Scientific Studies

ACCUMULATION

Pharmacokinetic prediction of levofloxacin accumulation in tissue and its association to tendinopathy

https://www.researchgate.net/publication/261759355_Pharmacokinetic_prediction_of_levofloxacin_accumulation_in_tissue_and_its_association_to_tendinopathy

Concurrent determination of four fluoroquinolones in catfish, shrimp, and salmon by liquid chromatography with fluorescence detection

https://www.ncbi.nlm.nih.gov/pubmed/12477191

Screening of Antibiotic Residues in Poultry Liver, Kidney and Muscle in Khartoum State, Sudan

https://pdfs.semanticscholar.org/5640/556fcccf7260990ad15703928eab8db73058.pdf

 

WHAT IS ADDUCTION/SPECTOGRAPHY/VARIOUS EXAMPLES OF CHEMICAL DNA ADDUCTION/ LIQUID CHROMATOGRAPHY/MOLECULAR DETAILS OF QUINOLONE DNA INTERACTIONS

DNA Adduct Profiles

https://www.sciencedirect.com/science/article/pii/S1367593107000701

https://www.ncbi.nlm.nih.gov/pubmed/17574899

DNA Adducts – mutations – cancer

https://www.ncbi.nlm.nih.gov/pubmed/11162720

DNA Adducts Endogenous

http://journals.sagepub.com/doi/pdf/10.1177/019262330002800308

DNA Adduction in Context: Native Metabolic Activation of Affoobdorne Procarcinogen and Adducted Oligonucleotide Sequencing Monitored by LC-MS/MS

https://repository.library.northeastern.edu/files/neu:728/fulltext.pdf

DNA Adducts and Their Consequences

https://www-legacy.dge.carnegiescience.edu/SCOPE/SCOPE_52/SCOPE_52_2.01_Beland_29-56.pdf

DNA Adducts: Endogenous and Induced

https://www.ncbi.nlm.nih.gov/pubmed/10862557

Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection

https://www.ncbi.nlm.nih.gov/pubmed/16272169

https://academic.oup.com/carcin/article/27/2/178/2476104

On the Effect of Covalently Appended Quinolones on Termini of DNA Duplexes

http://pubs.acs.org/doi/abs/10.1021/ja0125117

Learn more about DNA Adduct

https://www.sciencedirect.com/topics/neuroscience/dna-adduct

DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes

https://www.ncbi.nlm.nih.gov/pubmed/19122895

Acyl Glucuronidation of fluoroquinolone antibiotics by the udpglucuronosyltransferase 1A subfamily in human liver microsomes

https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf

Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action?

https://www.ncbi.nlm.nih.gov/pubmed/25515946

Tandem mass spectrometric study of ciprofloxacin–poly(ethylene glycol) conjugate in the presence of alkali metal ions

https://www.sciencedirect.com/science/article/pii/S1387380608002108

Molecular Docking Experiments of 4-Oxotheino [3,2-c] quinoline-2-carboxylates with DNA and their Potential Anticancer Property

https://www.researchgate.net/publication/324834725_Molecular_Docking_Experiments_of_4-Oxotheino_32-c_quinoline-2-carboxylates_with_DNA_and_their_Potential_Anticancer_Property

Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells

https://www.ncbi.nlm.nih.gov/pubmed/23813946

A reply: “Do quinolones bind to DNA” – Yes

https://www.sciencedirect.com/science/article/pii/0006295289905054

Spectroscopic Studies on the Binding of Some Fluoroquinolones with DNA

https://www.ncbi.nlm.nih.gov/pubmed/23434558

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg2+ to the second metal binding site

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720527/pdf/nihms749655.pdf

Characterization of ciprofloxacin binding to the linear single- and double-stranded DNA

https://www.ncbi.nlm.nih.gov/pubmed/12890558

Mechanism of Quinolone Inhibition of DNA Gyrase

http://www.jbc.org/content/264/5/2973.full.pdf

Interaction between ciprofloxacin and DNA mediated by Mgt + -ions

https://www.ncbi.nlm.nih.gov/pubmed/21820989

Influence of copper(II) and magnesium(II) ions on the ciprofloxacin binding to DNA

http://www.bf.uni-lj.si/fileadmin/groups/2747/Zaposleni/Natasa_Poklar_Ulrih/2003-NPU-JIB.pdf

Interaction between ciprofloxacin and DNA mediated by Mg2_-ions

https://www.sciencedirect.com/science/article/pii/S0020169302009337

Interaction study of ciprofloxacin with human telomeric DNA by spectroscopy and molecular docking

https://www.ncbi.nlm.nih.gov/pubmed/23434548

Structural Insight into a Quinolone-Topoisomerase II-DNA Complex

http://www.jbc.org/content/274/24/17226.full.pdf

The complexes of metal ions with Fluoroquinolones

https://link.springer.com/article/10.1134/S1070328409020018

https://www.researchgate.net/publication/226755953_The_complexes_of_metal_ions_with_fluoroquinolones

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

http://www.jbc.org/content/270/37/21429.full.pdf

DNA adduct profiles: chemical approaches to addressing the biological impact of DNA damage from small molecules

https://www.ncbi.nlm.nih.gov/pubmed/17574899

https://www.sciencedirect.com/science/article/abs/pii/S1367593107000701?via%3Dihub

DNA adduction in context: native metabolic activation of a foodborne procarcinogen and adducted oligonucleotide sequencing monitored by LC-MS/MS

https://www.researchgate.net/publication/45062923_DNA_adduction_in_context_native_metabolic_activation_of_a_foodborne_procarcinogen_and_adducted_oligonucleotide_sequencing_monitored_by_LC-MSMS

DNA Adducts – mutations – cancer

http://aether.cmi.ua.ac.be/artikels/MB_30229.pdf

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855444/pdf/pone.0010186.pdf

Antibacterial and Anticancer Drugs Interaction with DNA

https://pdfs.semanticscholar.org/9298/604f37c935936a3e8384829c748af820944a.pdf

Effect of metal ions on some pharmacologically relevant interactions involving fl uoroquinolone antibiotics https://www.researchgate.net/profile/Neelam_Seedher/publication/50591479_Effect_of_metal_ions_on_some_pharmacologically_relevant_interactions_involving_fl_uoroquinolone_antibiotics/links/57f4ce4808ae8da3ce54ea48/Effect-of-metal-ions-on-some-pharmacologically-relevant-interactions-involving-fl-uoroquinolone-antibiotics.pdf

DNA Adducts and Their Consequences

https://dge.carnegiescience.edu/SCOPE/SCOPE_52/SCOPE_52_2.01_Beland_29-56.pdf

On the Effect of Covalently Appended Quinolones on Termini of DNA Duplexes

https://www.ncbi.nlm.nih.gov/pubmed/11960452

Synthesis, characterization and DNA binding of magnesium–ciprofloxacin (cfH) complex [Mg(cfl 2]. 2.5H2O

http://www.bf.uni-lj.si/fileadmin/groups/2747/Zaposleni/Natasa_Poklar_Ulrih/2006-NPU-JIB.pdf

DNA Adducts: Endogenous and Induced

https://www.researchgate.net/profile/Andrew_Povey/publication/12455356_DNA_Adducts_Endogenous_and_Induced/links/004635231c89a85c60000000.pdf

Drug bioactivation and protein adduct formation in the pathogenesis of

drug-induced toxicity https://www.researchgate.net/profile/Dominic_Williams2/publication/46287694_Drug_bioactivation_and_protein_adduct_formation_in_the_pathogenesis_of_drug-induced_toxicity/links/59e07a4ca6fdcca98431cbef/Drug-bioactivation-and-protein-adduct-formation-in-the-pathogenesis-of-drug-induced-toxicity.pdf

Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection

https://www.ncbi.nlm.nih.gov/pubmed/16272169

Molecular details of quinolone–DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192833/pdf/gki795.pdf

Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode

http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f#!divAbstract

A “Double-Edged” Scaffold Antitumor Power within the Antibacterial Quinolone

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997924/pdf/CMC-23-520.pdf

A theoretical-experimental study on the structure and activity of certain quinolones and the interaction of their Cu(II)-Complexes on a DNA model https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365236/pdf/MBD-07-301.pdf

Base-displaced intercalation of the 2-amino-3-methylimidazo[4,5-f]quinolone N2-dG adduct in the NarI DNA recognition sequence  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950664/pdf/gkt1109.pdf

Chemo-Targeting_DNA_topoisomerase_II in cancer Chemotherapy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748742/pdf/nihms120024.pdf

Copper(II)–fluoroquinolone complexes with anti-Trypanosoma cruzi activity and DNA binding ability

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746275/pdf/BCA2016-5027404.pdf

Crystal structure, characterisation and biological activity of copper(II)-ciprofloxacin inoic compound https://www.researchgate.net/publication/279899521_Crystal_structure_characterisation_and_biological_activity_of_copperII-ciprofloxacin_ionic_compound

DNA interaction, cytotoxicity, antibacterial and antituberculosis activity of oxovanadium(IV) complexes derived from fluoroquinolones and 4-hydroxy-5-((4-ydroxyphenyl)diazenyl)thiazole-2(3H)-thione

http://pubs.rsc.org/-/content/articlelanding/2015/ra/c5ra01222h/unauth#!divAbstract

DNA interaction and cytotoxic activities of square planar platinum(II) complexes with N, S-donor ligands.

https://www.ncbi.nlm.nih.gov/pubmed/24632234

https://www.sciencedirect.com/science/article/pii/S1386142514002406?via%3Dihub

Development of a Monoclonal Antibody-Based Broad-Specificity ELISA for fluoroquinolone Antibiotics in Foods and Molecular Modeling Studies of Cross-Reactive Compounds

https://www.ncbi.nlm.nih.gov/pubmed/17511422

Norfloxacin La(III)-based complex Synthesis characterization and DNA binding studies

https://www.researchgate.net/publication/279180088_Norfloxacin_LaIII-based_complex_Synthesis_characterization_and_DNA_binding_studies

https://www.tandfonline.com/doi/abs/10.1080/00958972.2015.1065320?journalCode=gcoo20

NMR investigation of pefloxacin/cation/DNA interactions. Mg 2 + and Ca 2 + Binding

https://www.sciencedirect.com/science/article/pii/S037851739700389X

Molecular Analysis of Yeast and Human Type II Topoisomerases

http://www.jbc.org/content/274/40/28246.full.pdf

Mg2 +-Mediated Binding of 6-Substituted Quinolones to DNA: Relevance to Biological Activity

https://www.ncbi.nlm.nih.gov/pubmed/9801827

Quinolones: Action and Resistance Updated

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182077/pdf/CTMC-9-981.pdf

Synthesis, Crystal Structure, Stacking Effect and Antibacterial Studies of a Novel Quaternary Copper (II) Complex with Quinolone

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.361.8571&rep=rep1&type=pdf

The Structure of DNA-Bound Human Topoisomerase II Alpha: Gonformational Mechanisms for Goordinating Inter-Subunit Interactions with DNA Cleavage

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584591/pdf/nihms397579.pdf

The RuvAB Branch Migration Complex Can Displace Topoisomerase IV_Quinolone_DNA Ternary Complexes*

http://www.jbc.org/content/278/48/48485.full.pdf

In Vitro Evaluation of Zn–Norfloxacin Complex as a Potent Cytotoxic and Antibacterial Agent, Proposed Model for DNA Binding

https://www.ncbi.nlm.nih.gov/pubmed/23636652

Pharmacokinetic interactions related to the chemical structures of fluoroquinolones

https://watermark.silverchair.com/37-suppl_A-41.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAlEwggJNBgkqhkiG9w0BBwagggI-MIICOgIBADCCAjMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMz4phsGBESJGRQnYkAgEQgIICBF_CK_X1pdxu3y7OiHObggp6wolxvpoKTeB6bYaoV2ETlnaeNW6Hs1e0yHqHfco06P2DL0-5ApEKH-KtDFKRjw05CcpIOxotSUVlRcJoYQH-GFnLys6bpbaJRLvENMfaOYFSXRSxmF4EDcFeA4C2MJxPj8ZqA_Qyb4e3Lq5V7_lxmywAI3sKhNqwO_fwWH-NZL7tb07W0xJHGkmatBjqhoX367NoFC9wFNrXRrJH2cuzsmhayQ3N6JWNCAtHKt5a_VHLg_Li9hlqZrxeV3y4h7JHg0uRQu6OtquL6Q2BUYRWxjUYhJvWZcRQJlHbtUUpVd7Z47J-qExQKqpqvi0j32hszmW2r1JzAz_8DIqgXLkWhQSLWZWkkDeKGTUSHj4_vKHurRTymWpdyl-v-NXUUYSoRWS8Xx40qGun08Eg3YVHZubW6BD_WCRCV4Of7wWkiU71wXinEzP6FK4xJE9N2ytd4_-LAGeKq6WL1dpomazOcxnSnNjIcrnoCNYGBtPoSQ_WigaApSaFq6kQzdEaKcPypPl2P151iKnfIGoNoAycDE05VMfc11LanmnHpxtSFdFUMdPnRdjyaN9wbTkLjBjGUvw1viDrlsi8nG5LdCXG6pzejLLFUNm6GhwrtBv46_wsY1ajTcQsHFDpiJkCRvP0ZGArfTG8gcUKPvMNSdUWapUD4g

Type II Topoisomerases as Targets for Quinolone Antibacterials: Turning Dr. Jekyll into Mr. Hyde

https://www.ncbi.nlm.nih.gov/pubmed/11254893

 

ASSAY TECHNIQUES

A one-step chemiluminescence immunoassay for 20 fluoroquinolone residues in fish and shrimp based on a single chain Fv–alkaline phosphatase fusion protein

http://pubs.rsc.org/en/Content/ArticleLanding/2015/AY/c5ay01410g#!divAbstract

https://www.researchgate.net/publication/280974405_A_one-step_chemiluminescence_immunoassay_for_20_fluoroquinolone_residues_in_fish_and_shrimp_based_on_a_single_chain_Fv-alkaline_phosphatase_fusion_protein

A simple and rapid high performance liquid chromatography method to determine levofloxacin in human plasma and its use in a bioequivalence study

http://www.ddtjournal.com/action/downloaddoc.php?docid=63

Acyl glucuronidation of fluoroquinolone antibiotics by the udpglucuronosyltransferase 1A subfamily in human liver microsomes

https://pdfs.semanticscholar.org/78ee/bbe021406be4a6a23af1de4b16323f765fb5.pdf

Analytical profile of the fluoroquinolone antibacterials. I. Ofloxacin

https://www.ajol.info/index.php/ajb/article/view/58495/46839

Chemiluminescence competitive indirect enzyme immunoassay for 20 fluoroquinolone residues in fish and shrimp based on a single-chain variable fragment

https://www.ncbi.nlm.nih.gov/pubmed/23842902

https://link.springer.com/article/10.1007%2Fs00216-013-7174-9

 

BACTERIAL RESISTANCE

Topoisomerase mutations and efflux are associated with fluoroquinolone resistance in Enterococcus faecalis http://www.microbiologyresearch.org/docserver/fulltext/jmm/55/10/1395.pdf?expires=1515012480&id=id&accname=guest&checksum=388D1776DAD602047533F757E7463CE8

 

CARCINOGENICITY

Quinolone antibacterials: a new class of photochemical carcinogens

https://www.ncbi.nlm.nih.gov/pubmed/9085565

http://www.sciencedirect.com/science/article/pii/S1011134496074258?via%3Dihub

Study for genotoxicity and carcinogenicity of quinolone antimicrobials in mammals

https://www.researchgate.net/publication/247097248_Study_for_genotoxicity_and_carcinogenicity_of_quinolone_antimicrobials_in_mammals

https://docslide.com.br/documents/study-for-genotoxicity-and-carcinogenicity-of-quinolone-antimicrobials-in-mammals.html

Photochemical mutagenicity of phototoxic and photochemically carcinogenic fluoroquinolones in comparison with the photostable moxifloxacin.

https://www.ncbi.nlm.nih.gov/pubmed/11131036

https://link.springer.com/article/10.1007%2Fs002040000162?LI=true

 

CARDIAC

Preclinical safety evaluation of moxifloxacin, a novel fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/10382881

Cardiovascular and metabolic safety profiles of the fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/21958023

Acute and subacute (20-d) oral dose toxicity study of modified fluoroquinolone compound 6C in BALB/c mice

https://www.tandfonline.com/doi/abs/10.3109/15569543.2015.1076483

http://www.tandfonline.com/doi/abs/10.3109/15569543.2015.1076483?src=recsys&journalCode=itxr20

https://www.researchgate.net/publication/281174378_Acute_and_subacute_20-d_oral_dose_toxicity_study_of_modified_fluoroquinolone_compound_6C_in_BALBc_mice?el=1_x_2&enrichId=rgreq-e46136fb-bde7-4077-b86b-ca35779952d6&enrichSource=Y292ZXJQYWdlOzI4MTE3NDM3ODtBUzozNDI3MDQ3MDI2NzI4OTZAMTQ1ODcxODU3NjQ5OQ%3D%3D

Adverse Drug Reactions Related to the Use of Fluoroquinolone Antimicrobials

https://www.researchgate.net/profile/Roberto_Leone/publication/10945635_Adverse_drug_reactions_related_to_the_use_of_fluoroquinolone_antimicrobials_an_analysis_of_spontaneous_reports_and_fluoroquinolone_consumption_data_from_three_italian_regions/links/0912f50e538574cc25000000/Adverse-drug-reactions-related-to-the-use-of-fluoroquinolone-antimicrobials-an-analysis-of-spontaneous-reports-and-fluoroquinolone-consumption-data-from-three-italian-regions.pdf

https://www.ncbi.nlm.nih.gov/pubmed/12534327

Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092995/pdf/hir-17-58.pdf

https://www.ncbi.nlm.nih.gov/pubmed/21818458

Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy

https://www.ncbi.nlm.nih.gov/pubmed/19387967

https://www.ncbi.nlm.nih.gov/pubmed/19387967

Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study

http://bmjopen.bmj.com/content/bmjopen/5/11/e010077.full.pdf

https://bmjopen.bmj.com/content/5/11/e010077

Quinolones: Cardioprocective or Cartiotoxic?

https://www.ncbi.nlm.nih.gov/pubmed/14675020

http://onlinelibrary.wiley.com/doi/10.1111/j.1540-8159.2003.00367.x/abstract

https://www.ncbi.nlm.nih.gov/pubmed/14675020

Relationship of cellular topoisomerase II a inhibition to cytotoxicity and published genotoxicity of fluoroquinolone antibiotics in V79 cells https://www.sciencedirect.com/science/article/pii/S0009279713000057

https://www.ncbi.nlm.nih.gov/pubmed/23340199

Synthesis, characterization, antimicrobial, SODmimic and DNA interaction behavior of copper(II) complexes with pefloxacin and phenanthroline derivatives

http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0149198&type=printable

https://onlinelibrary.wiley.com/doi/abs/10.1002/aoc.1766

Effect of Macrolide and Fluoroquinolone Antibacterials on the Risk of Ventricular Arrhythmia and Cardiac Arrest

https://www.researchgate.net/profile/Hernan_Polo_Friz/publication/24033863_Effect_of_Macrolide_and_Fluoroquinolone_Antibacterials_on_the_Risk_of_Ventricular_Arrhythmia_and_Cardiac_Arrest/links/54f6e7f50cf27d8ed71ff251.pdf

https://www.ncbi.nlm.nih.gov/pubmed/19236122

Quinolone induced QT interval prolongation: a not-so-unexpected class effect

https://www.ncbi.nlm.nih.gov/pubmed/10797074

Oral Fluoroquinolone and Aortic Dissection and Aortic Aneurysm Risk

https://www.ncbi.nlm.nih.gov/pubmed/26436523

http://www.acc.org/latest-in-cardiology/journal-scans/2015/10/06/15/33/risk-of-aortic-dissection-and-aortic-aneurysm-in-patients-taking-oral-fluoroquinolone

Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/26436523

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2451282

Risks of Cardiac Arrhythmia and Mortality Among Patients Using New-Generation

Macrolides, Fluoroquinolones, and β-Lactam/ β-Lactamase Inhibitors: A Taiwanese Nationwide Study

https://www.ncbi.nlm.nih.gov/pubmed/25409476

Safety issues and drug—drug interactions with commonly used quinolones

https://www.ncbi.nlm.nih.gov/pubmed/25423877

https://www.researchgate.net/publication/268816291_Safety_issues_and_drug-drug_interactions_with_commonly_used_quinolones

Torsades de pointes associated with fluoroquinolones: Importance of concomitant risk factors

https://www.ncbi.nlm.nih.gov/pubmed/15001976

http://onlinelibrary.wiley.com/doi/10.1016/j.clpt.2003.11.376/abstract;jsessionid=489433439AB92E1E398D07445C01B2BD.f04t02

The perils of prescribing fluoroquinolones

https://www.mdedge.com/familymedicine/article/65086/perils-prescribing-fluoroquinolones

http://go.galegroup.com/ps/anonymous?p=AONE&sw=w&issn=00943509&v=2.1&it=r&id=GALE%7CA326852127&sid=googleScholar&linkaccess=fulltext&authCount=1&isAnonymousEntry=true

https://ocimc.files.wordpress.com/2013/04/fluoroquinolones.pdf

The Safety Profile of the Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/10945507

The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel

https://www.ncbi.nlm.nih.gov/pubmed/23711922

http://www.sciencedirect.com/science/article/pii/S0960894X13005647?via%3Dihub

Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

https://www.ncbi.nlm.nih.gov/pubmed/24410307

Toxicological Assessment of Trace b-Diketone Antibiotic Mixtures on Zebrafish (Danio rerio) by Proteomic Analysis

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102731

https://www.ncbi.nlm.nih.gov/pubmed/25062015

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111491/pdf/pone.0102731.pdf

Mechanism of hERG Kþ channel blockade by the fluoroquinolone antibiotic moxifloxacin

https://www.ncbi.nlm.nih.gov/pubmed/16474415

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1760709/pdf/147-0706678a.pdf

Fluoroquinolones May Increase Aortic Aneurysm Risk

https://www.medpagetoday.com/cardiology/prevention/53950

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect – comprehensive overview of clinical trials

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785617/pdf/40360_2016_Article_53.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26960809

Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419912/pdf/bph0166-1694.pdf

https://www.ncbi.nlm.nih.gov/pubmed/22289150

The effect of levofloxacin and moxifloxacin on cardiovascular functions of rats with  streptozotocin induced diabetes

https://www.ncbi.nlm.nih.gov/pubmed/22621918

Fluoroquinolone induces human aortic fibroblast-mediated extracellular matrix dysregulation

http://www.onlinecjc.ca/article/S0828-282X(17)30468-3/pdf

https://www.onlinecjc.ca/article/S0828-282X(17)30468-3/abstract

Safety of fluoroquinolones: An update

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/pdf/JID13054.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094848/

The Quinolones, Ch 16, Prospects

https://www.sciencedirect.com/science/article/pii/B9780120595174500179

Rates of Torsades de Pointes Associated with Ciprofloxacin, Ofloxacin, Levofloxacin, Gatifloxacin, and Moxifloxacin

https://www.ncbi.nlm.nih.gov/pubmed/11765299

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.20.1468.34482/abstract

Fluoroquinolone Adverse Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691

Sparfloxacin, a Fluoroquinolone Antibiotic, Slows Inactivation of L-Type a2D C Current in Neonatal Rat Ventricular Myocytes

http://www.cell.com/biophysj/pdf/S0006-3495(14)01834-7.pdf

CARTILAGE

 

Clinical toxicological aspects of fluoroquinolones

http://fqvictims.org/fqvictims/News/Clinical%20Toxicological%20Aspects%20of%20FQs/Clinical%20Toxicological%20Aspects%20of%20Fluroquinolones.pdf

Comparative Evaluation of Ultrastructural Changes in Articular Cartilage of Ofioxacin-Treated and Magnesium-Deficient Immature Rats*

https://www.ncbi.nlm.nih.gov/pubmed/8923679

Confirmation of fluoroquinolone residues in salmon and shrimp tissue by LC/MS: Evaluation of single quadrupole and ion trap instruments

https://www.researchgate.net/publication/237526315_Confirmation_of_fluoroquinolone_residues_in_salmon_and_shrimp_tissue_by_LCMS_Evaluation_of_single_quadrupole_and_ion_trap_instruments

 

CHEMISTRY

 

Investigating the fluoroquinolone-topoisomerase interaction by use of novel fluoroquinolone and quinazoline analogs

http://ir.uiowa.edu/cgi/viewcontent.cgi?article=2403&context=etd

https://ir.uiowa.edu/etd/1018/

The Complexes of Metal Ions with Fluoroquinolones

https://link.springer.com/article/10.1134/S1070328409020018

https://www.researchgate.net/publication/226755953_The_complexes_of_metal_ions_with_fluoroquinolones?el=1_x_2&enrichId=rgreq-3b3141eb-c68c-447f-8565-30c9ccb9ac66&enrichSource=Y292ZXJQYWdlOzIyNjc1NTk1MztBUzozMzk1Mzc2OTI3NzQ0MDJAMTQ1Nzk2MzUwMjQ5MQ%3D%3D

Synthesis, characterization, antimicrobial and cytotoxicity studies of some transition metal complexes with gemifloxacin

https://link.springer.com/article/10.1007/s00706-015-1507-7

https://www.researchgate.net/publication/282539276_Synthesis_characterization_antimicrobial_and_cytotoxicity_studies_of_some_transition_metal_complexes_with_gemifloxacin

http://www.academia.edu/27979159/Synthesis_characterization_antimicrobial_and_cytotoxicity_studies_of_some_transition_metal_complexes_with_gemifloxacin

A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods

https://link.springer.com/article/10.1007/s00204-009-0509-9

https://www.ncbi.nlm.nih.gov/pubmed/20049419

Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode

https://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt04011f

https://www.researchgate.net/publication/285630343_CopperI_complexes_with_phosphine_derived_from_sparfloxacin_Part_II_a_first_insight_into_the_cytotoxic_action_mode

 

CHONDROCYTES

 

Comparative Evaluation of Ultrastructural Changes in Articular Cartilage of Ofioxacin-Treated and Magnesium-Deficient Immature Rats*

https://www.ncbi.nlm.nih.gov/pubmed/8923679

 

CLINICAL STUDY

 

Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro

http://www.nmcth.edu/images/gallery/Editorial/xRZVmps_ambulkar.pdf

Fluoroquinolones and Musculoskeletal Toxicity in Pediatrics: Is The Fear Real?

http://sites.utexas.edu/pharmacotherapy-rounds/files/2015/09/kuriakose11-21-14.pdf

Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092995/pdf/hir-17-58.pdf

https://www.ncbi.nlm.nih.gov/pubmed/21818458

Diagnostic failure of ciprofloxacin-induced spontaneous bilateral Achilles tendon rapture: case-reported and medical legal consideration

https://www.ncbi.nlm.nih.gov/pubmed/21658328

Emergency Department Visits for Antibiotic- Associated Adverse Events

https://www.ncbi.nlm.nih.gov/pubmed/18694344

https://pdfs.semanticscholar.org/1899/bafdc7edb82d8a70c042bf015db299a2a5b3.pdf

Severe hypoglycemia associated with levofloxacin in Type 2 diabetic patients receiving polytherapy: two case reports

https://www.ncbi.nlm.nih.gov/pubmed/22456302

Ciprofloxacin-associated choreoathetosis in a haemodialysis patient

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645130/pdf/bcr-2013-009293.pdf.

https://www.ncbi.nlm.nih.gov/pubmed/23605987

Unnecessary use of fluoroquinolone antibiotics in hospitalized patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145580/pdf/1471-2334-11-187.pdf

https://www.ncbi.nlm.nih.gov/pubmed/21729289

US-Based Emergency Department Visits for Fluoroquinolone-Associated Hypersensitivity Reactions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635672/pdf/nihms732049.pdf

https://www.ncbi.nlm.nih.gov/pubmed/23963962

Crystal-induced acute kidney injury due to ciprofloxacin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316583/pdf/JNP-4-29.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316583/

Characterization of N-Glucuronidation of 4-(5-Pyridin-4-yl-1H– [1,2,4]triazol-3-yl)pyridine-2-carbonitrile (FYX-051): A New Xanthine Oxidoreductase Inhibitor

http://dmd.aspetjournals.org/content/dmd/35/12/2143.full.pdf

https://www.ncbi.nlm.nih.gov/pubmed/17761779

The Risk of Hepatotoxicity with Fluoroquinolones: A National Case-Control Safety Study

https://pdfs.semanticscholar.org/d8b9/369765128c9e72b8253900ac18953b469ead.pdf?_ga=2.31586366.1053620723.1561154198-51003240.1552665781

https://www.semanticscholar.org/paper/The-Risk-of-Hepatotoxicity-with-Fluoroquinolones-%3A-Morrill-Caffrey/d8b9369765128c9e72b8253900ac18953b469ead

 

CNS PNS ANS Neural

 

Preclinical safety evaluation of moxiftoxacin, a novel ftuoroquinolone

https://www.ncbi.nlm.nih.gov/pubmed/10382881

 

COLLAGEN MUTATION AND HIF GEGRADATION

 

Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571980/pdf/zbc22287.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26205818

 

CORNEAL CYTOTOXICITY

 

Concentrations of the des-F(6)-quinolone garenoxacin in plasma and joint cartilage of immature rats

https://www.ncbi.nlm.nih.gov/pubmed/14661070

 

CYTOTOXITY

 

Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro

http://www.nmcth.edu/images/gallery/Editorial/xRZVmps_ambulkar.pdf

https://www.ncbi.nlm.nih.gov/pubmed/20334059

4-Quinolone Drugs Affect Cell Cycle Progression and Function of Human Lymphocytes In Vitro

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/pdf/aac00096-0128.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC174830/

A comparative analysis of chromosomal aberrations in cultured human lymphocytes due to fluoroquinolone drugs at different expression periods

https://www.researchgate.net/publication/40848285_A_comparative_analysis_of_chromosomal_aberrations_in_cultured_human_lymphocytes_due_to_fluoroquinolone_drugs_at_different_expression_periods

https://www.ncbi.nlm.nih.gov/pubmed/20049419

Alteration of the Endocytotic Pathway by Photosensitization with Fluoroquinolones

http://onlinelibrary.wiley.com/doi/10.1562/0031-8655(2000)0720458AOTEPB2.0.CO2/full

https://www.ncbi.nlm.nih.gov/pubmed/11045714

Effects of Difloxacin on the Metabolism of Glycosaminoglycans and Collagen in Organ Cultures of Articular Cartilage

https://www.sciencedirect.com/science/article/pii/S0272059083710341

Calcium Signals Are Affected by Ciprofloxacin as a Consequence of Reduction of Mitochondrial DNA Content in Jurkat Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/pdf/1543-05.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472211/

Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action?

https://www.ncbi.nlm.nih.gov/pubmed/25515946

Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test

https://hal.archives-ouvertes.fr/hal-01191262/document

https://www.ncbi.nlm.nih.gov/pubmed/22047769

Assessment on the adverse effects of Aminoglycosides and Flouroquinolone on sperm parameters and male reproductive tissue: A systematic review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426151/pdf/ijrm-3-125.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26000002

Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/pdf/nihms-509241.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/

Biological activities of some Fluoroquinolones-metal complexes

https://www.researchgate.net/publication/270538458_Biological_activities_of_some_Fluoroquinolones-metal_complexes?el=1_x_2&enrichId=rgreq-52a57dae-60a0-4e3d-ae56-a986c57656e1&enrichSource=Y292ZXJQYWdlOzI3MDUzODQ1ODtBUzozNzA0MjIwNjQ0MDI0NDBAMTQ2NTMyNjkxMDg1Ng%3D%3D

https://www.ajol.info/index.php/ijmbr/article/view/91824

Butachlor induced dissipation of mitochondrial membrane potential, oxidative DNA damage and necrosis in human peripheral blood mononuclear cells

https://www.ncbi.nlm.nih.gov/pubmed/22884430

Copper(II) complexes with norfloxacin and neutral terpyridines: Cytotoxic, antibacterial, superoxide dismutase and DNA-interaction approach

https://www.sciencedirect.com/science/article/pii/S0277538712002112

Ciprofloxacin induced chondrotoxicity and tendinopathy http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.925.203&rep=rep1&type=pdf

https://pdfs.semanticscholar.org/31e5/c6845352b87aba23c60b714d7253cc2ab2de.pdf

Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms

https://www.ncbi.nlm.nih.gov/pubmed/25902267

Combined Use of In Vitro Phototoxic Assessments and Cassette Dosing Pharmacokinetic Study for Phototoxicity Characterization of Fluoroquinolones

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160149/pdf/12248_2011_Article_9292.pdf

https://www.ncbi.nlm.nih.gov/pubmed/21739333

Comparison of fluoroquinolones: cytotoxicity on human corneal epithelial cells

https://www.nature.com/articles/eye2009179.pdf

https://www.ncbi.nlm.nih.gov/pubmed/19648900

Cytotoxic effects of the quinolone levofloxacin on rabbit meniscus cells

https://www.ncbi.nlm.nih.gov/pubmed/23813946

Cytotoxicity of Quinolones toward Eukaryotic Cells

http://www.jbc.org/content/267/19/13150.full.pdf

https://www.ncbi.nlm.nih.gov/pubmed/1320012

 

DERMAL

 

Phototoxic Lesions Induced by Quinolone Antibacterial Agents in Auricular Skin and Retina of Albino Mice*

https://www.ncbi.nlm.nih.gov/pubmed/8052802

Effect of norfloxacin and moxifloxacin on melanin synthesis and antioxidant enzymes activity in normal human melanocytes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf

https://www.ncbi.nlm.nih.gov/pubmed/25433710

Adverse Drug Reactions Related to the Use of Fluoroquinolone Antimicrobials: An Analysis of Spontaneous Reports and Fluoroquinolone Consumption Data from Three Italian Regions

https://www.researchgate.net/profile/Roberto_Leone/publication/10945635_Adverse_drug_reactions_related_to_the_use_of_fluoroquinolone_antimicrobials_an_analysis_of_spontaneous_reports_and_fluoroquinolone_consumption_data_from_three_italian_regions/links/0912f50e538574cc25000000/Adverse-drug-reactions-related-to-the-use-of-fluoroquinolone-antimicrobials-an-analysis-of-spontaneous-reports-and-fluoroquinolone-consumption-data-from-three-italian-regions.pdf

https://www.ncbi.nlm.nih.gov/pubmed/12534327

Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones

https://www.ncbi.nlm.nih.gov/pubmed/11195848

Cutaneous leukocytoclastic vasculitis associated with levofloxacin therapy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892663/pdf/idr-2012-1-e11.pdf

https://www.ncbi.nlm.nih.gov/pubmed/24470918

Effect of norfloxacin and moxifloxacin on melanin synthesis and antioxidant enzymes activity in normal human melanocytes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315488/pdf/11010_2014_Article_2297.pdf

https://www.ncbi.nlm.nih.gov/pubmed/25433710

Evaluation of photodegradation, phototoxicity and photogenotoxicity of ofloxacin in ointments with sunscreens and in solutions

https://www.ncbi.nlm.nih.gov/pubmed/25728226

https://www.sciencedirect.com/science/article/pii/S101113441500041X

Formation of Antigenic Photoadducts on Langerhans Cells Photoallergy to Systemically Administered Quinolone in Mice

http://www.sciencedirect.com/science/article/pii/S0022202X15408115

https://www.ncbi.nlm.nih.gov/pubmed/10692119

Ofloxacin Induced Cutaneous Reactions in Children

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525525/pdf/jcdr-9-FD01.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525525/

Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669849/pdf/emss-66122.pdf

https://www.ncbi.nlm.nih.gov/pubmed/26134950

Cutaneous Vasculitis Associated with Fluoroquinolones

http://edoc.unibas.ch/25010/1/s15010-009-8437-4.pdf

https://www.ncbi.nlm.nih.gov/pubmed/19669086

Stimulation of Prostaglandin Production by Quinolone Phototoxicity in Balb/c 3T3 Mouse Fibroblast Cells in Vitro

https://www.ncbi.nlm.nih.gov/pubmed/9143485

https://www.sciencedirect.com/science/article/pii/S0272059096922824

Safety issues and drug—drug interactions with commonly used quinolones

https://www.ncbi.nlm.nih.gov/pubmed/25423877

https://www.researchgate.net/publication/268816291_Safety_issues_and_drug-drug_interactions_with_commonly_used_quinolones

The photomutagenicity of fluoroquinolones and other drugs

http://www.sciencedirect.com/science/article/pii/S0378427498002355

https://www.ncbi.nlm.nih.gov/pubmed/10022282

The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay)

https://fqresearch.org/pdf_files/The-photomutagenicity-of-fluoroquinolones-in-tests-for-gene-mutation-chromosomal-aberration-gene-conversion-and-DNA-breakage.pdf

https://academic.oup.com/mutage/article/11/5/497/1044656

Third and Fourth Generation Fluoroquinolone Antibacterials: A Systematic Review of Safety and Toxicity Profiles

https://www.ncbi.nlm.nih.gov/pubmed/24410307

Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation

https://www.sciencedirect.com/science/article/pii/S0887233316300285

https://www.ncbi.nlm.nih.gov/pubmed/26916084

Generalized Seizure and Toxic Epidermal Necrolysis Following Levofloxacin Exposure

https://www.researchgate.net/profile/Tabo_Sikaneta/publication/7910080_Generalized_Seizure_and_Toxic_Epidermal_Necrolysis_Following_Levofloxacin_Exposure/links/0c96053ac9095855c8000000/Generalized-Seizure-and-Toxic-Epidermal-Necrolysis-Following-Levofloxacin-Exposure.pdf

https://www.ncbi.nlm.nih.gov/pubmed/15827068

Fluoroquinolone Adverse Effects and Drug Interactions

http://onlinelibrary.wiley.com/doi/10.1592/phco.21.16.253S.33993/full

https://www.ncbi.nlm.nih.gov/pubmed/11642691