poultry
https://hal.archives-ouvertes.fr/hal-00902002/document
Rapid Depletion of Marbofloxacin Residues in Rabbit after Therapeutic Treatment
http://jfoodprotection.org/doi/pdf/10.4315/0362-028X-68.11.2480
Effects and Interactions in an Environmentally Relevant Mixture of Pharmaceuticals
https://www.ncbi.nlm.nih.gov/pubmed/18048368
Fluoroquinolone resistance in the external environment and the human gut
Comparison of plasma and tissue disposition of enrofloxacin in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio) after a single oral Administration
https://www.ncbi.nlm.nih.gov/pubmed/25372241
Concentrations of Antibiotic Residues Vary between Different Edible Muscle Tissues in Poultry
http://jfoodprotection.org/doi/pdf/10.4315/0362-028X-68.10.2217?code=fopr-site
Development of a Monoclonal Antibody-Based Broad-Specificity ELISA for Fluoroquinolone
Antibiotics in Foods and Molecular Modeling Studies of Cross-Reactive Compounds
https://www.ncbi.nlm.nih.gov/pubmed/17511422
Engineering of a broad-specificity antibody: Detection of eight fluoroquinolone antibiotics simultaneously
https://www.ncbi.nlm.nih.gov/pubmed/20920457
Concerns about extralabel fluoroquinolone use in food-producing animals
https://avmajournals.avma.org/doi/pdf/10.2460/javma.243.9.1242
FQ and Metabolites in Chicken Muscles using MS-MS Barcelona Spain
http://diposit.ub.edu/dspace/bitstream/2445/50423/1/633709.pdf
FARMING / FOOD SUPPLY
Confirmation of fluoroquinolone residues in salmon
https://www.fda.gov/downloads/Food/FoodScienceResearch/ucm071507.pdf
FDA FQ residue
Levofloxacin residues in chicken meat and giblets
https://www.researchgate.net/publication/258990521_LEVOFLOXACIN_RESIDUES_IN_CHICKEN_MEAT_AND_GIBLETS
FLUOROQUINOLONES
Concurrent Determination of Four Fluoroquinolones; Ciprofloxacin, Enrofloxacin,
Sarafloxacin and Difloxacin in Atlantic Salmon Tissue by LC with Fluorescence Detection
https://www.ncbi.nlm.nih.gov/pubmed/12477191
Screening of Antibiotic Residues in Poultry Liver, Kidney and Muscle in Khartoum State, Sudan
https://pdfs.semanticscholar.org/5640/556fcccf7260990ad15703928eab8db73058.pdf
An Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo
https://www.ncbi.nlm.nih.gov/pubmed/18829036
The Toxicologist ISSN 1096-6080 Volume 108, Number 1, March 2009 Supplement to Toxicological Sciences
https://www.toxicology.org/pubs/docs/Tox/2009Tox.pdf
FLUOROQUINOLONE ADR'S
Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma–Dependent Liver Injury
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2638649/pdf/kfn205.pdf
Treatment of the Fluoroquinolone Associated Disability –
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf
https://www.hindawi.com/journals/omcl/2017/8023935/
Fluoroquinolones-Associated Disability: It Is Not All in Your Head
https://www.mdpi.com/2673-4087/2/3/17/htm
A New Criterion for Fluoroquinolone-Associated Disability Diagnosis: Functional Gastrointestinal Disorders https://www.mdpi.com/1648-9144/57/12/1371
Fluoroquinolone antibiotics and adverse events https://www.nps.org.au/australian-prescriber/articles/fluoroquinolone-antibiotics-and-adverse-events?fbclid=IwAR08oCisVnsxi28yEtqI93VFKplxmn9ujefwgufKaKjEt3IDTB8c7E9_VEs
FLUOROQUINOLONE ANTIBODIES
Development of an immunoaffinity column method using broad-specificity monoclonal antibodies for simultaneous extraction and cleanup of quinolone and sulfonamide antibiotics in animal muscle tissues
https://www.ncbi.nlm.nih.gov/pubmed/18823896
An Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo
FLUOROQUINOLONE DEGRADATION
Evaluation and degradation Chemistry of Orbifloxacin using LC-MS
FLUOROQUINOLONE ORGANIC COMPOUNDS
7-{4-[(1,3-Benzodioxol-5-yl) methyl]-piperazin-1-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394047/pdf/e-68-o2264.pdf
A Convergent Synthetic Route to (+)-Dynemicin A and Analogs of Wide Structural Variability
http://pubs.acs.org/doi/abs/10.1021/ja9703741
A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles
GASTROINTESTINAL
Adverse Drug Reactions Related to the Use of Fluoroquinolone Antimicrobials An Analysis of Spontaneous Reports and Fluoroquinolone Consumption Data from Three Italian Regions
Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-b1 secretion and enhances the anti-proliferative effect of 5-fluorouracil
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707983/pdf/bph0157-0362.pdf
Safety issues and drug—drug interactions with commonly used quinolones
https://www.ncbi.nlm.nih.gov/pubmed/25423877
The perils of prescribing fluoroquinolones
https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf
Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles
https://www.ncbi.nlm.nih.gov/pubmed/24410307
Mechanistic Study on Flumequine Hepatocarcinogenicity Focusing on DNA Damage in Mice
https://academic.oup.com/toxsci/article/69/2/317/1679679
https://www.ncbi.nlm.nih.gov/pubmed/12377980
The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203117/pdf/pone.0025637.pdf
Effect of Fluoroquinolone Treatment on Growth of and Toxin Production by Epidemic and Nonepidemic Clostridium difficile Strains in the Cecal Contents of Mice_
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1932513/pdf/1582-06.pdf
Fluoroquinolone Adverse Effects and Drug Interactions
http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full
https://www.ncbi.nlm.nih.gov/pubmed/11642691
A New Criterion for Fluoroquinolone-Associated Disability Diagnosis: Functional Gastrointestinal Disorders https://www.mdpi.com/1648-9144/57/12/1371
GENITOURINARY
Mechanistic Study on Flumequine Hepatocarcinogenicity Focusing on DNA Damage in Mice
GENOTOXICITY
DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes
https://www.ncbi.nlm.nih.gov/pubmed/19122895
Topoisomerase II inhibition involves characteristic chromosomal expression patterns
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488358/pdf/1471-2164-9-324.pdf
Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro
http://www.nmcth.edu/images/gallery/Editorial/xRZVmps_ambulkar.pdf
4-Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes In Vitro
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf
A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods
Investigating effects of the antibiotic ciprofloxacin on the dopaminergic SH-SY5Y cell line
https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1275&context=masters_theses_2
Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells
https://www.ncbi.nlm.nih.gov/pubmed/26205818
Analysis of positions and substituents on genotoxicity of fluoroquinolones with quantitative structure-activity relationship and 3D Pharmacophore model
https://www.ncbi.nlm.nih.gov/pubmed/27835744
Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment
of bacterial infections: a puzzling paradox or a logical consequence of their mode of action?
https://www.ncbi.nlm.nih.gov/pubmed/25515946
Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the
Vicia faba micronucleus test
https://hal.archives-ouvertes.fr/hal-01191262/document
Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors
https://www.ncbi.nlm.nih.gov/pubmed/9748648
Copper(II) complexes with norfloxacin and neutral terpyridines: Cytotoxic, antibacterial, superoxide dismutase and DNA-interaction approach
https://www.sciencedirect.com/science/article/pii/S0277538712002112
Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791872/pdf/bsr033e072.pdf
Ciprofloxacin: mammalian DNA topoisomerase type II poison in vivo
https://www.sciencedirect.com/science/article/pii/016579929390029U
https://www.ncbi.nlm.nih.gov/pubmed/7678175
Clinical toxicological aspects of fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/12052667
Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells
https://www.ncbi.nlm.nih.gov/pubmed/23813946
Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in Ciprofloxacin-Treated Mammalian Cells
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.972.1373&rep=rep1&type=pdf
http://molpharm.aspetjournals.org/content/50/5/1178.long
https://www.ncbi.nlm.nih.gov/pubmed/8913349
Compare two methods of measuring DNA damage induced by photogenotoxicity of fluoroquinolones
http://www.chinaphar.com/article/view/7857/8443
DNA topoisomerases in mtDNA maintenance and ageing
https://www.ncbi.nlm.nih.gov/pubmed/24440386
Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg2+ to the second metal binding site
http://www.sciencedirect.com/science/article/pii/S030441651500358X
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720527/pdf/nihms749655.pdf
Genotoxic Evaluation of the Antibacterial Drug, Ciprofloxacin, in Cultured Lymphocytes of Patients with Urinary Tract Infection
http://journals.tubitak.gov.tr/medical/issues/sag-04-34-5/sag-34-5-4-0401-1.pdf
Genotoxic potential of quinolone antimicrobials in the in vitro comet assay and micronucleus test
https://www.ncbi.nlm.nih.gov/pubmed/16384725
https://www.sciencedirect.com/science/article/pii/S1383571805002846
Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective
https://www.ncbi.nlm.nih.gov/pubmed/18840496
In vitro induction of micronuclei and chromosome aberrations by quinolones: possible mechanisms
https://www.ncbi.nlm.nih.gov/pubmed/8676903
Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity
https://www.ncbi.nlm.nih.gov/pubmed/12840108
Several gene programs are induced in ciprofloxacin-treated human lymphocytes as revealed by microarray analysis
https://www.ncbi.nlm.nih.gov/pubmed/12949250
DNA Gyrase and the supercoiling of DNA
https://www.ncbi.nlm.nih.gov/pubmed/6243420
DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC146802/pdf/252716.pdf
DNA Gyrase-mediated Wrapping of the DNA Strand Is Required for the Replication Fork Arrest by the DNA Gyrase-Quinolone-DNA Ternary Complex
http://www.jbc.org/content/275/44/34780.full.pdf
DNA Strand Cleavage Is Required for Replication Fork Arrest by a Frozen Topoisomerase-Quinolone-DNA Ternary Complex
http://www.jbc.org/content/271/42/26424.full.pdf
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
https://www.sciencedirect.com/science/article/pii/S1074552110001614?via%3Dihub
Study for genotoxicity and carcinogenicity of quinolone antimicrobials in mammals
Evaluating the genotoxicity of topoisomerase-targeted antibiotics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331794/pdf/ger089.pdf
Evaluation of photodegradation, phototoxicity and photogenotoxicity of ofloxacin in ointments with sunscreens and in solutions
https://www.ncbi.nlm.nih.gov/pubmed/25728226
https://www.sciencedirect.com/science/article/pii/S101113441500041X
Inhibition of Human Topoisomerase II_ by Fluoroquinolones and Ultraviolet A Irradiation
https://academic.oup.com/toxsci/article/69/1/16/1707336
Relationship of cellular topoisomerase II a inhibition to cytotoxicity and published genotoxicity of fluoroquinolone antibiotics in V79 cells
https://www.sciencedirect.com/science/article/pii/S0009279713000057
Importance of the Fourth Alpha-Helix within the CAP Homology Domain of Type II Topoisomerase for DNA Cleavage Site Recognition and Quinolone Action
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127396/pdf/0027.pdf
Characterization of ciprofloxacin binding to the linear single- and double-stranded DNA
https://www.ncbi.nlm.nih.gov/pubmed/12890558
Chromosomal Aberrations and Genomic Instability Induced by Topoisomerase-Targeted Antitumour Drugs
https://www.ncbi.nlm.nih.gov/pubmed/15281904
Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.878.6133&rep=rep1&type=pdf
Inhibitory Effects of Quinolones on Pro- and Eucaryotic DNA Topoisomerases I and II
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC171971/pdf/aac00066-0125.pdf
Ofloxacin induces oxidative damage to joint chondrocytes of juvenile rabbits: Excessive production of reactive oxygen species, lipid peroxidation and DNA damage
https://www.ncbi.nlm.nih.gov/pubmed/19818344
Characterization of Abcc4 Gene Amplification in Stepwise-Selected Mouse J774 Macrophages Resistant to the Topoisomerase II Inhibitor Ciprofloxacin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230599/pdf/pone.0028368.pdf
Photogenotoxicity of Fluoroquinolones in Chinese Hamster V79 Cells: Dependency on Active Topoisomerase II
https://www.ncbi.nlm.nih.gov/pubmed/10089819
Photosensitization Reactions of Fluoroquinolones and Their Biological Consequences
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.00978.x/full
https://www.ncbi.nlm.nih.gov/pubmed/21770950
Photosensitized DNA Damage; The Case of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/19320842
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2009.00548.x/abstract
Photosensitizing Mechanism and Identification of Levofloxacin Photoproducts at Ambient UV Radiation
https://www.ncbi.nlm.nih.gov/pubmed/22211524
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01068.x/abstract
Ciprofloxacin inhibits proliferation and promotes generation of aneuploidy in jurkat cells
http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf
Cytogenetic alterations in human lymphocyte cultures following exposure to ofloxacin
http://www.tandfonline.com/doi/full/10.1080/01480545.2016.1188305
https://www.ncbi.nlm.nih.gov/pubmed/27240646
Ofloxacin induces oxidative damage to joint chndrocytes of juvenile rabbits. Excessive
https://www.ncbi.nlm.nih.gov/pubmed/19818344
Inhibitory Effects of Quinolones on Pro- and Eucaryotic DNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC171971/pdf/aac00066-0125.pdf
Chromosomal aberrations and genomic instability induced by topoisomerase-targeted antitumour drugs
https://pubmed.ncbi.nlm.nih.gov/15281904/
Characterization of ciprofloxacin binding to the linear
https://www.ncbi.nlm.nih.gov/pubmed/12890558
Importance of the Fourth Alpha-Helix within the CAP Homology
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127396/pdf/0027.pdf
Relationship of cellular topoisomerase II a inhibition to cytotoxicity
https://www.sciencedirect.com/science/article/pii/S0009279713000057
Inhibition of Human Topoisomerase II by Fluoroquinolones and Ultraviolet A Irradiation
https://academic.oup.com/toxsci/article/69/1/16/1707336
Evaluation of photodegradation, phototoxicity and photogenotoxicity
https://www.ncbi.nlm.nih.gov/pubmed/25728226
https://www.sciencedirect.com/science/article/pii/S101113441500041X
Evaluating the genotoxicity of topoisomerasetargeted
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331794/pdf/ger089.pdf
Several gene programs are induced in ciprofloxacin-treated
https://www.ncbi.nlm.nih.gov/pubmed/12949250
Investigations into the concept of a threshold for topoisomerase inhibitor‐induced clastogenicity
https://academic.oup.com/mutage/article/18/4/345/1079374
In Vitro induction of micronuclei and chromosome aberrations by quinolones possible
https://www.ncbi.nlm.nih.gov/pubmed/8676903
Genotoxicity of topoisomerase II inhibitors An anti-infective perspective
https://www.ncbi.nlm.nih.gov/pubmed/18840496
Genotoxic potential of quinolone antimicrobials in the in vitro comet assay and
https://www.ncbi.nlm.nih.gov/pubmed/16384725
https://www.sciencedirect.com/science/article/pii/S1383571805002846
Genotoxic Evaluation of the Antibacterial Drug
http://journals.tubitak.gov.tr/medical/issues/sag-04-34-5/sag-34-5-4-0401-1.pdf
Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase
http://www.sciencedirect.com/science/article/pii/S030441651500358X
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720527/pdf/nihms749655.pdf
DNA topoisomerases in mtDNA maintenance and ageing
https://www.ncbi.nlm.nih.gov/pubmed/24440386
DNA Damage from Phototoxicity of Quinolones
http://www.chinaphar.com/article/view/7857/8443
Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.972.1373&rep=rep1&type=pdf
Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.13364
Probabilistic Neural Network Multiple Classifier System for Predicting the Genotoxicity of Quinolone and Quinoline Derivatives
HEMATIC
Levofloxacin-Induced Autoimmune Hemolytic Anemia
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1004.1741&rep=rep1&type=pdf
https://www.ncbi.nlm.nih.gov/pubmed/12841809
HEPATIC
2D, 3D-QSAR and molecular
https://www.ncbi.nlm.nih.gov/pubmed/24185373
Topoisomerase II inhibition involves characteristic chromosomal
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488358/pdf/1471-2164-9-324.pdf
Acute abdalla master
http://www.tandfonline.com/doi/abs/10.3109/15569543.2015.1076483?src=recsys&journalCode=itxr20
Acyl Glucuronide DNA-adducts from Quinolones
https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf
Adverse Effects
http://www.asmscience.org/content/book/10.1128/9781555817817.chap25
Fluoroquinolone Adverse Effects and Drug Interactions
http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full
https://www.ncbi.nlm.nih.gov/pubmed/11642691
The Quinolones, Ch 16, Prospects
https://www.sciencedirect.com/science/article/pii/B9780120595174500179
Safety of fluoroquinolones update
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/pdf/JID13054.pdf
Chronic administration of caderofloxacin,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf
Antimicrobial Safety
Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742585/pdf/kfp163.pdf
Comparison of plasma and tissue disposition of
https://www.ncbi.nlm.nih.gov/pubmed/25372241
Ciprofloxacin-induced cholestatic liver injury - a case report
http://vestnik.szd.si/index.php/ZdravVest/article/view/797/677
Drug bioactivation and protein adduct formation in the pathogenesis of
Hepatocytes-the choice to investigate drug metabolism and toxicity in man
https://www.ncbi.nlm.nih.gov/pubmed/17134688
Cytotoxic effects and apoptosis induction of enrofloxacin in hepatic (1)
https://www.ncbi.nlm.nih.gov/pubmed/26475364
Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential
https://www.ncbi.nlm.nih.gov/pubmed/20655887
Trovafloxacin-Induced Gene Expression Changes in Liver-Derived
http://dmd.aspetjournals.org/content/dmd/36/2/223.full.pdf
Trovafloxacin Enhances Lipopolysaccharide-Stimulated
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056269/pdf/jpet.114.214189.pdf
Toxicol. Sci.-2002-Kashida-317-21
Third and Fourth Generation Fluoroquinolone
https://www.ncbi.nlm.nih.gov/pubmed/24410307
The Safety Profile of the Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/10945507
The perils of prescribing fluoroquinolones
The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglycaemic action
https://www.ncbi.nlm.nih.gov/pubmed/18706903
http://www.sciencedirect.com/science/article/pii/S0014299908008054?via%3Dihub
Study for genotoxicity and carcinogenicity of
Safety issues and drug—drug
https://www.ncbi.nlm.nih.gov/pubmed/25423877
Risk of hepatotoxicity associated with fluoroquinolones a national case-control
https://www.ncbi.nlm.nih.gov/pubmed/24352180
https://pdfs.semanticscholar.org/ad41/0ef510774fbf677a6f8c841716759452151a.pdf
http://digitalcommons.uri.edu/php_facpubs/28/
Risk of Acute Liver Injury Associated with the Use of Moxifloxacin and Other Oral Antimicrobials: A Retrospective, Population-Based Cohort Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260122/pdf/phar0034-0336.pdf
Mechanisms of trovafloxacin hepatotoxicity Studies
https://www.sciencedirect.com/science/article/pii/S0960894X07012498
https://www.ncbi.nlm.nih.gov/pubmed/17976985
Inhibitory effect of several fluoroquinolones on hepatic microsomal Cytochrome P-450
https://www.ncbi.nlm.nih.gov/pubmed/16343288
Drug-induced liver injury: Interactions between drug properties and host factors
https://www.ncbi.nlm.nih.gov/pubmed/25912521
Fluoroquinolone therapy and idiosyncratic acute liver
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470619/pdf/1841565.pdf
Liver enzyme induction and inhibition: implications for anaesthesia
HEPATOXICITY
Unexpected severe hepatotoxicity of ciprofloxacine
https://www.ncbi.nlm.nih.gov/pubmed/21314468
Risk of hepatotoxicity associated with fluoroquinolones: A national case–control safety study
https://academic.oup.com/ajhp/article-abstract/71/1/37/5110881?redirectedFrom=fulltext
American Journal of Case Reports | A Case of Levofloxacin-Induced Hepatotoxicity
HERG K+ Channell
Relationship of cellular topoisomerase II a inhibition to cytotoxicity
https://www.sciencedirect.com/science/article/pii/S0009279713000057
HYPOGLYCEMIA
Metal-mediated oxidation of fluoroquinolone
https://www.sciencedirect.com/science/article/pii/S0304389417306593
Quinolone-induced Hypoglycemia: A Life-threatening but Potentially Reversible Side Effect
http://www.amjmed.com/article/S0002-9343(09)00871-7/pdf
IMMUNE
4-Quinolone Drugs Affect Cell Cycle Progression and Function of
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf
Fluorinated 4-quinolones induce hyperproduction of interleukin 2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC287008/pdf/pnas00248-0298.pdf
Construction and sequencing analysis of scFv
Adverse Effects
http://www.asmscience.org/content/book/10.1128/9781555817817.chap25
Calcium Signals Are Affected by Ciprofloxacin as a Consequence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/pdf/1543-05.pdf
Ciprofloxacin mammalian DNA topoisomerase type II poison in vivo
https://www.sciencedirect.com/science/article/pii/016579929390029U
https://www.ncbi.nlm.nih.gov/pubmed/7678175
Uptake and Intracellular Activity of Trovafloxacin in Human
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163701/pdf/410274.pdf
High-Performance Liquid Chromatography Measurement of
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC175825/pdf/aac00102-0064.pdf
Gatifloxacin Induces S and G2-Phase Cell Cycle Arrest in Pancreatic Cancer Cells via p21/p27/p53
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047796
The Bile Acid Receptor GPBAR-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203117/pdf/pone.0025637.pdf
Quinolone-Induced Upregulation of Osteopontin Gene Promoter
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370769/pdf/zac2868.pdf
Development of a Monoclonal Antibody-Based
https://www.ncbi.nlm.nih.gov/pubmed/17511422
Ciprofloxacin Induces an Immunomodulatory Stress
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC105711/pdf/ac001923.pdf
Treatment of the Fluoroquinolone Associated Disability –
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf
https://www.hindawi.com/journals/omcl/2017/8023935/
Hypersensitivity reactions to fluoroquinolones analysis of the factors
https://www.ncbi.nlm.nih.gov/pubmed/23600547
Fluoroquinolone toxicity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981197/pdf/cp-2012-4-e87.pdf
Immunomodulatory Activities of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/16518713
http://www.academia.edu/5656193/Immunomodulatory_Activities_of_Fluoroquinolones
Cytogenetic alterations in human lymphocyte
http://www.tandfonline.com/doi/full/10.1080/01480545.2016.1188305
https://www.ncbi.nlm.nih.gov/pubmed/27240646
CIPROFLOXACIN INHIBITS PROLIFERATION AND PROMOTES
http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf
Several gene programs are induced in ciprofloxacin-treated
https://www.ncbi.nlm.nih.gov/pubmed/12949250
Mitochondria Reactive Oxygen T-Cells by Cipro
http://www.jimmunol.org/content/jimmunol/184/9/4827.full.pdf
Genotoxic Evaluation of the Antibacterial Drug
http://journals.tubitak.gov.tr/medical/issues/sag-04-34-5/sag-34-5-4-0401-1.pdf
Hypersensitivity reactions to fluoroquinolones
https://link.springer.com/article/10.1007/s11882-005-0049-1
INTERACTION WITH OTHER PATHOGENS
FDA Warning and Study Highlight
https://jamanetwork.com/journals/jama/article-abstract/1737039?redirect=true
Quinolone-induced Hypoglycemia A
http://www.amjmed.com/article/S0002-9343(09)00871-7/pdf
Fluoroquinolone Adverse Effects and Drug Interactions
http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full
https://www.ncbi.nlm.nih.gov/pubmed/11642691
The Quinolones, Ch 16, Prospects
https://www.sciencedirect.com/science/article/pii/B9780120595174500179
The insulinotropic effect of fluoroquinolones hypoglycemia
https://www.ncbi.nlm.nih.gov/pubmed/19073153
The effect of levofloxacin and moxifloxacin on cardiovascular
https://www.ncbi.nlm.nih.gov/pubmed/22621918
The Effect of Ciprofloxacin Injection on Genetically Absence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202555/pdf/BCN-4-031.pdf
Antibiotic-Induced Neurotoxicity
Third and Fourth Generation Fluoroquinolone
https://www.ncbi.nlm.nih.gov/pubmed/24410307
The perils of prescribing fluoroquinolones
https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf
Torsades de pointes fq
https://www.ncbi.nlm.nih.gov/pubmed/15001976
Risk of Severe Dysglycemia Among Diabetic
https://www.ncbi.nlm.nih.gov/pubmed/23948133
Prulifloxacin as a trigger of myasthenia gravis
https://fqresearch.org/pdf_files/Prulifloxacin_trigger_myasthenia_gravis.pdf
Outpatient Gatifloxacin Therapy
Levofloxacin-induced myasthenic crisis
http://www.jem-journal.com/article/S0736-4679(12)01199-7/abstract
https://www.ncbi.nlm.nih.gov/pubmed/23218195
Levofloxacin-induced crystal nephropathy
http://onlinelibrary.wiley.com/doi/10.1111/nep.12405/abstract
https://www.ncbi.nlm.nih.gov/pubmed/25900386
Levofloxacin-induced Achilles tendon rupture in a patient with systemic microscopic polyangiitis
https://www.ncbi.nlm.nih.gov/pubmed/17029067
https://link.springer.com/article/10.1007/s10165-005-0393-y
Levofloxacin-associated hypoglycaemia complicated by
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613252/pdf/dme0025-0856.pdf
Fluoroquinolones influence the intracellular calcium handling in individuals
http://onlinelibrary.wiley.com/doi/10.1002/mus.22021/full
Evaluation of the appropriate use of commonly prescribed fluoroquinolones and the
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410896/pdf/tcrm-11-639.pdf
Effect of fluoroquinolones on mitochondrial function in pancreatic beta
https://www.ncbi.nlm.nih.gov/pubmed/24284031
http://www.sciencedirect.com/science/article/pii/S0928098713004508?via%3Dihub
Fluoroquinolone-associated myasthenia gravis exacerbation: evaluation of postmarketing reports from the US FDA adverse event reporting system and a literature review
https://www.ncbi.nlm.nih.gov/pubmed/21879778
https://link.springer.com/article/10.2165/11593110-000000000-00000
IRON CHELATION
Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf
JOINTS
Pharmacokinetic Prediction of Levofloxacin Accumulation
KIDNEY DAMAGE
Ciporofloxocin cryslluina
LIMPHOCYTE
Pharmacokinetic Prediction of Levofloxacin Accumulation
MAGNESIUM
Comparative Evaluation of Cartilage
https://www.ncbi.nlm.nih.gov/pubmed/8923679
In Vitro Evidence for Effects of Magnesium Supplementation
MECHANISM OF BINDING
Copper(I) complexes with phosphine derived from sparfloxacin
https://pdfs.semanticscholar.org/6a63/20aca61f78c3fd30b16435e535ed44707560.pdf
http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract
METABOLIZATION
ACYL GLUCURONIDATION OF FLUOROQUINOLONE ANTIBIOTICS BY THE UDP-GLUCURONOSYLTRANSFERASE 1A SUBFAMILY IN HUMAN LIVER MICROSOMES
https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf
HIGH-RESOLUTION MASS SPECTROMETRY APPLIED TO THE IDENTIFICATION OF TRANSFORMATION PRODUCTS OF QUINOLONES
http://diposit.ub.edu/dspace/bitstream/2445/50423/1/633709.pdf
Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf
METAL COMPLEX
DNA interaction, in vitro antimicrobial and SOD-like activity of copper(II)
https://www.sciencedirect.com/science/article/pii/S0022328X11007388
Biological activities of some Fluoroquinolones-metal complexes
https://www.ajol.info/index.php/ijmbr/article/view/91824
Tandem mass spectrometric study of ciprofloxacin–polyethylene glycol
https://www.sciencedirect.com/science/article/pii/S1387380608002108
Copper(II) complexes with norfloxacin and neutral terpyridines: Cytotoxic, antibacterial, superoxide dismutase and DNA-interaction approach
https://www.sciencedirect.com/science/article/pii/S0277538712002112
MISCELLANEOUS
Amsacrine-promoted DNA cleavage site determinants
https://www.sciencedirect.com/science/article/pii/S0006295296005163
Oxidative degradation study on antimicrobial agent ciprofloxacin
https://www.ncbi.nlm.nih.gov/pubmed/25201488
https://www.sciencedirect.com/science/article/pii/S0045653514009874
Metabolism of-1,4-Dihydro-7trans3methoxy4methylamino
http://dmd.aspetjournals.org/content/37/3/594.long
http://dmd.aspetjournals.org/content/dmd/37/3/594.full.pdf
Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection
https://academic.oup.com/jac/article/51/5/1109/784308
https://www.ncbi.nlm.nih.gov/pubmed/12697644
Engineering of a broad-specificity antibody
https://www.ncbi.nlm.nih.gov/pubmed/20920457
Drug-drug interactions and QT prolongation as
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785617/pdf/40360_2016_Article_53.pdf
Breakage-Reunion Domain of Streptococcus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810434/pdf/pone.0000301.pdf
ZATT (ZNF451)–mediated resolution
https://www.ncbi.nlm.nih.gov/pubmed/28912134
The Effects of Levofloxacin on Testis Tissue
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819380/pdf/Cell-J-18-112.pdf
Effect of metal ions on some pharmacologically relevant interactions involving fluoroquinolones
The Structure of DNA-Bound Human Topoisomerase II Alpha:Conformational Mechanisms for Coordinating Inter-SubunitInteractions with DNA Cleavage
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584591/pdf/nihms397579.pdf
Quinolone Antibiotics Induce Shiga Toxin
https://www.ncbi.nlm.nih.gov/pubmed/10669353
https://academic.oup.com/jid/article/181/2/664/824154
The Effect of Some Fluoroquinolone Family Members
https://pdfs.semanticscholar.org/2439/2c5c31fdfcf55478b7c6e62234e1fed0560b.pdf
Mass spectrometic study of speciation in aluminium-fluoroquinolone solutions
https://www.ncbi.nlm.nih.gov/pubmed/22837440
http://journals.sagepub.com/doi/abs/10.1255/ejms.1183?journalCode=emsa
Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes
https://europepmc.org/article/PMC/PMC7929499
Do Fluoroquinolones Increase Risk for Pseudotumor Cerebri?
Association of Fluoroquinolone Prescribing Rates With Black Box Warnings from the US Food and Drug Administration https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786698?fbclid=IwAR1RWN9Gv1MXV_SL1N9FOXnTzxNOpW8Kcu-jMDlJNPYsxulApu_YShPQ1bM
Transferable mechanisms of quinolone resistance https://www.academia.edu/12425533/Transferable_mechanisms_of_quinolone_resistance?email_work_card=title
Ciprofloxacin and Levofloxacin as Potential Drugs in Genitourinary Cancer Treatment-The Effect of Dose-Response on 2D and 3D Cell Cultures https://www.docwirenews.com/gu-oncology-now/ciprofloxacin-and-levofloxacin-as-potential-drugs-in-genitourinary-cancer-treatment-the-effect-of-dose-response-on-2d-and-3d-cell-cultures/
Fluoroquinolones are a potent form of chemotherapy https://onlinelibrary.wiley.com/doi/abs/10.1111/cxo.13102
Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review
The Use of Systemic Fluoroquinolones Committee on Infectious Diseases
Top2a promotes the development of social behavior via PRC2 and H3K27me3
https://pubmed.ncbi.nlm.nih.gov/36417527
MITOCHONDRIA
2D, 3D-QSAR and molecular docking of 4(1H)-quinolones analogues with antimalarial activities
https://www.ncbi.nlm.nih.gov/pubmed/24185373
4-Quinolones Cause a Selective Loss of Mitochondria
https://www.ncbi.nlm.nih.gov/pubmed/8440750
Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes In Vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf
Effects of Topoisomerase II-Active Drugs in Mitochondria
http://grantome.com/grant/NIH/R01-GM047535-01A1
Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences
https://www.ncbi.nlm.nih.gov/pubmed/27771494
INVESTIGATING EFFECTS OF THE ANTIBIOTIC CIPROFLOXACIN ON THE DOPAMINERGIC SH-SY5Y CELL LINE
http://scholarworks.umass.edu/masters_theses_2/275/
2015 Effect of norfloxacin and moxifloxacin on melanin synthesis and
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf
Adverse Effects of Antimicrobials via Predictable or Idiosyncratic effects
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421593/pdf/zac4046.pdf
Calcium Signals Are Affected by Ciprofloxacin as a Consequence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/pdf/1543-05.pdf
Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections
https://www.ncbi.nlm.nih.gov/pubmed/25515946
Bactericidal Antibiotics Induce Mitochondrial Dysfunction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/pdf/nihms-509241.pdf
Butachlor induced dissipation of mitochondrial membrane potential
https://www.ncbi.nlm.nih.gov/pubmed/22884430
Boar spermatozoa successfully predict mitochondrial modes of toxicity
https://www.ncbi.nlm.nih.gov/pubmed/25624015
Comparative Evaluation of Cartilage
https://www.ncbi.nlm.nih.gov/pubmed/8923679
Quinolones Action and Resistance Updated
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182077/pdf/CTMC-9-981.pdf
Pro-apoptotic effect of new quinolone
https://www.sciencedirect.com/science/article/pii/S0887233316300285
https://www.ncbi.nlm.nih.gov/pubmed/26916084
Interaction between quinolones antibiotics and bacterial outer membrane porin OmpF
https://www.ncbi.nlm.nih.gov/pubmed/15617818
Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
http://www.sciencedirect.com/science/article/pii/S0301008215300605?via%3Dihub
https://www.ncbi.nlm.nih.gov/pubmed/26603930?dopt=AbstractPlus
Treatment of the Fluoroquinolone Associated Disability
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf
https://www.hindawi.com/journals/omcl/2017/8023935/
Copper complexes with phosphine derived
http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract
Cytotoxic effects and apoptosis induction of enrofloxacin in hepatic
https://www.ncbi.nlm.nih.gov/pubmed/26475364
Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential
https://www.ncbi.nlm.nih.gov/pubmed/20655887
Trovafloxacin-Induced Gene Expression Changes in Liver-Derived
http://dmd.aspetjournals.org/content/dmd/36/2/223.full.pdf
The Role of Mitochondria in Brain Aging and the Effects of Melatonin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001212/pdf/CN-8-182.pdf
The perils of prescribing fluoroquinolones
https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf
The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglycaemic action
https://www.ncbi.nlm.nih.gov/pubmed/18706903
http://www.sciencedirect.com/science/article/pii/S0014299908008054?via%3Dihub
The effect of ciprofloxacin on sperm DNA damage, fertility potential and early embryonic development in NMRI mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312808/pdf/vrf-3-131.pdf
Quinolone-induced arthropathy an update focusing on new mechanistic and clinical data
https://www.ncbi.nlm.nih.gov/pubmed/18835137
https://www.sciencedirect.com/science/article/pii/S0924857908003531
CIPROFLOXACIN INHIBITS PROLIFERATION AND PROMOTES GENERATION OF ANEUPLOIDY IN JURKAT CELLS
http://jpp.krakow.pl/journal/archive/04_10/pdf/233_04_10_article.pdf
Photosensitizing Mechanism and Identification of Levofloxacin Photoproducts at Ambient UV Radiation
https://www.ncbi.nlm.nih.gov/pubmed/22211524
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01068.x/abstract
Photosensitization Reactions of Fluoroquinolones and Their Biological Consequences
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.00978.x/full
https://www.ncbi.nlm.nih.gov/pubmed/21770950
Ofloxacin induces oxidative damage to joint chondrocytes of juvenile rabbits
https://www.ncbi.nlm.nih.gov/pubmed/19818344
Ofloxacin induces apoptosis in microencapsulated juvenile rabbit
https://www.ncbi.nlm.nih.gov/pubmed/17961619
Musculoskeletal Complications of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/21333952
Lysosomal Membrane Permeabilization Induces Cell Death
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193790/pdf/20021952.pdf
Fluoroquinolones influence the intracellular calcium handling in individuals
http://onlinelibrary.wiley.com/doi/10.1002/mus.22021/full
In vitro study of cytotoxicity of quinolones on rabbit tenocytes
https://link.springer.com/article/10.1023/A:1007435025616
Fluoroquinolone Induced Tendinopathy
https://www.jstage.jst.go.jp/article/tjem/226/4/226_4_251/_pdf
Features of the ultrastructure of loach embryos under the influence of norfloxacin
https://link.springer.com/article/10.1007/s11956-008-2005-1
Evaluation of gatifloxacin for eye
https://www.ncbi.nlm.nih.gov/pubmed/25028261
http://journals.sagepub.com/doi/abs/10.1177/0960327114530743
Fluoroquinolone-induced serious, persistent, multisymptom adverse effects
http://www.dougbremner.com/FQ_Golomb.pdf
Effect of norfloxacin and moxifloxacin on melanin synthesis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf
Effect of fluoroquinolones on mitochondrial function in pancreatic beta
https://www.ncbi.nlm.nih.gov/pubmed/24284031
http://www.sciencedirect.com/science/article/pii/S0928098713004508?via%3Dihub
Drug induced liver injury Interactions between drug properties
https://www.ncbi.nlm.nih.gov/pubmed/25912521
Role of Mitochondria in Ciprofloxacin Sperm Cells
http://eprints.umsu.ac.ir/786/1/1933719113477482.pdf
The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells
https://www.ncbi.nlm.nih.gov/pubmed/19235604
Mitochondria Reactive Oxygen T-Cells by Cipro
http://www.jimmunol.org/content/jimmunol/184/9/4827.full.pdf
Influence on Mitochondria and Cytotoxicity of Different Antibiotics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797653/pdf/0729-05.pdf
In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon
http://jpet.aspetjournals.org/content/jpet/308/1/394.full.pdf
High-Content Screening for Compounds That Affect mtDNA-Encoded Protein
https://www.ncbi.nlm.nih.gov/pubmed/20625181
Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective
https://www.ncbi.nlm.nih.gov/pubmed/18840496
Gene expression profiles in the articular cartilage of juvenile rats receiving the
https://www.ncbi.nlm.nih.gov/pubmed/18572299
Fluoroquinolone-related neuropsychiatric
https://www.ncbi.nlm.nih.gov/pubmed/26955658
Effect of levofloxacin on glycosaminoglycan and DNA synthesis of cultured rabbit
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.845.2627&rep=rep1&type=pdf
Effect of ciprofloxacin and levofloxacin on some oxidative stress parameters in brain regions of male albino rats
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.893.9513&rep=rep1&type=pdf
DNA topoisomerases in mtDNA maintenance and ageing
https://www.ncbi.nlm.nih.gov/pubmed/24440386
Delayed Cytotoxicity and Cleavage of Mitochondrial DNA in Ciprofloxacin-treated Mammilian Cells
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.972.1373&rep=rep1&type=pdf
Damage to mitochondrial DNA induced by the quinolone Bay y 3118 in embryonic turkey liver
https://www.ncbi.nlm.nih.gov/pubmed/10216214
Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones
https://www.sciencedirect.com/science/article/pii/S1011134400001019
MITOCHONDRIAL DAMAGE CONSEQUENCES
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes
http://www.cell.com/cancer-cell/pdf/S1535-6108(06)00372-2.pdf
Acute metabolic amplification of insulin secretion in mouse islets is mediated by
https://www.ncbi.nlm.nih.gov/pubmed/23790612
https://www.sciencedirect.com/science/article/pii/S0026049513001479
Alternative Mitochondrial Electron Transfer for the Treatment of Neurodegenerative Diseases
https://www.ncbi.nlm.nih.gov/pubmed/26603930
Automated Spectrophotometric Analysis of Mitochondrial Respiratory Chain Complex
http://clinchem.aaccjnls.org/content/clinchem/51/11/2110.full.pdf
Avermectin Confers Its Cytotoxic Effects by Inducing DNA Damage
https://www.ncbi.nlm.nih.gov/pubmed/27551889
Causes of Death in Adults with Mitochondrial Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864865/pdf/978-3-662-49833-0_Chapter_449.pdf
Chronic fatigue syndrome and mitochondrial dysfunction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680051/pdf/ijcem0001-0001.pdf
Ciprofloxacin-induced cholestatic liver injury - a case report
http://vestnik.szd.si/index.php/ZdravVest/article/view/797/677
The Maintenance of Mitochondrial DNA Integrity—Critical Analysis and Update
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632056/pdf/cshperspect-DAM-a012641.pdf
DNA topoisomerases in mtDNA maintenance and ageing
https://www.ncbi.nlm.nih.gov/pubmed/24440386
https://www.sciencedirect.com/science/article/pii/S0531556514000126?via%3Dihub
Medication induced mitochondrial damage and disease
https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.200700075
Fluoroquinolone-related neuropsychiatric and mitochondrial toxicity: a collaborative
https://www.ncbi.nlm.nih.gov/pubmed/26955658
Hypoxic Pulmonary Vasoconstriction From Molecular Mechanisms to Medicine
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310129/pdf/main.pdf
In Vivo Inhibition of Trypanosome Mitochondrial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC359115/pdf/molcellb00009-0287.pdf
Increased prevalence of malignancy in adult mitochondrial disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034300/pdf/JMedLife-06-477.pdf
Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis
https://www.sciencedirect.com/science/article/pii/S016801021102061X
Methods to Study Mitochondrial Structure & Function
https://link.springer.com/chapter/10.1007/978-1-4614-4599-9_2
Mitochondrial abnormalities A link to idiosyncratic drug hepatotoxicity
https://www.ncbi.nlm.nih.gov/pubmed/17275868
Mitochondrial Disorders - Medicines to Avoid
http://www.medsafe.govt.nz/profs/PUArticles/June2017/MitochondrialDisordersMedicinestoAvoid.htm
Mitochondrial DNA Damage and its Consequences for Mitochondrial Gene Expression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412069/pdf/nihms388439.pdf
Mitochondrial DNA damage induced autophagy, cell death
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750375/pdf/nihms756435.pdf
Mitochondrial DNA damage
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818501/pdf/12933_2016_Article_372.pdf
Mitochondrial DNA exhibits resistance to induced
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062989/pdf/gkw716.pdf
MITOCHONDRIAL DNA HAPLOGROUP-DEPENDENCE OF DRUGS AND XENOBIOTICS TOXICITY
http://paduaresearch.cab.unipd.it/6619/1/Tesi_dottorato_Daniela_Strobbe.pdf
Mitochondrial Dysfunction and Chronic Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566449/pdf/35-43.pdf
Mitochondrial dysfunction and oxidative stress in aging and cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216692/pdf/oncotarget-07-44879.pdf
Mitochondrial dysfunction in aging Much progress but many
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580208/pdf/main.pdf
Mitochondrial dysfunction in cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844930/pdf/fonc-03-00292.pdf
Mitochondrial Dysfunction in Chemotherapy-Induced
http://www.mdpi.com/2305-6304/3/2/198/htm
Mitochondrial Reactive Oxygen Species Control T Cell Activation by Regulating IL-2 and IL-4 Expression Mechanism of Ciprofloxacin-Mediated Immunosuppression
http://www.jimmunol.org/content/jimmunol/184/9/4827.full.pdf
MITOCHONDRIAL TESTS
http://www.dr-forsyth.com/Dr_Charles_Forsyth/Downloads_files/MITOCHONDRIAL%20TESTS.pdf
Mitochondrial DNA Rearrangements in Health and Disease—A Comprehensive Study
https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.22452
The In Depth Evaluation of Suspected Mitochondrial Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810849/pdf/nihms49523.pdf
Analysis of mitochondrial dynamics and functions using imaging approaches
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007120/pdf/nihms234287.pdf
Nonalcoholic fatty liver disease and mitochondrial dysfunction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675113/pdf/WJG-14-193.pdf
Non-alcoholic fatty liver disease. From insulin resistance to mitochondrial dysfunction
http://www.grupoaran.com/mrmUpdate/lecturaPDFfromXML.asp?IdArt=458456&TO=RVN&Eng=0
Oxidatative stress-induced mitochondrial dysfunction drives inflammation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559140/?report=printable
Patterns of Mitochondrial DNA Damage in Blood
https://www.karger.com/Article/FullText/339207
Problems in Mitochondrial DNA forensics
http://www.tandfonline.com/doi/abs/10.1080/24701394.2017.1310853?journalCode=imdn21
Psychiatric symptoms of patients with primary mitochondrial DNA disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348039/pdf/1744-9081-8-9.pdf
Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War illness
http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184832&type=printable
THE EFFECT OF BACTERIAL DNA GYRASE INHIBITORS ON DNA SYNTHESIS IN MAMMILIAN MITOCHONDRIA
http://www.myquinstory.info/wp-content/uploads/2010/01/Castora-DNA-Synthesis-In-mam-mtDNA-1983.pdf
The other, forgotten genome: mitochondrial DNA and mental disorders
https://www.ncbi.nlm.nih.gov/pubmed/11673790
The Psychiatric Presentation of Mitochondrial Disorders in Adults
https://neuro.psychiatryonline.org/doi/pdf/10.1176/appi.neuropsych.11110345
The Role of Mitochondria in Brain Aging and the Effects of Melatonin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001212/pdf/CN-8-182.pdf
The Maintenance of Mitochondrial DNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632056/pdf/cshperspect-DAM-a012641.pdf
Effects of fluoroquinolones and tetracyclines on mitochondria of human retinal MIO-M1 cells https://www.sciencedirect.com/science/article/pii/S0014483521004231
MITOCHONDRIAL TOXICITY
Fluoroquinolone antibiotics and possible mitochondrial toxicity
https://www.sciencedirect.com/science/article/pii/S1567724915001506?via%3Dihub
Pathogenesis of quinolone-induced arthropathy: a review of hypotheses
https://www.ncbi.nlm.nih.gov/pubmed/15633793
Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010342/pdf/aps2011158a.pdf
Moxifloxacin and ciprofloxacin inducesS-phase arrest and augments apoptoticeffects of cisplatin in human pancreaticcancer cells via ERK activation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531397/pdf/12885_2015_Article_1560.pdf
Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820800/pdf/aps2015160a.pdf
Trimethoxy-benzaldehyde levofloxacin hydrazoneinducing the growth arrest and apoptosis ofhuman hepatocarcinoma cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716872/pdf/1475-2867-13-67.pdf
MOLECULAR STRUCTURE
Discovery of Fluoroquinolone derivatives as potent, selective inhibitors of PI3Kγ
http://pubs.rsc.org/en/content/articlelanding/md/2015/c5md00364d#!divAbstract
Copper(I) complexes with phosphine derived
https://pdfs.semanticscholar.org/6a63/20aca61f78c3fd30b16435e535ed44707560.pdf
http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract
MUSCLE
Fluoroquinolones and Musculoskeletal Toxicity In Pediatrics
http://sites.utexas.edu/pharmacotherapy-rounds/files/2015/09/kuriakose11-21-14.pdf
Pharmacokinetic Prediction of Levofloxacin Accumulation
MUSCULOSKELETAL
Preclinical safety evaluation of moxifloxacin
https://academic.oup.com/jac/article/43/suppl_2/91/2473568
Adverse Drug Reactions Related to the Use of Fluoroquinolones
Adverse Effects of Antimicrobials via Predictable or Idiosyncratic effects
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421593/pdf/zac4046.pdf
Effects of Difloxacin on the Metabolism of
https://www.sciencedirect.com/science/article/pii/S0272059083710341
Assessment of Musculoskeletal Toxicity 5 Years After
http://pediatrics.aappublications.org/content/pediatrics/134/1/e146.full.pdf
Fluoroquinolone Tendon Rupture Summary of Reports (FDA)
https://www.ncbi.nlm.nih.gov/pubmed/26393387
Cipro Induced Chondrotoxicity Tendinopathy
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.925.203&rep=rep1&type=pdf
FDA Warning and Study Highlight
https://jamanetwork.com/journals/jama/article-abstract/1737039?redirect=true
Levofloxacin-Induced Tendinopathy of the Hip
https://www.ncbi.nlm.nih.gov/pubmed/22535840
Fluoroquinolone Adverse Effects and Drug Interactions
http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full
https://www.ncbi.nlm.nih.gov/pubmed/11642691
Anxiogenic and proconvulsant effect of gatifloxacin in mice
https://www.ncbi.nlm.nih.gov/pubmed/18022617
Safety of fluoroquinolones update
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/pdf/JID13054.pdf
Pathogenesis of quinolone...
https://www.ncbi.nlm.nih.gov/pubmed/15633793
Synergistic Effect of Ofloxacin and Magnesium Deficiency on Joint
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC127237/pdf/0776.pdf
Comparative Evaluation of Ultrastructural
http://journals.sagepub.com/doi/pdf/10.1177/019262339602400507
Cipro study Toxicity
http://studyres.com/doc/7164464/chapter-3-fluoroquinolone-toxicity-to-tendons
Toxicological studies on pipemidic acid versus effect on diarthrodial joints
https://www.ncbi.nlm.nih.gov/pubmed/105148
Quinolone-Induced Arthropathy in Neonatal Foals
Quinolone arthropathy in immature rabbits treated with the fluoroquinolone, (1)
https://www.ncbi.nlm.nih.gov/pubmed/8811288
http://www.sciencedirect.com/science/article/pii/S0940299396800030?via%3Dihub
Investigation of fluoroquinolone-induced myalgia
http://onlinelibrary.wiley.com/doi/10.1002/art.10094/pdf
Fluoroquinolone-Mediated Inhibition of Cell Growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424257/pdf/pone.0042960.pdf
Comparison of plasma and tissue disposition of
https://www.ncbi.nlm.nih.gov/pubmed/25372241
Treatment of the Fluoroquinolone Associated Disability –
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632915/pdf/OMCL2017-8023935.pdf
https://www.hindawi.com/journals/omcl/2017/8023935/
Fluoroquinolones-Induced Tendinitis and Tendon
https://www.ncbi.nlm.nih.gov/pubmed/17580216
Fluoroquinolones May Increase Aortic
https://www.medpagetoday.com/cardiology/prevention/53950
Fluoroquinolone toxicity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981197/pdf/cp-2012-4-e87.pdf
Nanobiotics Effects of Fluoroquinolones in Mammalian Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf
http://www.jbc.org/content/290/36/22287.full.pdf
Ultrastructural changes induced by the des-F(7)-quinolone garenoxacin
https://www.ncbi.nlm.nih.gov/pubmed/12811465
https://link.springer.com/article/10.1007/s00204-003-0478-3
Ultrastructural Changes in Articular Cartilages of
http://journals.sagepub.com/doi/pdf/10.1177/030098589202900307
Toxicological Assessment of Trace b-Diketone Antibiotic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111491/pdf/pone.0102731.pdf
Toxic Effects of Quinolone Antibacterial Agents on the Musculoskeletal System
https://www.ncbi.nlm.nih.gov/pubmed/9437810
Third and Fourth Generation Fluoroquinolone
https://www.ncbi.nlm.nih.gov/pubmed/24410307
The perils of prescribing fluoroquinolones
https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf
The effects of levofloxacin on rabbit anterior cruciate ligament cells in vitro
Toxic Effects of Levofloxacin on Rat Annulus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237079/pdf/medscimonit-20-2205.pdf
Synergistic effects of dexamethasone and quinolones on human-derived
https://www.ncbi.nlm.nih.gov/pubmed/20034766
http://www.ijaaonline.com/article/S0924-8579(09)00483-X/fulltext
Safety issues and drug—drug
https://www.ncbi.nlm.nih.gov/pubmed/25423877
Risk of Aortic Dissection and Aortic Aneurysm
https://www.ncbi.nlm.nih.gov/pubmed/26436523
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2451282
Quinolone-induced arthropathy an update focusing on new mechanistic and clinical
https://www.ncbi.nlm.nih.gov/pubmed/18835137
https://www.sciencedirect.com/science/article/pii/S0924857908003531
Quinolone associated tendonitis COPD
https://link.springer.com/article/10.1007/BF03173892
Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells
https://pdfs.semanticscholar.org/0eef/309042885bf1fe3befcf0b5ccb7540840342.pdf
Further analysis of the risk of adverse birth outcome after maternal use of fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/16144758
Fluoroquinolone-Induced Tendinopathy
https://pdfs.semanticscholar.org/b8ff/5ef2016ac6548d0976a2189a744666a06edf.pdf
Effects of Ofloxacin on Integrin Expression
https://www.ncbi.nlm.nih.gov/pubmed/20650069
Pharmacological agents and impairment of fracture healing -What is the evidence
https://pdfs.semanticscholar.org/7009/158be1562b272f07cc3d7f79fb78dc724c02.pdf
Pathogenesis of Tendon Rupture Secondary to Fluoroquinoloone Therapy
https://www.ncbi.nlm.nih.gov/pubmed/17538473
Oral toxicity of pefloxacin, norfloxacin, ofloxacin and ciprofloxacin
https://www.ncbi.nlm.nih.gov/pubmed/21628961
Oral Fluoroquinolones and the Risk
https://jamanetwork.com/journals/jama/fullarticle/1148331
Oral Fluoroquinolone and Aortic Dissection and Aortic Aneurysm Risk
Ofloxacin induces oxidative damage to joint chondrocytes of juvenile rabbits
https://www.ncbi.nlm.nih.gov/pubmed/19818344
Ofloxacin induces apoptosis in microencapsulated juvenile rabbit
https://www.ncbi.nlm.nih.gov/pubmed/17961619
Ocular toxicity of fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/17760640
Non-antibiotic-effects-of-fluoroquinolones-in-mammalian-cells
http://www.jbc.org/content/290/36/22287.full.pdf
Levofloxacin-induced Achilles tendon rupture in a patient with systemic
https://www.ncbi.nlm.nih.gov/pubmed/17029067
https://link.springer.com/article/10.1007/s10165-005-0393-y
Levofloxacin-induced Achilles tendinitis and tendon rupture
http://www.europeangeriaticmedicine.com/article/S1878-7649(12)00116-7/abstract
http://www.sciencedirect.com/science/article/pii/S1878764912001167
Musculoskeletal Complications of Fluoroquinolones
https://www.ncbi.nlm.nih.gov/pubmed/21333952
Levofloxacin-Induced Tendon Rupture A Case Report and Review of the Literature
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.878.6133&rep=rep1&type=pdf
Fluoroquinolones influence the intracellular calcium handling in individuals
http://onlinelibrary.wiley.com/doi/10.1002/mus.22021/full
In vitro study of cytotoxicity of quinolones on rabbit tenocytes
https://link.springer.com/article/10.1023/A:1007435025616
In Vitro Evidence for Effects of Magnesium Supplementation
https://www.ncbi.nlm.nih.gov/pubmed/11280370
Fluoroquinolone Induced Tendinopathy
https://www.jstage.jst.go.jp/article/tjem/226/4/226_4_251/_pdf
Role of the new Fluoroquinolones in pediatric practice
Fluoroquinolones cause changes in extracellular matrix, signaling proteins
https://www.ncbi.nlm.nih.gov/pubmed/15890441
Fluoroquinolones and collagen associated severe adverse events a longitudinal cohort study
http://bmjopen.bmj.com/content/bmjopen/5/11/e010077.full.pdf
Effects of sparfloxacin on CNS functions
https://www.ncbi.nlm.nih.gov/pubmed/16701999
Effects of Ofloxacin in Integrin Expression
https://www.ncbi.nlm.nih.gov/pubmed/20650069
Effects of fluoroquinolones and glucocorticoids on cultivated tendon cells in vitro
https://www.ncbi.nlm.nih.gov/pubmed/20650258
Effects of fuoroquinolones and magnesium defciency
https://link.springer.com/article/10.1007/s002040050521
Effect of various concentrations of antibiotics on osteogenic cell viability and activity
https://www.ncbi.nlm.nih.gov/pubmed/21567453
Influence on Mitochondria and Cytotoxicity of Different Antibiotics https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797653/pdf/0729-05.pdf
In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon
http://jpet.aspetjournals.org/content/jpet/308/1/394.full.pdf
Gene expression profiles in the articular cartilage of juvenile rats receiving the
https://www.ncbi.nlm.nih.gov/pubmed/18572299
Effect of levofloxacin on glycosaminoglycan and DNA synthesis of cultured rabbit
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.845.2627&rep=rep1&type=pdf
Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells
https://www.ncbi.nlm.nih.gov/pubmed/23813946
Positive Association Between Fluoroquinolone Exposure and Tendon Disorders: A Nationwide Population-Based Cohort Study in Taiwan
https://pubmed.ncbi.nlm.nih.gov/35387340/
Quinolones-Induced Musculoskeletal, Neurological, and Psychiatric ADRs: A Pharmacovigilance Study Based on Data From the Italian Spontaneous Reporting System
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